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BMP10 inhibited the growth and migration of gastric cancer cells

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Tumor Biology

Abstract

Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis. Dysregulation of BMP has been observed in several cancer types. However, its roles in gastric cancer (GC) remain unknown. In this study, the expression of BMP10 was found to be down-regulated in GC samples. Forced expression of BMP10 in GC cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. BMP10 was shown to negatively regulated beta-catenin/TCF signaling by up-regulating Axin protein level. Taken together, the present study revealed the suppressive function of BMP10 in gastric cancer.

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    Authors and Affiliations

    1. Department of Clinical Medicine, Yancheng Institute of Health Sciences, No. 263, South Jiefang Road, Yancheng, 224005, Jiangsu, China

      Haiming Lei, Xinghua Si & Koulan Han

    2. Department of Gastrointestinal Surgery, Huai’an Hospital Affiliated of Xuzhou Medical College and Huai’an Second People’s Hospital, No. 62, Huai-hai South Road, Huai’an, 223002, Jiangsu, China

      Jian Wang

    3. Department of Medical Oncology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu, China

      Peihua Lu & Tingyan Ruan

    4. Department of Critical Care Medicine, Affiliated Yixing People’s Hospital, Jiangsu University, No. 75, Tongzhenguan Road, Yixing, 214200, Jiangsu, China

      Junjie Lu

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    1. Haiming Lei
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    Correspondence to Junjie Lu.

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    Haiming Lei and Jian Wang contributed equally to this work.

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    Lei, H., Wang, J., Lu, P. et al. BMP10 inhibited the growth and migration of gastric cancer cells. Tumor Biol. 37, 3025–3031 (2016). https://doi.org/10.1007/s13277-015-4116-5

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    • DOI: https://doi.org/10.1007/s13277-015-4116-5

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