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Recent toxicological investigations of metal or metal oxide nanoparticles in mammalian models in vitro and in vivo: DNA damaging potential, and relevant physicochemical characteristics

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Abstract

Concomitant with the increase in production and application of various nanomaterials, researches on their cytotoxic and genotoxic potential have become well established, as exposure to these nanoscaled materials may contribute to detrimental health effects. Positive indications of the damaging effects of nanoparticles on DNA are likely to be inconsistent in in vitro systems, and thus the implementation of in vivo investigations has been achieved. This review summarizes the current results, both in vitro and in vivo, of the genotoxic effects of potential metal or metal oxide nanoparticles, including the oxides of aluminium, iron, silica, titanium, and zinc, as well as silver, gold, cobalt, quantum dots, and so forth. They present indications of different types of DNA damage, ranging from chromosomal aberrations, through DNA strand breaks, oxidative DNA damage, to mutations. Their toxicological profiles are definitely associated with physicochemical characters, depending upon the characterization methods by which they are analyzed, in particular, microscopy techniques. Besides physicochemical properties, we also discuss significant parameters that may influence genotoxic response, including toxicity assays/endpoint tests, exposure duration and route of exposure, and experimental conditions. We describe advantages and disadvantages of particular characterization methods, as well as the appropriateness of methodologies for investigating physicochemical characters. Therefore, recommendations on particle characterization are further emphasized, to provide better understanding of genotoxic potential.

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Authors and Affiliations

  1. Faculty of Environment and Resource Studies, Mahidol University, 999 Phuttamonthon 4 Rd., Phuttamonthon District, Nakhon Pathom, 73170, Thailand

    Preeyaporn Koedrith & Rattana Boonprasert

  2. Department of Life Science, Institute of Environmental Medicine, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul, 100-715, Korea

    Jee Young Kwon & Young Rok Seo

  3. Graduate School of Environmental Studies, Kwangwoon University, 20 Gwangun-ro, Nowon-gu, Seoul, 139-701, Korea

    Im-Soon Kim

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  1. Preeyaporn Koedrith
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  2. Rattana Boonprasert
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  3. Jee Young Kwon
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  4. Im-Soon Kim
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  5. Young Rok Seo
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Correspondence to Im-Soon Kim or Young Rok Seo.

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These authors contributed equally to this work.

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Koedrith, P., Boonprasert, R., Kwon, J.Y. et al. Recent toxicological investigations of metal or metal oxide nanoparticles in mammalian models in vitro and in vivo: DNA damaging potential, and relevant physicochemical characteristics. Mol. Cell. Toxicol. 10, 107–126 (2014). https://doi.org/10.1007/s13273-014-0013-z

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  • DOI: https://doi.org/10.1007/s13273-014-0013-z

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