Abstract
From boon molecules to molecules contributing to rising concern has been the sojourn of antibiotics. The problem of antibiotic contamination has gotten worse due to antibiotics’ pervasive use in every aspect of the environment. One such consequence of pollution is the increase in infections with antibiotic resistance. All known antimicrobials being used for human benefit lead to their repetitive and routine release into the environment. The misuse of antibiotics has aggravated the situation to a level that we are short of antibiotics to treat infections as organisms have developed resistance against them. Overconsumption is not just limited to human health care, but also occurs in other areas such as aquaculture, livestock, and veterinary applications for the purpose of improving feed and meat products. Due to their harmful effects on non-target species, the trace level of antibiotics in the aquatic ecosystem presents a significant problem. Since the introduction of antibiotics into the environment is more than their removal, they have been given the status of persistent pollutants. The buildup of antibiotics in the environment threatens aquatic life and may lead to bacterial strains developing resistance. As newer organisms are becoming resistant, there exists a shortage of antibiotics to treat infections. This has presented a very critical problem for the health-care community. Another rising concern is that the development of newer drug molecules as antibiotics is minimal. This review article critically explains the cause and nature of the pollution and the effects of this emerging trend. Also, in the latter sections, why we need newer antibiotics is questioned and discussed.
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References
Aga DS, Lenczewski M, Snow D et al (2016) Challenges in the measurement of antibiotics and in evaluating their impacts in agroecosystems: a critical review. J Environ Qual 45:407–419. https://doi.org/10.2134/JEQ2015.07.0393
Akiba M, Senba H, Otagiri H et al (2015) Impact of wastewater from different sources on the prevalence of antimicrobial-resistant Escherichia coli in sewage treatment plants in South India. Ecotoxicol Environ Saf 115:203–208. https://doi.org/10.1016/J.ECOENV.2015.02.018
Al-Ahmad A, Daschner FD (1999) Kümmerer K (1999) Biodegradability of Cefotiam, Ciprofloxacin, Meropenem, Penicillin G, and Sulfamethoxazole and Inhibition of Waste Water Bacteria. Archiv Environ Contamin Toxicol 37:158–163. https://doi.org/10.1007/S002449900501
Andersson DI (2014) Hughes D (2014) Microbiological effects of sublethal levels of antibiotics. Nat Rev Microbiol 12:465–478. https://doi.org/10.1038/nrmicro3270
Andreozzi R, Caprio V, Ciniglia C et al (2004) Antibiotics in the environment: occurrence in Italian STPs, fate, and preliminary assessment on algal toxicity of amoxicillin. Environ Sci Technol 38:6832–6838. https://doi.org/10.1021/ES049509A/SUPPL_FILE/ES049509ASI20040324_101936.PDF
Arnum PV (2013) The Weaknesses and Strengths of the Global API Market. PTSM: Pharmaceutical Technology Sourcing and Management 9. https://www.pharmtech.com/view/weaknesses-and-strengths-global-api-market. Accessed 10 Nov 2023
Arshad M, Mahmood SF, Khan M, Hasan R (2020) Covid -19, misinformation, and antimicrobial resistance. BMJ. https://doi.org/10.1136/BMJ.M4501
