Skip to main content
Log in

Comparative Study of USG and MRI in Evaluation of Isthmocele

  • Original Article
  • Published:
The Journal of Obstetrics and Gynecology of India Aims and scope Submit manuscript

Abstract

Objective

To study the presence of isthmocele in post-cesarean women using USG and MRI and its correlation with risk factors.

Method

This was a prospective observational study. A total of 90 patients were enrolled at the time of discharge of cesarean delivery and were advised to come for follow-up at 3–4 months for detection of isthmocele. A total of 82 patients reported for follow-up, and TVS and MRI Pelvis were done for visualization of isthmocele. If isthmocele was diagnosed, its correlation with risk factors was studied.

Results

On TVS isthmocele was present in 11 patients and on MRI in 16 patients. Detection rate was 77.07% in comparison with previous studies. Compared to MRI, sensitivity of USG was 68.75%; however, the specificity and positive predictive value for both were 100%. The negative predictive value for USG compared to MRI was 92.96%. Shape of the isthmocele was triangular in most women. Obesity, prior history of cesarean delivery, elective cesarean, gestational diabetes, preeclampsia and prolonged active labor were associated with development of isthmocele.

Conclusion

The study concluded that yield of diagnosis of isthmocele by MRI was better than TVS but not statistically significant. Further study with large sample size is needed to identify the best tool for diagnosis of isthmocele. Obesity, gestational diabetes, preeclampsia, prior history of cesarean, elective cesarean and prolonged active labor were associated with development of isthmocele.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Betran AP, Ye J, Moller A-B, Zhang J, Gülmezoglu AM, Torloni MR. The increasing trend in cesarean section rates: global, regional and national estimates: (1990–2014). PLoS ONE. 2016;11(2):e0148343.

    Article  Google Scholar 

  2. Fouedji JH, Fouelifack YF, Esiene A, Tatah FM, Essiben F, Mbu RE. Maternal and fetal outcome in cesarean section in three referral hospital in yaoundé: elective versus emergency. What are the places of the type of anaesthesia and the experience of the surgeon? J Biomed Sci. 2020;21(2):39–45.

    Google Scholar 

  3. Ramadan KM, Kassem S, Itani S, Sinno L, Hussein S, Chahin R, et al. Incidence and risk factors of uterine scar dehiscence identified at elective repeat cesarean delivery: a case-control study. J Clin Gynecol Obstet. 2018;7(2):37–42.

    Article  Google Scholar 

  4. Vikhareva O, Rickle GS, Lavesson T, Nedopekina E, Brandell K, Salvesen KÅ. Hysterotomy level at cesarean section and occurrence of large scar defects: a randomized single-blind trial. Ultrasound Obstet Gynecol. 2019;53(4):438–42.

    Article  CAS  Google Scholar 

  5. Pędraszewski P, Wlazlak E, Panek W, Surkont G. Cesarean scar pregnancy a new challenge for obstetricians. J Ultrason. 2018;18(72):56–62.

    Article  Google Scholar 

  6. Kremer TG, Ghiorzi IB, Dibi RP. Isthmocele: an overview of diagnosis and treatment. Revista da Associação Médica Brasileira. 2019;65(5):714–21.

    Article  Google Scholar 

  7. Mariya T, Umemoto M, Sugita N, Suzuki M, Saito T. Recurrent massive uterine bleeding from a cesarean scar treated successfully by laparoscopic surgery. Gynecol Minim Invasive Ther. 2019;8(1):36.

    Article  Google Scholar 

  8. Patounakis G, Ozcan MC, Chason RJ, Norian JM, Payson M, DeCherney AH, et al. Impact of a prior cesarean delivery on embryo transfer: a prospective study. Fertil Steril. 2016;106:311–6.

    Article  Google Scholar 

  9. Antila-Långsjö RM, Mäenpää JU, Huhtala HS, Tomás EI, Staff SM. Cesarean scar defect: a prospective study on risk factors. ACOG. 2018;219(5):458.

