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MicroRNA-181 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by targeting Bcl-2

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Tumor Biology

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignancies. In this study, we analyzed the global expression profile of miR-181 in non-small cell lung cancer (NSCLC), as its participation in some other types of cancer has been suggested by previous reports. We found that miR-181 was downregulated both in NSCLC tissues and cell lines. Overexpression of miR-181evidently inhibited A549 cell proliferation, migration, and invasion and promotes cell apoptosis. Moreover, we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression. Taken together, our study implicates important roles of miR-181 in lung cancer pathogenesis and implicates its potential application in cancer therapy.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Huaihaixi Road 241, Shanghai, 200030, China

    Ping Huang, Bo Ye, Yu Yang, Jianxin Shi & Heng Zhao

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  1. Ping Huang
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  2. Bo Ye
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  3. Yu Yang
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  4. Jianxin Shi
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  5. Heng Zhao
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Correspondence to Heng Zhao.

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Huang, P., Ye, B., Yang, Y. et al. MicroRNA-181 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by targeting Bcl-2. Tumor Biol. 36, 3381–3387 (2015). https://doi.org/10.1007/s13277-014-2972-z

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  • DOI: https://doi.org/10.1007/s13277-014-2972-z

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