Azam M, Jan AT, Haq QMR (2016) blaCTX-M-152, a Novel Variant of CTX-M-group-25, Identified in a Study Performed on the Prevalence of Multidrug Resistance among Natural Inhabitants of River Yamuna. India Front Microbiol 7:176. https://doi.org/10.3389/FMICB.2016.00176/BIBTEX
Baile CA, McLaughlin CL, Chalupa WV, Snyder DL, Pendlum LC, Potter EL (1982) Effects of Monensin Fed to Replacement Dairy Heifers During the Growing and Gestation Period upon Growth, Reproduction, and Subsequent Lactation. J Dairy Sci 65(10):1941–1944. https://doi.org/10.3168/JDS.S0022-0302(82)82442-9
Bay DC, Rommens KL, Turner RJ (2008) Small multidrug resistance proteins: A multidrug transporter family that continues to grow. Biochimica Et Biophysica Acta (BBA) Biomembranes 1778:1814–1838. https://doi.org/10.1016/J.BBAMEM.2007.08.015
Beceiro A, Tomás M, Bou G (2013) Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev 26:185–230. https://doi.org/10.1128/CMR.00059-12
Bengtsson-Palme J, Larsson DGJ (2016) Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environ Int 86:140–149. https://doi.org/10.1016/J.ENVINT.2015.10.015
Bergeret P (2017) The future of food and agriculture: trends and challenges [ Note de lecture ]. 3
Bhattacharyya D, Banerjee J, Bandyopadhyay S, et al (2016) First Report on Vancomycin-Resistant Staphylococcus aureus in Bovine and Caprine Milk. https://home.liebertpub.com/mdr 22:675–681. https://doi.org/10.1089/MDR.2015.0330. Accessed 30 May 2023
Bischoff A, Meier C, Roth F (1977) Gentamicin neurotoxicity (polyneuropathy–encephalopathy). Schweiz Med Wochenschr 107:3–8
Blair JMA, Richmond GE, Piddock LJV (2014) Multidrug efflux pumps in gram-negative bacteria and their role in antibiotic resistance. Fut Microbiol 9:1165–1177. https://doi.org/10.2217/FMB.14.66
Bombaywala S, Mandpe A, Paliya S, Kumar S (2021) Antibiotic resistance in the environment: a critical insight on its occurrence, fate, and eco-toxicity. Environ Sci Pollut Res 28:24889–24916. https://doi.org/10.1007/S11356-021-13143-X
Bordeleau E, Stogios PJ, Evdokimova E et al (2021) ApmA is a unique aminoglycoside antibiotic acetyltransferase that inactivates apramycin. Mbio 12:1–11. https://doi.org/10.1128/MBIO.02705-20/SUPPL_FILE/MBIO.02705-20-SF008.PDF
Brandt KK, Amézquita A, Backhaus T et al (2015) Ecotoxicological assessment of antibiotics: A call for improved consideration of microorganisms. Environ Int 85:189–205. https://doi.org/10.1016/J.ENVINT.2015.09.013
Brown NG, Pennington JM, Huang W et al (2010) Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases. J Mol Biol 404:832–846. https://doi.org/10.1016/J.JMB.2010.10.008
Burhenne J, Ludwig M, Nikoloudis P, Spiteller M (1997) Primary photoproducts and half-lives. Environ Sci Pollut Res 4:10–15. https://doi.org/10.1007/BF02986257
Cardoso O, Porcher JM, Sanchez W (2014) Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: Review of evidence and need for knowledge. Chemosphere 115:20–30. https://doi.org/10.1016/J.CHEMOSPHERE.2014.02.004
Carusso S, Juárez AB, Moretton J, Magdaleno A (2018) Effects of three veterinary antibiotics and their binary mixtures on two green alga species. Chemosphere 194:821–827. https://doi.org/10.1016/J.CHEMOSPHERE.2017.12.047
Carvalho IT, Santos L (2016) Antibiotics in the aquatic environments: A review of the European scenario. Environ Int 94:736–757. https://doi.org/10.1016/J.ENVINT.2016.06.025
CDC (2019) Antibiotic resistance threats in the United States, U.S. Department of Health and Human Services, CDC, Atlanta, GA 2019
