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Seroprevalence and Efficacy of Prevention of Parent to Child Transmission Program Over a Decade in a Tertiary Care Hospital in Mumbai, Maharashtra

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Abstract

Background

Parent to child transmission is the major mode of spread of HIV. An effective national health program (PPTCT) has been designed under NACO which helps in reducing the spread of HIV by vertical transmission and improving the life of the women and her baby.

Methods

A retrospective study was done at a tertiary care hospital, including pregnant women registered and delivered, and those who came directly in labour at the hospital during a period of 10 years from January 2010 to December 2019. Pretest counselling, HIV testing, Post-test counselling were done, and antiretroviral prophylaxis was given as per the NACP guidelines. Sociodemographic characteristics, obstetric outcome and efficacy of PPTCT services were analysed.

Results

Out of the 63,947 antenatal mothers included, 61,061 (95.4%) accepted HIV testing. 177 of these tested positive (0.289%) with a significant reduction in the seroprevalence over the decade. Majority of seropositive women were primigravida; housewives from urban areas, from low income and educational background and with no history of any contraceptive use. Out of 718 live births, the MTCT rate was found to be 4.5% at 6 weeks over the whole decade and was noted to be 1.8 % at 18 months which is well within the goal of PPTCT program and hence elucidating the success. Seventy-four spouses of the 177 seropositive women tested positive, 55 tested negative and 49 did not undergo the HIV testing. Decline in the number of partners not undergoing testing was elicited. The discordant couple rate in the study was 31% and showed variable trend over the decade.

Conclusions

Our study has observed an overall increase in efficacy of PPTCT in terms of increased utilization of PPTCT through the decade, decrease in the vertical transmission and seroprevalence rate, increase in the acceptance rates of HIV testing by partner almost conquering the goal of NACO.

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Acknowledgements

Department of Obstetrics and Gynaecology, Lokmanya Tilak Medical College, Mumbai, India. Mrs. Radha, PPTCT counsellor, Lokmanya Tilak Medical college and General Hospital, Mumbai , India

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Lokmanya Tilak Medical College, Mumbai, India

    Deepali Swapnil Kapote (Assisstant Professor), Michelle N. Fonseca (Professor), Arun Harishchandra Nayak (Professor and Head of Department), Swathi H. Vishwabharati & Apeksha Mohite

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  1. Deepali Swapnil Kapote
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  2. Michelle N. Fonseca
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  3. Arun Harishchandra Nayak
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  4. Swathi H. Vishwabharati
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Correspondence to Swathi H. Vishwabharati.

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Research involving human participants/animals

The study was approved by the institutional research ethics committee-LTMMC and LTMGH , Mumbai and the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.

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Deepali Swapnil Kapote is a Assisstant Professor, Department of Obstetrics and Gynaecology, Lokmanya Tilak Medical College, Mumbai, India. Michelle N. Fonseca is a Professor Addl. and HOU, Department of Obstetrics and Gynaecology, Lokmanya Tilak Medical College, Mumbai, India. Arun Harishchandra Nayak is a Professor and Head of Department, Department of Obstetrics and Gynaecology, Lokmanya Tilak Medical College, Mumbai, India. H. V. Swathi is a Senior Resident, Department of Obstetrics and Gynaecology, Lokamanya Tilak Municipal Medical College and General Hospital, Mumbai, India. Apeksha Mohite is a Post graduate student, Department of Obstetrics and Gynaecology, Lokamanya Tilak Municipal Medical College and General Hospital, Mumbai, India.

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Kapote, D.S., Fonseca, M.N., Nayak, A.H. et al. Seroprevalence and Efficacy of Prevention of Parent to Child Transmission Program Over a Decade in a Tertiary Care Hospital in Mumbai, Maharashtra. J Obstet Gynecol India 71, 501–509 (2021). https://doi.org/10.1007/s13224-021-01428-7

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