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Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma

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Tumor Biology

Abstract

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a bona fide long noncoding RNA (lncRNA). LncRNA MALAT1 was discovered as a prognostic factor for lung cancer metastasis but also has been linked to several other human tumor entities. However, little is known about the role of lncRNA MALAT1 in glioma patients. The aim of this study was to identify the role of lncRNA MALAT1 in the pathogenesis of glioma; we analyzed the relationship of lncRNA MALAT1 expression with clinicopathological characteristics in glioma patients. In our results, lncRNA MALAT1 expression was increased in glioma tissues compared with paired adjacent brain normal tissues (P < 0.001). Furthermore, lncRNA MALAT1 was associated significantly with WHO grade (I–II vs. III–IV; P = 0.007) and tumor size (<3 cm vs. T ≥ 3 cm; P = 0.008). However, lncRNA MALAT1 expression was not associated significantly with age (<45 vs. ≥45, P = 0.343), gender (female vs. male, P = 0.196), family history of cancer (yes vs. no, P = 0.665), and tumor location (supratentorial vs. infratentorial, P = 0.170). Moreover, the level of lncRNA MALAT1 expression was markedly correlated with the glioma patients’ overall survival (P < 0.001). Multivariate analysis suggested that increased lncRNA MALAT1 expression was a poor independent prognostic predictor for glioma patients (P = 0.002). In conclusion, lncRNA MALAT1 plays an important role on glioma progression and prognosis and may serve as a convictive prognostic biomarker for glioma patients.

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Authors and Affiliations

  1. Department of Neurosurgery, The Fourth People’s Hospital of Jinan, No. 50 Shifan Road, Jinan, 250000, Shandong, China

    Hong-jie Wang, Xiao-rong Li, Tao Li, Gang Su, Pan Yang & Jian-wen Wu

  2. Department of Neurosurgery, The Ninth People’s Hospital of Xi’an, Xi’an, 710000, Shanxi, China

    Kang-xiao Ma

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  1. Kang-xiao Ma
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  2. Hong-jie Wang
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  3. Xiao-rong Li
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  4. Tao Li
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  5. Gang Su
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  7. Jian-wen Wu
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Correspondence to Jian-wen Wu.

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Hong-jie Wang and Kang-xiao Ma are co-first authors.

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Ma, Kx., Wang, Hj., Li, Xr. et al. Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma. Tumor Biol. 36, 3355–3359 (2015). https://doi.org/10.1007/s13277-014-2969-7

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  • DOI: https://doi.org/10.1007/s13277-014-2969-7

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