Skip to main content

Advertisement

SpringerLink
Log in

The prognosis significance of TGF-β1 and ER protein in cervical adenocarcinoma patients with stage Ib ~ IIa

  • Research Article
  • Published:
Tumor Biology

Abstract

The incidence of stage Ib ~ IIa of cervical adenocarcinoma accounts about 60 to 70 % of all patients. This study aims to investigate the prognostic significance of protein estrogen receptor alpha (ERα) and transforming growth factor beta 1 (TGF-β1) level in different glandular epithelia of the cervix. In this study, immunohistochemistry was used to detect ERα and TGF-β1 in carcinomas and incisal margins of 66 cases with cervical adenocarcinoma, 20 cases with normal cervix, and 20 cases with chronic cervicitis. Uni- and multivariate analysis was applied to evaluate the prognostic significance of TGF-β1 and ERα in carcinomas. The results indicated that the positive expression of TGF-β1 in carcinomas was 71.21 %, significantly higher compared to that in the normal cervix (35 %) and chronic cervicitis (55 %) (χ 2 = 8.901, P = 0.012). Similarly, the positive expression of ERα in the carcinomas was 68.18 %, significantly higher compared to the normal cervix (35 %) and chronic cervicitis (50 %) (χ 2 = 7.693, P = 0.021). Both TGF-β1 and ERα in the carcinomas were associated with the vaginal recurrence, infection of HPV, depth of infiltration, and lymphatic metastasis (P < 0.05). The conjugation of TGF-β1 and ERα was an independent prognostic factor for cervical adenocarcinoma. Survival curve showed that the positive TGF-β1 and ERα indicated a short lifetime of patient with cervical adenocarcinoma. In conclusion, the expression of TGF-β1 and ERα protein in the carcinomas had a significant prognostic value in a patient of stage Ib ~ IIa in cervical adenocarcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Alam MS, Ali A, Mehdi SJ, Alyasiri NS, Kazim Z, Batra S, et al. HPV typing and its relation with apoptosis in cervical carcinoma from India population. Tumor Biol. 2012;33(1):17–22.

    Article  Google Scholar 

  2. Umezulike AC, Tabansi SN, Ewunonu HA, Nwana EJ. Epidemiological characteristics of carcinoma of the cervix in the Federal capital Territory of Nigeria. Niger J Clin Pract. 2007;10(1):143–6.

    CAS  PubMed  Google Scholar 

  3. Ronco G, Anttila A. Cervical cancer screening in Europe—changes over the last 9 years. Eur J Cancer. 2009;45(15):2629–31.

    Article  PubMed  Google Scholar 

  4. Li W, Wu H, Song C. TGF-beta1-509C/T (or +869 T/C) polymorphism might be not associated with hepatocellular carcinoma risk. Tumor Biol. 2013;34(5):2675–81.

    Article  Google Scholar 

  5. Li Q, Huang W, Zhou X. Expression of CD34, alpha-smooth muscle actin and transforming growth factor-beta1 in squamous intraepithelial lesions and squamous cell carcinoma of the cervix. J Int Med Res. 2009;37(2):446–54.

    Article  CAS  PubMed  Google Scholar 

  6. Stoica A, Saceda M, Fakhro A, Solomon HB, Fenster BD, Martin MB. The role of transforming growth factor-β in the regulation of estrogen receptor expression in the MCF-7 breast cancer cell line. Endocrinology. 2007;138(4):1498–505.

    Google Scholar 

  7. Cao ZY. Common gynecological cancer treatment guidelines. People’s Health Publishing House, 23-40.

  8. Houvenaeghel G, Buttarelli M, Grégoire E. Locoregional recurrence of cervical and endometrial carcinoma: role of surgical resection. Bull Cancer. 2005;92(9):782–8.

    PubMed  Google Scholar 

  9. Deng W, Tsao SW, Kwok YK, Wong E, Huang XR, Liu S, et al. Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells. Cancer Res. 2008;68(17):7200–9.

    Article  CAS  PubMed  Google Scholar 

  10. Hazelbag S, Kenter GG, Gorter A, Fleuren GJ. Prognostic relevance of TGF-beta1 and PAI-1 in cervical cancer. Int J Cancer. 2004;112(6):1020–8.

    Article  CAS  PubMed  Google Scholar 

  11. Burk RD, Terai M, Gravitt PE, Brinton LA, Kurman RJ, Barnes WA, et al. Distribution of human papillomavirus type 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix. Cancer Res. 2003;63(6):7215–20.

    CAS  PubMed  Google Scholar 

  12. Han CP, Lee MY, Tyan YS, Kok LF, Yao CC, Wang PH, et al. p16 INK4 and CEA can be mutually exchanged with confidence between both relevant three-marker panels (ER/Vim/CEA and ER/Vim/p16 INK4) in distinguishing primary endometrial adenocarcinomas from endocervical adenocarcinomas in a tissue microarray study. Virchows Arch. 2009;455(4):353–61.

    Article  CAS  PubMed  Google Scholar 

  13. Geiger TR, Peeper DS. Metastasis mechanisms. Biochim Biophys Acta. 2009;33(6):765–9.

    Google Scholar 

  14. Kuroishi S, Suda T, Fujisawa T, Ide K, Inui N, Nakamura Y, et al. Epithelial-mesenchymal transition induced by transforming growth factor-beta1 in mouse tracheal epithelial cells. Respirology. 2009;14(6):828–37.

    Article  PubMed  Google Scholar 

  15. Yi J, Hur K, Lee E. TGF beta1-mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line. Eur J Cell Biol. 2002;81(6):457–68.

    Article  CAS  PubMed  Google Scholar 

  16. Macdonald OK, Chen J, Dodson M, Lee CM, Gaffney DK. Prognostic significance of histology and positive lymph node involvement following radical hysterectomy in carcinoma of the cervix. Am J Clin Oncol. 2009;32(4):411–6.

    Article  PubMed  Google Scholar 

  17. Hazelbag S, Kenter GG, Gorter A, et al. Prognostic relevance of TGF-beta1 and PAI-1 in cervical cancer. Int J Cancer. 2004;112(6):1020–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. The Department of Gynecology, The First Affiliated Hospital of Henan University of Science and Technology, 471023, Luoyang, China

    Dong-Mei Fan, Xiao-Yu Tian, Rui-Fang Wang & Juan-Juan Yu

Authors
  1. Dong-Mei Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiao-Yu Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rui-Fang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Juan-Juan Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiao-Yu Tian.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fan, DM., Tian, XY., Wang, RF. et al. The prognosis significance of TGF-β1 and ER protein in cervical adenocarcinoma patients with stage Ib ~ IIa. Tumor Biol. 35, 11237–11242 (2014). https://doi.org/10.1007/s13277-014-2110-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2110-y

Keywords

Search

Navigation