Skip to main content
SpringerLink
Log in

Combination of conjugated polyelectrolytes and biomolecules: A new optical platform for highly sensitive and selective chemo- and biosensors

  • Reviews
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Conjugated polyelectrolytes (CPEs) have been studied extensively as the optical platform for chemo- and biosensor applications with high sensitivity by virtue of their light harvesting effect. A range of fluorescent CPEsbased sensing schemes have been developed by utilizing fluorescence quenching via photo-induced electron transfer and fluorescence resonance energy transfer, etc. Highly sensitive and selective detection assays can be realized by combining the tunable optical properties of synthetic CPEs with specific binding characteristics of biomolecules (such as aptamer, antibody, protein, etc.). This article reviews the range of fluorescence-based optical assays with the CPEs-biomolecule complex as a signaling platform with in situ detection, remarkable sensitivity and selectivity, etc.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. T. McQuade, A. E. Pullen, and T. M. Swager, Chem. Rev., 100, 2537 (2000).

    Article  CAS  Google Scholar 

  2. S. W. III. Thomas, G. D. Joly, and T. M. Swager, Chem. Rev., 107, 1339 (2007).

    Article  CAS  Google Scholar 

  3. B. H. Lee, I. H. Jung, H. Y. Woo, H.-K. Shim, G. Kim, and K. Lee, Adv. Funct. Mater. 24, 1100 (2013).

    Article  Google Scholar 

  4. W. Lee, J. H. Seo, and H. Y. Woo, Polymer, 54, 5104 (2013).

    Article  CAS  Google Scholar 

  5. Q. Zhou and T. M. Swager, J. Am. Chem. Soc., 117, 7017 (1995).

    Article  CAS  Google Scholar 

  6. Y. C. Shin, J. H. Lee, J.-E. Jeong, B. Kim, E. J. Lee, O. S. Jin, T. G. Jung, J. J. Lee, H. Y. Woo, and D.-W. Han, Biotechnol. Appl. Biochem. 60, 580 (2013).

    Article  CAS  Google Scholar 

  7. A. Duarte, K.-Y. Pu, B. Liu, and G. C. Bazan, Chem. Mater., 23, 501 (2011).

    Article  CAS  Google Scholar 

  8. L. Chen, D. W. McBranch, H.-L. Wang, R. Helgeson, F. Wudi and D. G. Whitten, Proc. Natl. Acad. Sci. U.S.A., 96, 12287 (1999).

    Article  CAS  Google Scholar 

  9. K. Lee, L. K. Povlich, and J. Kim, Adv. Funct. Mater., 17, 2580 (2007).

    Article  CAS  Google Scholar 

  10. V. S. Le, B. Kim, W. Lee, J.-E. Jeong, R. Yang, and H. Y. Woo, Macromol. Rapid Commun., 34, 772 (2013).

    Article  CAS  Google Scholar 

  11. B. L. Nguyen, J.-E. Jeong, I. H. Jung, B. Kim, V. S. Le, I. Kim, K. Kyhm, and H. Y. Woo, Adv. Funct. Mater. (2013). DOI: 10.1002/adfm.201301515 (in press)

    Google Scholar 

  12. J. You, J. Kim, T. Park, B. Kim, and E. Kim, Adv. Funct. Mater., 22, 1417 (2012).

    Article  CAS  Google Scholar 

  13. B. S. Gaylord, A. J. Heeger, and G. C. Bazan, Proc. Natl. Acad. Sci. U.S.A., 99, 10954 (2002).

    Article  CAS  Google Scholar 

  14. B. S. Gaylord, MR. massie, S. C. Feinstein, and G. C. Bazan, Proc. Natl. Acad. Sci. U.S.A., 102, 34 (2005).

    Article  CAS  Google Scholar 

  15. A. D. Ellington and J. W. Szostak, Nature, 346, 818 (1990).

    Article  CAS  Google Scholar 

  16. T. Hermann and D. J. Patel, Science, 287, 820 (2000).

    Article  CAS  Google Scholar 

  17. N. Hamaguchi, A. Ellington, and M. Stanton, Anal. Biochem., 294, 126 (2001).

    Article  CAS  Google Scholar 

  18. S. D. Jayasena, Clin. Chem., 45, 1628 (1999).

    CAS  Google Scholar 

  19. R. Stoltenburg, C. Reinemann, and B. Strehlitz, Biomol. Eng., 24, 381 (2007).

    Article  CAS  Google Scholar 

  20. I. Burbulis, K. Yamaguchi, R. Yu, O. Resnekov, and R. Brent, Nature Methods, 4, 1011 (2007).

    Article  CAS  Google Scholar 

  21. H.-C. Kuo, C.-F. Cheng, R. B. Clark, J.J.-C. Lin, J.L.-C. Lin, M. Hoshijima, V. T. B. Nguyen-Tran, Y. Gu, Y. Ikeda, P.-H. Chu, J. Jr. Ross, W. R. Giles, and K. R. Chien, Cell, 107, 801 (2001).

