Skip to main content
SpringerLink
Log in

Renalase levels in children with solitary functioning kidney

  • Research Paper
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To measure serum and urine renalase levels in children with a single kidney, and to compare with a reference group.

Methods

Participants were: solitary kidney (n=36) and healthy children (n=57). Renalase levels were measured using the immunoenzymatic method.

Results

Serum and urine renalase levels were significantly lower in patients with a solitary kidney compared to healthy children. Urine renalase/creatinine values were negatively related to serum creatinine and positively related to glomerular filtration rate. Significant correlations between renalase levels and blood pressure were not found.

Conclusions

Prognostic importance of reduced renalase levels in children with a single kidney can only be quantified by further longitudinal study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hegde S, Coulthard MG. Renal agenesis and unilateral nephrectomy: What are the risks of living with a single kidney? Pediatr Nephrol. 2009;24:439–46.

    Article  PubMed  Google Scholar 

  2. Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens. 1988;1:335–47.

    Article  PubMed  CAS  Google Scholar 

  3. Hoy WE, Hughson MD, Bertram JF, Douglas-Denton R, Amann K. Nephron number, hypertension, renal disease and renal failure. J Am Soc Nephrol. 2005;16:2557–64.

    Article  PubMed  Google Scholar 

  4. Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, et al. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J Clin Invest. 2005;115:1275–80.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  5. Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Curr Opin Nephrol Hypertens. 2008;17:181–5.

    Article  PubMed  CAS  Google Scholar 

  6. Ku³aga Z, Litwin M, Grajda A, Ku³aga K, Gurzkowska B, GóŸdŸ M, et al. OLAF Study Group. Oscillometric blood pressure percentiles for Polish normal-weight school-aged children and adolescents. J Hypertens. 2012;30:1942–54.

    Article  Google Scholar 

  7. Rybi-Szumiñska A, Michaluk-Skutnik J, Osipiuk-Rem¿a B, Kossakowska A, Wasilewska A. Normal values for urine renalase excretion in children. Pediatr Nephrol. 2014;29:2191–5.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Westland R, Schreuder MF, Bökenkamp A, Spreeuwenberg MD, van Wijk JA. Renal injury in children with a solitary functioning kidney-the KIMONO study. Nephrol Dial Transplant. 2011;26:1533–41.

    Article  PubMed  Google Scholar 

  9. Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney Int. 2009;76:366–70.

    Article  PubMed  CAS  Google Scholar 

  10. Zbroch E, Malyszko J, Malyszko J, Koc-Zorawska E, Mysliwiec M. Renalase and catecholamines: causative factors or innocent bystansers of hypertension in haemodialysis and peritoneal dialysis patients. ERAEDTA congress, Paris, May 24-27, 2012.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland

    K. Taranta-Janusz, R. Roszkowska & A. Wasilewska

Authors
  1. K. Taranta-Janusz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Roszkowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Wasilewska
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Taranta-Janusz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Taranta-Janusz, K., Roszkowska, R. & Wasilewska, A. Renalase levels in children with solitary functioning kidney. Indian Pediatr 52, 1047–1050 (2015). https://doi.org/10.1007/s13312-015-0771-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-015-0771-2

Keywords

Search

Navigation