Center for Disease Dynamics, Economics & Policy (2015) State of the World’s Antibiotics, 2015. CDDEP, Washington, D.C
Chambers HF (2005) Community-Associated MRSA — Resistance and Virulence Converge. N Engl J Med 352:1485–1487. https://doi.org/10.1056/NEJME058023
Chattopadhyay MK, Zurek L, Nosanchuk JD (2014) Use of antibiotics as feed additives: a burning question. Front Microbiol. https://doi.org/10.3389/fmicb.2014.00334
Christou A, Antoniou C, Christodoulou C et al (2016) Stress-related phenomena and detoxification mechanisms induced by common pharmaceuticals in alfalfa (Medicago sativa L.) plants. Sci Total Environ 557:652–664. https://doi.org/10.1016/J.SCITOTENV.2016.03.054
Collu F, Cascella M (2013) Multidrug resistance and efflux pumps: insights from molecular dynamics simulations. Curr Top Med Chem 13:3165–3183. https://doi.org/10.2174/15680266113136660224
Deak D, Outterson K, Powers JH, Kesselheim AS (2016) Progress in the fight against multidrug-resistant bacteria? A review of U.S. food and drug administration-approved antibiotics, 2010–2015. Ann Intern Med 165:363–372. https://doi.org/10.7326/M16-0291
Douglas MW, Mulholland K, Denyer V, Gottlieb T (2001) Multi-drug resistant Pseudomonas aeruginosa outbreak in a burns unit — an infection control study. Burns 27:131–135. https://doi.org/10.1016/S0305-4179(00)00084-X
Du L, Liu W (2012) Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A Review. Agron Sustain Dev 32:309–327. https://doi.org/10.1007/S13593-011-0062-9/TABLES/5
Eady EA, Cove JH (2003) Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus–an emerging problem for the management of skin and soft tissue infections. Curr Opin Infect Dis 16:103–124. https://doi.org/10.1097/00001432-200304000-00007
Egorov AM, Ulyashova MM, Rubtsova MY (2018) Bacterial Enzymes and Antibiotic Resistance. Acta Naturae 10:33. https://doi.org/10.32607/20758251-2018-10-4-33-48
Feßler AT, Wang Y, Wu C, Schwarz S (2018) Mobile lincosamide resistance genes in Staphylococci. Plasmid 99:22–31. https://doi.org/10.1016/J.PLASMID.2018.06.002
Fiers WD, Craighead M, Singh I (2017) Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery. ACS Infect Dis 3:688–690. https://doi.org/10.1021/ACSINFECDIS.7B00108/ASSET/IMAGES/LARGE/ID-2017-001088_0002.JPEG
File TM (2004) Streptococcus pneumoniae and community-acquired pneumonia: A cause for concern. Am J Med Suppl 117:39–50. https://doi.org/10.1016/J.AMJMED.2004.07.007
File TM (2006) Clinical implications and treatment of multiresistant Streptococcus pneumoniae pneumonia. Clin Microbiol Infect 12:31–41. https://doi.org/10.1111/J.1469-0691.2006.01395.X
Frade VMF, Dias M, Teixeira ACSC, Palma MSA (2014) Environmental contamination by fluoroquinolones. Braz J Pharm Sci 50:41–54. https://doi.org/10.1590/S1984-82502011000100004
Fridkin SK, Hageman JC, Morrison M et al (2005) Methicillin-Resistant Staphylococcus aureus Disease in Three Communities. N Engl J Med 352:1436–1444. https://doi.org/10.1056/NEJMOA043252/SUPPL_FILE/1436SA1.PDF
Froehlich HE, Runge CA, Gentry RR et al (2018) Comparative terrestrial feed and land use of an aquaculture-dominant world. Proc Natl Acad Sci USA 115:5295–5300. https://doi.org/10.1073/PNAS.1801692115/SUPPL_FILE/PNAS.1801692115.SAPP.PDF
Gandra S, Joshi J, Trett A, Sankhil Lamkang A (2017) Suggested citation. Scoping Report on Antimicrobial Resistance in India