    Article  CAS  Google Scholar 

  22. W. Walz, Neurochem. Int., 36, 291 (2000).

    Article  CAS  Google Scholar 

  23. M. Teresa, S. R. Gomes, K. S. Tavares, and J. A. B. P. Oliveira, Analyst, 125, 1983 (2000).

    Article  CAS  Google Scholar 

  24. H. He, M. A. Mortellaro, M. J. P. Leiner, R. J. Fraatz, and J. K. Tusa, J. Am. Chem. Soc., 125, 1468 (2003).

    Article  CAS  Google Scholar 

  25. J. R. Williamson, Curr. Opin. Struct. Biol., 3, 357 (1993).

    Article  CAS  Google Scholar 

  26. S. Neidle and G. Parkinson, Nat. Rev. Drug Discov., 1, 383 (2002).

    Article  CAS  Google Scholar 

  27. H. Arthanari and P. H. Bolton, Chem. Biol., 8, 221 (2001).

    Article  CAS  Google Scholar 

  28. D. E. Gilbert and J. Feigon, Curr. Opin. Struct. Biol., 9, 305 (1999).

    Article  CAS  Google Scholar 

  29. A. Siddiqui-Jain, C. L. Grand, D. J. Bearss, and L. H. Hurley, Proc. Natl. Acad. Sci. U.S.A., 99, 11593 (2002).

    Article  CAS  Google Scholar 

  30. F. He, Y. Tang, M. Yu, F. Feng, L. An, H. Sun, S. Wang, Y. Li, D. Zhu, and G. C. Bazan, J. Am. Chem. Soc., 128, 6764 (2006).

    Article  CAS  Google Scholar 

  31. H. Xu, S.-L. Gao, Q. Yang, D. Pan, L.-H. Wang and C.-H. Fan, Acs Appl. Mater. Interfaces, 2, 3211 (2010).

    Article  CAS  Google Scholar 

  32. H. A. Ho and M. Leclerc, J. Am. Chem. Soc., 126, 1384 (2004).

    Article  CAS  Google Scholar 

  33. B. Kim, I. H. Jng, M. Kang, H.-K. Shim, and H. Y. Woo, J. Am. Chem. Soc., 134, 3133 (2012).

    Article  CAS  Google Scholar 

  34. L. J. Bowman, C. D. Anderson, and W. C. Chapman, Semin. Thromb. Hemost., 36, 477 (2010).

    Article  CAS  Google Scholar 

  35. A. Nishino, M. Suzuki, H. Ohtani, O. Motohashi, K. Umezawa, H. Nagura, and T. Yoshimoto, J. Neurotrauma, 10, 167 (1993).

    Article  CAS  Google Scholar 

  36. H. Inuyama, T. Saito, J. Takagi, and Y. Saito, J. Cell. Physio., 173, 406 (1997).

    Article  CAS  Google Scholar 

  37. F. Pu, Z. Huang, D. Hu, J. Ren, S. Wang, and X. Qu, Chem. Commun., 7357 (2009).

  38. S. Y. Yan, R. Huang, Y. Zhou, M. Zhang, M. Deng, X. Wang, X. Weng, and X. Zhou, Chem. Commun., 47, 1273 (2011).

    Article  CAS  Google Scholar 

  39. Y. Y. Wang and B. Liu, Langmuir, 25, 12787 (2009).

    Article  CAS  Google Scholar 

  40. Y. Y. Wang, K. Y. Pu, and B. Liu, Langmuir, 26, 10025 (2010).

    Article  CAS  Google Scholar 

  41. F. Xia, X. Zuo, R. Yang, Y. Xiao, D. Kang, A. Vallee-elisle, X. Gong, A. J. Heeger, and K. W. Plaxco, J. Am. Chem. Soc., 132, 1252 (2010).

    Article  CAS  Google Scholar 

  42. M. N. Stojanovic, P. de Prada, and D. W. Landry, J. Am. Chem. Soc., 123, 4928 (2001).

    Article  CAS  Google Scholar 

  43. F. Xia, X. Zuo, R. Yang, Y. Xiao, D. Kang, A. Vallee-Belisle, X. Gong, J. D. Yuen, B. B. Y. Hsu, A. J. Heeger, and K. W. Plaxco, Proc. Natl. Acad. Sci. U.S.A., 107, 10837 (2010).

