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miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma

  • Original Article
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Tumor Biology

Abstract

Increasing evidences have revealed that microRNAs regulate various biological processes. However, the roles of miR-761 have not been investigated in ovarian cancer. Here, we found that miR-761 expression was significantly lower in ovarian cancer tissues than in their paired noncancerous tissues. Further study revealed that miR-761 overexpression inhibited the ovarian cancer cell proliferation and invasion. Mechanistically, we demonstrated that the oncogenic properties of miR-761 in ovarian cancer were mediated in part by regulating MSI1 expression. miR-761 and MSI1 are inversely expressed in ovarian cancer tissues. In conclusion, we demonstrated that miR-761 repressed ovarian cancer proliferation and invasion by targeting MSI1.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China

    Can Shi & Zhenyu Zhang

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  1. Can Shi
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  2. Zhenyu Zhang
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Correspondence to Zhenyu Zhang.

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Shi, C., Zhang, Z. miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma. Tumor Biol. 37, 5437–5443 (2016). https://doi.org/10.1007/s13277-015-4377-z

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  • DOI: https://doi.org/10.1007/s13277-015-4377-z

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