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RETRACTED ARTICLE: FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Cortactin, an actin-interacting protein, is implicated in cytoskeletal architecture and often amplified in several types of cancer including gastric adenocarcinomas. Downregulation of cortactin decreases cell migration and invasion. However, how to regulate cortactin in gastric cancer remains largely unknown. Here, we report that FBXL5 interacts with and targets cortactin for ubiquitylation and subsequent proteasomal degradation. Furthermore, we showed that FBXL5-induced cortactin degradation is mediated by extracellular regulated signal kinase (ERK). Serine phosphorylation sites mutant, cortactinS405A/S418A, prevent FBXL5-induced cortactin degradation. Moreover, CortactinS405A/S418A exhibited stronger effects in promoting gastric cancer cell migration when compared to wild-type cortactin. Taken together, our data suggested a novel molecular mechanism for the negative regulation of cortactin by FBXL5 in gastric cancer cells migration.

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Authors and Affiliations

  1. Department of General Surgery, The First People’s Hospital Affiliated to Shanghai JiaoTong University, Shanghai, 200080, China

    Gang Cen & Wei-Dong Wu

  2. Department of oncology, The First People’s Hospital Affiliated to Shanghai JiaoTong University, Shanghai, China

    Hong-Hua Ding

  3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China

    Bin Liu

Authors
  1. Gang Cen
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  2. Hong-Hua Ding
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  3. Bin Liu
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  4. Wei-Dong Wu
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Corresponding author

Correspondence to Wei-Dong Wu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Cen, G., Ding, HH., Liu, B. et al. RETRACTED ARTICLE: FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration. Tumor Biol. 35, 8633–8638 (2014). https://doi.org/10.1007/s13277-014-2104-9

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  • DOI: https://doi.org/10.1007/s13277-014-2104-9

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