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Current Scenario of Vitamin D Status During Pregnancy in North Indian Population

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Abstract

Purpose of the Study

The aim of the study was to determine the prevalence and risk factor for vitamin D deficiency in our pregnant population.

Method

A total of 418 healthy primigravida with single live pregnancy and sure of dates attending the antenatal clinic between October 2011 and April 2013 were recruited. Women were excluded if they had history of current or past chronic medical disease. Women were also excluded if they had history of medication with drugs interfering with calcium and vitamin D metabolism.

Results

The prevalence of vitamin D deficiency during pregnancy has been found to be 391 (93.5 %). Severe vitamin D deficiency among pregnant patients was 34.44 % (144/418). The levels of serum 25(OH)D and serum calcium were significantly lower in severe deficient group than the adequate group [7.10 ± 1.49 vs. 38.90 ± 4.22 ng/ml (p = 0.001) and 7.13 ± 1.41 vs. 9.39 ± 0.88 ng/ml (p = 0.001)], respectively. Maternal education, husband education, socioeconomic status, serum calcium, serum phosphorous, and season were significant factors associated with vitamin D deficiency. Significant independent variables for severe vitamin D deficiency were low serum calcium, serum alkaline phosphatase, and serum phosphorus (OR 39.41, 95 % CI 10.30–150.85, p < 0.01), (OR 18.03, 95 % CI 3.95–82.44, p < 0.01), and (OR 8.40, 95 % CI 2.47–28.61, p < 0.01).

Conclusion

Vitamin D deficiency is highly prevalent among pregnant women in Northern India, and these raises concern about the health consequences for the mother and the offspring.

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Acknowledgments

This study was funded and supported by Maulana Azad Medical College, New Delhi, India.

Compliance with ethical requirements and Conflict of interest

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments. Authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India

    Sheetal Sharma (Ph.D Scholar), Ashok Kumar (Director Professor) & Sudha Prasad (Director Professor)

  2. Institute of Cytology and Preventive Oncology (ICPO), ICMR, Sector -39, Noida, 201301, Uttar Pradesh, India

    Shashi Sharma (Scientist ‘E’)

  3. 13B, DDA Flats, Ber Sarai, New Delhi, 110016, India

    Ashok Kumar (Director Professor)

Authors
  1. Sheetal Sharma
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  2. Ashok Kumar
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  3. Sudha Prasad
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  4. Shashi Sharma
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Corresponding author

Correspondence to Ashok Kumar.

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Sharma, S., Kumar, A., Prasad, S. et al. Current Scenario of Vitamin D Status During Pregnancy in North Indian Population. J Obstet Gynecol India 66, 93–100 (2016). https://doi.org/10.1007/s13224-014-0658-5

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  • DOI: https://doi.org/10.1007/s13224-014-0658-5

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