Abstract
Objective
IgG and IgA immunocompetence of children with wild poliovirus poliomyelitis and non-polio acute flaccid paralysis.
Methods
932 cases of acute flaccid paralysis, reported in 2008-2009, were tested for presence of polio and non-polio enteroviruses according to the WHO standards. Serum IgA and IgG levels were determined by sandwich ELISA.
Results
Mean (SD) IgA levels [0.87 (0.62)g/L; n=28] of virologically confirmed poliomyelitis cases were lower than those of virus negative [1.21 (0.83)g/L; n=612] and non-polio Enterovirus positive [1.22 (0.79)g/L; n=240] cases of acute flaccid paralysis. No significant difference was observed in the concentration of IgG among these groups.
Conclusion
IgA plays an important role in protection against poliomyelitis.
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Mohanty, M.C., Nalavade, U.P. & Deshpande, J.M. Serum IgG and IgA levels in polio and non-polio acute flaccid paralysis cases in Western Uttar Pradesh, India. Indian Pediatr 52, 220–222 (2015). https://doi.org/10.1007/s13312-015-0610-5
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DOI: https://doi.org/10.1007/s13312-015-0610-5