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Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview

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Tumor Biology

Abstract

Caveolin-1 plays an important role in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. Increased expression of caveolin-1 in an array of tumors has confirmed its value in prognosis. It has been established that oxidative stress is the main cause for loss of stromal caveolin-1 via autophagy in the tumor microenvironment. In this overview, we attempt to abridge the relationship between caveolin-1 and oral squamous cell carcinoma, taking all the established theories into consideration.

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Acknowledgments

I thank Dr. Akhil A. Shankar, Assistant Professor from the Y.M.T. Dental College & Hospital and Dr. Niharika Swain, Assistant Professor, M.G.M. Dental College & Hospital for their support and critical evaluation of the manuscript.

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  1. Department of Oral Pathology & Microbiology, Institute of Dental Sciences, SOA University, Ghatikia, Sector 8, Bhubaneswar, 751003, India

    Samapika Routray

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Routray, S. Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview. Tumor Biol. 35, 9487–9495 (2014). https://doi.org/10.1007/s13277-014-2482-z

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