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An Evaluation of Applicability of Salivary Uric Acid Measurement in Preeclampsia and Normal Pregnancy and Its Correlation with Serum Uric Acid

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Abstract

Purpose

Hypertensive disorders complicate 5–10% of all pregnancies and contribute greatly to maternal morbidity and mortality. There are various biomarkers for detection of preeclampsia. Several studies have reported that positive correlation exists between serum uric acid (UA) levels and adverse maternal and fetal outcome. Significant advances have been made toward validation of salivary biomarkers. We conducted this study to determine levels of salivary UA and its correlation with serum UA normal pregnancy and preeclampsia.

Methods

Present cross-sectional study was conducted in tertiary care teaching hospital in North India. One hundred and fifty participants were divided into control group (50 healthy non-pregnant females), study group I (50 normotensive pregnant females), study group II (50 pregnant females with preeclampsia), and both salivary and serum UA was estimated at the same time.

Results

Saliva UA of study group II (4.86 ± 2.37 mg/dl) was significantly higher (p < 0.001) than that of control group (2.09 ± 1.33 mg/dl) and study group I (3.32 ± 1.77 mg/dl). Serum UA of study group II (6.63 + 2.78 mg/dl) was significantly higher (p < 0.001) than that of control group (2.94 + 1.94 mg/dl) and also study group I (5.18 + 2.31 mg/dl) (p = 0.0006).

Conclusion

UA is present in the saliva of women with preeclampsia and has linear correlation with serum UA. Therefore, salivary UA can be used in place of invasive serum UA to monitor women with preeclampsia. Saliva collection is easy, noninvasive and cost-effective. Salivary UA testing may be useful for monitoring preeclampsia at home-based and hospital setting.

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Abbreviations

UA:

Uric acid

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, King George’s Medical University, Lucknow, Uttar Pradesh, India

    Urmila Singh, Vandana Solanki, Seema Mehrotra & Ruchita Sharma

Authors
  1. Urmila Singh
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  2. Vandana Solanki
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  3. Seema Mehrotra
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  4. Ruchita Sharma
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Corresponding author

Correspondence to Vandana Solanki.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5).

Informed Consent

Informed consent was obtained from all patients for being included in the study.

Additional information

Urmila Singh is DGO, MD, FICMCH, FICOG, MAMS, Professor and Unit Head in the Department of Obstetrics and Gynaecology, King George´s Medical University, Lucknow, Uttar Pradesh, India; Vandana Solanki is Assistant Professor at Department of Obstetrics and Gynaecology, King George´s Medical University, Lucknow, Uttar Pradesh, India; Seema Mehrotra is Professor at Department of Obstetrics and Gynaecology, King George´s Medical University, Lucknow, Uttar Pradesh, India; Ruchita Sharma is Resident at Department of Obstetrics and Gynaecology, King George´s Medical University, Lucknow, Uttar Pradesh, India.

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Singh, U., Solanki, V., Mehrotra, S. et al. An Evaluation of Applicability of Salivary Uric Acid Measurement in Preeclampsia and Normal Pregnancy and Its Correlation with Serum Uric Acid. J Obstet Gynecol India 69, 62–68 (2019). https://doi.org/10.1007/s13224-018-1124-6

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  • DOI: https://doi.org/10.1007/s13224-018-1124-6

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