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Tumor-infiltrating neutrophils predict poor outcome in adenocarcinoma of the esophagogastric junction

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Tumor Biology

Abstract

Tumor-infiltrating neutrophil (TIN) has been reported to be an independent predictor in multiple tumors, but its role in the development of adenocarcinoma of the esophagogastric junction (AEG) remains unclear. We conducted immunohistochemistry (IHC) to detect the expression of TIN in 113 consecutive patients with primary AEG. The prognostic value and its relationship with clinicopathological characteristics and Ki-67 (a proliferation-associated antigen) expression were analyzed. High level of TIN was related to poor outcome in AEG patients with a hazard ratio (HR) of 3.93 (95 % confidence interval (CI) = 2.14–7.19, p < 0.001) in univariate analysis and a HR of 3.44 (95 % CI = 1.85–6.37, p < 0.001) in multivariate analysis. In addition, TIN was positively correlated with Ki-67 expression (p = 0.008). Our study found that TIN expression was an independent unfavorable predictor in AEG. Furthermore, the relationship between TIN and Ki-67 indicated that TIN was associated with tumor proliferation, which might provide a potential mechanism for why TIN was related to poor outcome in AEG.

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Acknowledgments

The work was supported by the National Natural Science Foundation of China (81301728) and the Provincial Natural Science Foundation of Shandong (ZR2013HZ001).

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Authors and Affiliations

  1. Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, China

    Pingping Hu & Jiajun Du

  2. Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan, China

    Zhaofei Pang, Guanghui Wang, Haifeng Sun & Jiajun Du

  3. Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, China

    Hongchang Shen

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  1. Pingping Hu
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  2. Zhaofei Pang
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  3. Hongchang Shen
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  4. Guanghui Wang
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  5. Haifeng Sun
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  6. Jiajun Du
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Correspondence to Jiajun Du.

Additional information

Pingping Hu and Zhaofei Pang contributed equally to this work.

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Hu, P., Pang, Z., Shen, H. et al. Tumor-infiltrating neutrophils predict poor outcome in adenocarcinoma of the esophagogastric junction. Tumor Biol. 36, 2965–2971 (2015). https://doi.org/10.1007/s13277-014-2927-4

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  • DOI: https://doi.org/10.1007/s13277-014-2927-4

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