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Synergic effects of the ApoC3 and ApoA4 polymorphisms on the risk of hypertension

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Abstract

The apolipoprotein (Apo) C3 and A4 genes, which are members of the ApoA1/C3/A4/A5 gene cluster, play important roles in lipid metabolism. Despite their importance, studies on the association between these polymorphisms in patients with hypertension are rare. In this study, we examined the associations of ApoC3 (−482C>T rs2854117, −455T>C rs2854116 and 3238G>C rs5128) and ApoA4 1687A>G rs5104 polymorphisms in Korean hypertensive patients. Three hundred and forty patients with hypertension and 515 healthy normotensive subjects were studied. ApoC3 and ApoA4 polymorphisms in the subjects were analyzed by polymerase chain reaction and restriction fragment length polymorphism. The four polymorphisms were not associated with susceptibility to hypertension. However, several haplotypes constructed from four polymorphisms of the ApoC3 and ApoA4 genes were associated with susceptibility to hypertension. With respect to the clinical parameters of hypertension, the −482C>T and −455T>C polymorphisms of the ApoC3 gene were associated with abnormal body mass index (P = 0.024) and triglyceride levels (P = 0.033) in the hypertensive group, respectively. Based on these results, the ApoC3 and ApoA4 polymorphisms might affect synergically susceptibility to hypertension in Koreans.

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Acknowledgements

This work was supported by a research grant from Jeju National University Hospital in 2014.

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Authors and Affiliations

  1. Department of Laboratory Medicine, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea

    Sung Ha Kang & Young Ree Kim

  2. Department of Science Education, Teachers College, Jeju National University, Jeju, 63294, Republic of Korea

    Seung-Ho Hong

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  1. Sung Ha Kang
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  2. Young Ree Kim
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Correspondence to Seung-Ho Hong.

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Sung Ha Kang, Young Ree Kim and Seung-Ho Hong declare that there is no conflict of interest.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional standards. The study was approved by the Institutional Review Board of Jeju National University Hospital (JEJUNH 2016-06-008).

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Kang, S.H., Kim, Y.R. & Hong, SH. Synergic effects of the ApoC3 and ApoA4 polymorphisms on the risk of hypertension. Genes Genom 39, 1163–1172 (2017). https://doi.org/10.1007/s13258-017-0606-8

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