    Google Scholar 

  10. Van der Voet LF, Jordans IP, Brölmann HA, Veersema S, Huirne JA. Changes in the uterine scar during the first year after a Caesarean section: a prospective longitudinal study. Gynecol Obstet Invest. 2018;83(2):164–70.

    Article  Google Scholar 

  11. Wong WS, Fung WT. Magnetic resonance imaging in the evaluation of cesarean scar defect. Gynecol Minim Invasive Ther. 2018;7(3):104–7.

    Article  Google Scholar 

  12. Rosa F, Perugin G, Schettini D, Romano N, Romeo S, Podestà R, Guastavino A, Casaleggio A, Gandolfo N. Imaging findings of cesarean delivery complications: cesarean scar disease and much more. Insights Imaging. 2019;10(1):98.

    Article  CAS  Google Scholar 

  13. Alosh MK, Farag MA, Omar SB. Influence of the number of previous cesarean sections on lower uterine segment state. Benha Med J. 2018;35:111–4.

    Google Scholar 

  14. Stegwee SI, Beij A, de Leeuw RA, Mokkink LB, van der Voet LF, Huirne JA. Niche-related outcomes after caesarean section and quality of life: a focus group study and review of literature. Qual Life Res. 2019;16:1–3.

    Google Scholar 

  15. Zarei F, Soleimaninejad M. Role of growth factors and biomaterials in wound healing. Artif Cells Nanomed Biotechnol. 2018;46(sup1):906–11.

    Article  CAS  Google Scholar 

  16. Park IY, Kim MR, Lee HN, Gen Y, Kim MJ. Risk factors for Korean women to develop an isthmocele after a cesarean section. BMC Pregnancy Childbirth. 2018;18(1):162.

    Article  CAS  Google Scholar 

  17. Vervoort AJ, Uittenbogaard LB, Hehenkamp WJ, Brolmann HA, Mol BW, Huirne JA. Why do niches develop in caesarean uterine scars? Hypotheses on the aetiology of niche development. Hum Reprod. 2015;30(12):2695–702.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Karli P, Şahin B, Fadıl KA. The incidence of isthmocele may be higher than reported. Int J of Surg Med. 2018;2(3):283–7.

    Google Scholar 

Download references

Funding

We, Taru Gupta, Dr Khushbu Singal, Dr Nupur Gupta, Dr Supreeti Kohli, Dr Monica Kanyal are submitting a manuscript titled “Comparative study of USG and MRI in evaluation of Isthmocele’ and we are responsible for disclosing all financial and personal relationships that might bias their work. We also declare that this study was conducted in a postgraduate institute and no funding was involved.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Khushbu Singal.

Ethics declarations

Conflict of interest

The author declares that they have no conflict of interest.

Ethical Approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national). An ethical clearance has also been taken from the institutional ethical committee.

Informed Consent

Informed Consent in Studies with Human Subjects All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. This article does not contain any studies with animal subjects.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Dr Taru Gupta, MS, DNB, is an Professor and Head, Department of Obstetrics and Gynaecology, ESI PGIMSR Basaidarapur New Delhi; Dr Khushbu Singal is an Post graduate student, Department of Obstetrics and Gynaecology, ESI PGIMSR Basaidarapur New Delhi; Dr Nupur Gupta, MS is an Associate Professor, Department of Obstetrics and Gynaecology, ESI PGIMSR Basaidarapur New Delhi; Dr Supreeti Kohli, MD is an Professor, Department of Radiology, ESI PGIMSR Basaidarapur New Delhi; Dr Monica Kanyal is an Post graduate student, Department of Obstetrics and Gynaecology, ESI PGIMSR Basaidarapur New Delhi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gupta, T., Singal, K., Gupta, N. et al. Comparative Study of USG and MRI in Evaluation of Isthmocele. J Obstet Gynecol India 71, 292–296 (2021). https://doi.org/10.1007/s13224-021-01433-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13224-021-01433-w

Keywords

Navigation