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RETRACTED ARTICLE: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer

  • Original Article
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Tumor Biology

This article was retracted on 05 November 2016

Abstract

In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients’ age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Imam Khomeini Hospital Complex and Vali Asr Hospital, Oncology Ward, Tehran University of Medical Sciences, Tehran, Iran

    Setareh Akhavan

  2. Department of Gynecology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran

    Aghdas Safari

  3. Department of Gynecology, Hajar Hospital, AJA University of Medical Sciences, Tehran, Iran

    Sima Azizmohammadi & Susan Azizmohammadi

  4. Department of Biology, California State University Stanislaus, California, USA

    Maysam Aslami

  5. Department of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Emad Yahaghi

  6. Department of Gynecology, Khanevadeh Hospital, AJA University of Medical Sciences, Tehran, Iran

    Mehri Seifoleslami

Authors
  1. Setareh Akhavan
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  2. Aghdas Safari
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  3. Sima Azizmohammadi
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  4. Susan Azizmohammadi
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  5. Maysam Aslami
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  6. Emad Yahaghi
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  7. Mehri Seifoleslami
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Correspondence to Mehri Seifoleslami.

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Additional information

This article has been retracted at the request of the Editor-in-Chief, the International Society of Oncology and BioMarkers (ISOBM) and the Publisher per the Committee on Publication Ethics guidelines. The article shows evidence of irregularities in authorship during the submission process, there is strong reason to believe that the peer review process was compromised and the discussion section of the article shows similarities, which have been for a large part paraphrased, with the results section published in the following article:

Feng M, Wang Y, Chen K, Bian Z, Wu J, et al. (2014) IL-17A Promotes the Migration and Invasiveness of Cervical Cancer Cells by Coordinately Activating MMPs Expression via the p38/NF-kB Signal Pathway. PLoS ONE 9(9): e108502. doi:10.1371/journal.pone.0108502

As such the validity of the content of this article cannot be verified.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-016-5486-z.

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Akhavan, S., Safari, A., Azizmohammadi, S. et al. RETRACTED ARTICLE: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer. Tumor Biol. 37, 10149–10153 (2016). https://doi.org/10.1007/s13277-016-4882-8

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  • DOI: https://doi.org/10.1007/s13277-016-4882-8

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