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Prevalence and risk factors for allergic bronchopulmonary aspergillosis in Indian children with cystic fibrosis

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Abstract

Objectives

Allergic bronchopulmonary aspergillosis (ABPA) is a common complication in patients with cystic fibrosis. This crosssectional study was planned to determine the prevalence and risk factors for ABPA in Indian children with cystic fibrosis.

Methods

Clinical evaluation, spirometry, chest radiograph, sputum, total IgE, specific IgE for Aspergillus fumigatus, IgG precipitins and skin prick tests were done in 33 CF patients.

Results

Prevalence of allergic bronchopulmonary aspergillosis was 18.2% (95% CI 6.9%–35.4%): allergic bronchopulmonary aspergillosis was higher in patients with low cystic fibrosis score, age >12 years, atopy, and eosinophilia.

Conclusion

Prevalence of ABPA is higher in Indian children with cystic fibrosis.

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Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110 029, India

    Varun K. Sharma, D. Raj, R. Lodha & S. K. Kabra

  2. Microbiology, All India Institute of Medical Sciences, New Delhi, India

    I. Xess

Authors
  1. Varun K. Sharma
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  2. D. Raj
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  3. I. Xess
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  4. R. Lodha
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  5. S. K. Kabra
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Correspondence to Varun K. Sharma.

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Sharma, V.K., Raj, D., Xess, I. et al. Prevalence and risk factors for allergic bronchopulmonary aspergillosis in Indian children with cystic fibrosis. Indian Pediatr 51, 295–297 (2014). https://doi.org/10.1007/s13312-014-0396-x

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  • DOI: https://doi.org/10.1007/s13312-014-0396-x

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