Skip to main content
SpringerLink
Log in

Quantitative assessment of the associations between CD28 T > C polymorphism (rs3116496) and cancer risk

  • Research Article
  • Published:
Tumor Biology

Abstract

Many studies have examined the association between CD28 T > C polymorphism (rs3116496) and cancer risk in various populations. However, results remained controversial. To assess this relationship more precisely, a meta-analysis was performed. A comprehensive literature search was performed using the PubMed database for relevant articles published (updated to January 1, 2014). Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association. A total of nine studies were selected for this meta-analysis, including 3,878 cases and 4,424 controls. The results indicated that CD28 T > C polymorphism (rs3116496) was not associated with the risk of cancer in overall population (CC + CT vs. TT, OR = 1.17, 95 %CI = 0.94–1.47, P H = 0.00; CC vs. CT + TT, OR = 1.26, 95 %CI = 0.92–1.73, P H = 0.86; CC vs. TT, OR = 1.27, 95 %CI = 0.92–1.74, P H = 0.85; CT vs. TT, OR = 1.15, 95 %CI = 0.91–1.46, P H = 0.00; and C vs. T, OR = 1.17, 95 %CI = 0.97–1.41, P H = 0.00). In subgroup analysis according to cancer type, no significant association was found in cervical cancer or other cancer. However, in the subgroup analysis by ethnicity, the significant risk was found among Asians (CC + CT vs. TT, OR = 1.51, 95 %CI = 1.24–1.83, P H = 0.05; C vs. T, OR = 1.46, 95 %CI = 1.22–1.74, P H = 0.11), but not among Caucasians. The result of this meta-analysis suggested that CD28 T > C polymorphism (rs3116496) may have an increased risk of cancer in Asians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Lesterhuis WJ, Haanen JB, Punt CJ. Cancer immunotherapy—revisited. Nat Rev Drug Discov. 2011;10:591–600.

    Article  CAS  PubMed  Google Scholar 

  2. Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev. 2009;229:12–26.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Collins M, Ling V, Carreno BM. The B7 family of immune-regulatory ligands. Genome Biol. 2005;6:223.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Kim HJ, Chung JH, Kang S, Kim SK, Cho BS, Kim SD, et al. Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population. J Genet. 2011;90:151–5.

    Article  PubMed  Google Scholar 

  5. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anaqnostopoulos I, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999;397:263–6.

    Article  CAS  PubMed  Google Scholar 

  6. Yoshinaga SK, Whoriskey JS, Khare SD, Sarmiento U, Guo J, Horan T, et al. Tcell co-stimulation through B7RP-1 and ICOS. Nature. 1999;402:827–32.

    Article  CAS  PubMed  Google Scholar 

  7. Bouwhuis MG, Gast A, Figl A, Eggermont AM, Hemminki K, Schadendorf D, et al. Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis? Cancer Immunol Immunother. 2010;59:303–12.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Chen S, Zhang Q, Shen L, Liu Y, Xu F, Li D, et al. Investigation of CD28 gene polymorphisms in patients with sporadic breast cancer in a Chinese Han population in Northeast China. PLoS ONE. 2012;7:e48031.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Chen X, Li H, Qiao Y, Yu D, Guo H, Tan W, et al. Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population. Int J Immunogenet. 2011;38:51–4.

    Article  CAS  PubMed  Google Scholar 

  10. Cheng TY, Lin JT, Chen LT, Shun CT, Wang HP, Lin MT, et al. Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma. J Clin Oncol. 2006;24:3483–9.

    Article  CAS  PubMed  Google Scholar 

  11. Dilmec F, Ozgonul A, Uzunkoy A, Akkafa F. Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer. Int J Immunogenet. 2008;35:317–21.

    Article  CAS  PubMed  Google Scholar 

  12. Ivansson EL, Juko-Pecirep I, Gyllensten UB. Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer. Gynecol Oncol. 2010;116:544–8.

    Article  CAS  PubMed  Google Scholar 

  13. Karabon L, Pawlak E, Tomkiewicz A, Jedynak A, Passowicz-Muszynska E, Zajda K, et al. CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer. Hum Immunol. 2011;72:947–54.

    Article  CAS  PubMed  Google Scholar 

  14. Pawlak E, Karabon L, Wlodarska-Polinska I, Jedynak A, Jonkisz A, Tomkiewicz A, et al. Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population. Hum Immunol. 2010;71:195–200.

    Article  CAS  PubMed  Google Scholar 

  15. Suwalska K, Pawlak E, Karabon L, Tomkiewicz A, Dobosz T, Urbaniak-Kujda D, et al. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. Hum Immunol. 2008;69:193–201.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116001, China

    Jianjun Cong

  2. Department of General Surgery, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China

    Shulong Zhang

  3. Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China

    Xueren Gao

Authors
  1. Jianjun Cong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shulong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xueren Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Shulong Zhang or Xueren Gao.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cong, J., Zhang, S. & Gao, X. Quantitative assessment of the associations between CD28 T > C polymorphism (rs3116496) and cancer risk. Tumor Biol. 35, 9195–9200 (2014). https://doi.org/10.1007/s13277-014-2204-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2204-6

Keywords

Search

Navigation