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From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases

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Abstract

Metabolic diseases have been a major public health issue and a clinical challenge worldwide. Dysfunction of metabolic homeostasis is linked to the onset of various diseases because the various metabolizing organs synchronously interact to maintain metabolic homeostasis. Therefore, understanding inter-organ communication is important to develop more accurate drug testing and discovery for the treatment of metabolic diseases. The physiologically relevant organ-on-a-chip system is an emerging technology to study metabolic dynamics by providing an organ-level platform. This review summarizes the single- and multi-organ chip systems to study metabolic diseases and their dynamics, focusing on their inter-organ crosstalk.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (2021R1C1C2005684 and 2021R1A2B5B02086828).

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Authors and Affiliations

  1. Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea

    Minjeong Jang & Hong Nam Kim

  2. Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea

    Hong Nam Kim

  3. School of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea

    Hong Nam Kim

  4. Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, 03722, Republic of Korea

    Hong Nam Kim

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Jang, M., Kim, H.N. From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases. BioChip J 17, 133–146 (2023). https://doi.org/10.1007/s13206-023-00098-z

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