    Article  CAS  Google Scholar 

  44. B. Li, C. Qin, T. Li, L. Wang, and S. Dong, Anal. Chem., 81, 3544 (2009).

    Article  CAS  Google Scholar 

  45. G. W. Litman, J. P. Rast, M. J. Shamblott, R. N. Haire, M. Hulst, W. Roess, R. T. Litman, K. R. Hinds-Frey, A. Zilch, and C. T. Amemiya, Mol. Biol. Evol., 10, 60 (1993).

    CAS  Google Scholar 

  46. P. S. Petrou, C. Mastichiadis, I. Christofidis, and S. E. Kakabakos, Anal. Chem., 79, 647 (2007).

    Article  CAS  Google Scholar 

  47. J. Wang, G. Liu, M. H. Engelhard, and Y. Lin, Anal. Chem., 78, 6974 (2006).

    Article  CAS  Google Scholar 

  48. X. Zhang, Y. Wu, Y. Tu, and S. Liu, Analyst, 133, 485 (2008).

    Article  CAS  Google Scholar 

  49. L. S. Wan, B. B. Ke, and Z. K. Xu, Enzyme Microb. Technol., 42, 332 (2008).

    Article  CAS  Google Scholar 

  50. K. Lee, J. Lee, E. J. Jeong, A. Kronk, K. S. J. Elenitoba-Johnson, M. S. Lim, and J. Kim, Adv. Mater., 24, 2479 (2012).

    Article  CAS  Google Scholar 

  51. C. F. Wu, T. Schneider, M. Zeigler, J. Yu, P. G. Schiro, D. R. Burnham, J. D. McNeill, and D. T. Chiu, J. Am. Chem. Soc., 132, 15410 (2010).

    Article  CAS  Google Scholar 

  52. Y. Y. Wang and B. Liu, Biosens. Bioelectron., 24, 3293 (2009).

    Article  CAS  Google Scholar 

  53. D. Wang, X. Gong, P. S. Heeger, F. Rininsland, G. C. Bazan and A. J. Heeger, Proc. Natl. Acad. Sci. U.S.A., 99, 49 (2002).

    Article  CAS  Google Scholar 

  54. A. Gutteridge and J. M. Thornton, Trends Biochem. Sci., 30, 622 (2005).

    Article  CAS  Google Scholar 

  55. A. B. Fulton and W. B. Isaacs, Bioessays, 13, 157 (1991).

    Article  CAS  Google Scholar 

  56. R. Westermeier and R. Marouga, Biosci. Rep., 25, 19 (2005).

    Article  CAS  Google Scholar 

  57. N. M. Green, Advan. Protein Chem., 29, 85 (1975).

    Article  CAS  Google Scholar 

  58. A. Holmberg, A. Blomstergren, O. Nord, M. Lukacs, J. Lundeberg and M. Uhlen, Electrophoresis, 26, 501 (2005).

    Article  CAS  Google Scholar 

  59. E. K. Ji, D. L. Wu, and K. S. Schanze, Langmuir, 26, 14427 (2010).

    Article  CAS  Google Scholar 

  60. L. An, Y. Tang, S. Wang, Y. Li, and D. Zhu, Macromol. Rapid Commun., 27, 993 (2006).

    Article  CAS  Google Scholar 

  61. N. Sharon and H. Lis, Science, 177, 949 (1972).

    Article  CAS  Google Scholar 

  62. Y. C. Lee and R. T. Lee, Acc. Chem. Res., 28, 321 (1995).

    Article  CAS  Google Scholar 

  63. R. A. Dwek, Chem. Rev., 96, 683 (1996).

    Article  CAS  Google Scholar 

  64. H. Lis and N. Sharon, Chem. Rev., 98, 637 (1998).

    Article  CAS  Google Scholar 

  65. E. E. Simanek, G. J. McGarvey, J. A. Jablonowski, and C.-H. Wong, Chem. Rev., 98, 833 (1998).

    Article  CAS  Google Scholar 

  66. J. Shi, L. Cai, K.-Y. Pu, and B. Liu, Chem. Asian J., 5, 301 (2010).

    Article  CAS  Google Scholar 

  67. K.-Y. Pu, J. Shi, L. Wang, L. Cai, G. Wang, and B. Liu, Macromolecules, 43, 9690 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cogno-Mechatronics Engineering, Pusan National University, Gyeongnam, 627-706, Korea

    Ji-Eun Jeong, Shin-Jae Woo, Van Sang Le, Hyejin Choi & Han Young Woo

Authors
  1. Ji-Eun Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shin-Jae Woo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Van Sang Le
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hyejin Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Han Young Woo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Han Young Woo.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jeong, JE., Woo, SJ., Le, V.S. et al. Combination of conjugated polyelectrolytes and biomolecules: A new optical platform for highly sensitive and selective chemo- and biosensors. Macromol. Res. 22, 461–473 (2014). https://doi.org/10.1007/s13233-014-2080-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-014-2080-3

Keywords

Search

Navigation