García-Fernández A, Dionisi AM, Arena S et al (2018) Human campylobacteriosis in Italy: Emergence of multi-drug resistance to ciprofloxacin, tetracycline, and erythromycin. Front Microbiol 9:1906. https://doi.org/10.3389/FMICB.2018.01906/BIBTEX
Gartiser S, Urich E, Alexy R, Kümmerer K (2007) Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes. Chemosphere 66:1839–1848. https://doi.org/10.1016/J.CHEMOSPHERE.2006.08.040
Gordon KA, Biedenbach DJ, Jones RN (2003) Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY antimicrobial surveillance program. Diagn Microbiol Infect Dis 46:285–289. https://doi.org/10.1016/S0732-8893(03)00087-7
Granich RM, Oh P, Lewis B et al (2005) Multidrug Resistance Among Persons With Tuberculosis in California, 1994–2003. JAMA 293:2732–2739. https://doi.org/10.1001/JAMA.293.22.2732
Grant GR, Lederman JA, Brandstetter RD (1997) T.G. Heaton, tuberculosis, and artificial pneumothorax: Once again, back to the future? Chest 112:7–8. https://doi.org/10.1378/chest.112.1.7
Grenni P, Ancona V, Barra Caracciolo A (2018) Ecological effects of antibiotics on natural ecosystems: A review. Microchem J 136:25–39. https://doi.org/10.1016/J.MICROC.2017.02.006
Grill MF, Maganti R (2008) Cephalosporin-induced neurotoxicity: Clinical manifestations, potential pathogenic mechanisms, and the role of electroencephalographs monitoring. Ann Pharmacother 42:1843–1850. https://doi.org/10.1345/aph.1L307
Grill MF, Maganti RK (2011) Neurotoxic effects associated with antibiotic use: management considerations. Br J Clin Pharmacol 72:381. https://doi.org/10.1111/J.1365-2125.2011.03991.X
Guo RX, Chen JQ (2012) Phytoplankton toxicity of the antibiotic chlortetracycline and its UV light degradation products. Chemosphere 87:1254–1259. https://doi.org/10.1016/J.CHEMOSPHERE.2012.01.031
Guo X, Yan Z, Zhang Y et al (2018) Behavior of antibiotic resistance genes under extremely high-level antibiotic selection pressures in pharmaceutical wastewater treatment plants. Sci Total Environ 612:119–128. https://doi.org/10.1016/J.SCITOTENV.2017.08.229
Hakko E, Mete B, Ozaras R et al (2005) Levofloxacin-induced delirium. Clin Neurol Neurosurg 107:158–159. https://doi.org/10.1016/J.CLINEURO.2004.05.006
Hamscher G, Mohring SAI (2012) Übersichtsbeitrag. Chem Ing Tec 7:1052–1061. https://doi.org/10.1002/CITE.201100255
Hay M, Thomas DW, Craighead JL et al (2014) Clinical development success rates for investigational drugs. Nat Biotechnol 32:40–51. https://doi.org/10.1038/NBT.2786
Heianza Y, Ma W, Li X et al (2020) Duration and Life-Stage of Antibiotic Use and Risks of All-Cause and Cause-Specific Mortality: Prospective Cohort Study. Circ Res 126:364–373. https://doi.org/10.1161/CIRCRESAHA.119.315279
Hsu J (2020) How covid-19 is accelerating the threat of antimicrobial resistance. BMJ. https://doi.org/10.1136/BMJ.M1983
Huber MM, Göbel A, Joss A et al (2005) Oxidation of pharmaceuticals during ozonation of municipal wastewater effluents: A pilot study. Environ Sci Technol 39:4290–4299. https://doi.org/10.1021/ES048396S/ASSET/IMAGES/LARGE/ES048396SF00009.JPEG
Hyde TB, Gay K, Stephens DS et al (2001) Macrolide Resistance Among Invasive Streptococcus pneumoniae Isolates. JAMA 286:1857–1862. https://doi.org/10.1001/JAMA.286.15.1857
Jang HM, Kim YB, Choi S et al (2018) Prevalence of antibiotic resistance genes from effluent of coastal aquaculture, South Korea. Environ Pollut 233:1049–1057. https://doi.org/10.1016/J.ENVPOL.2017.10.006
Jayalakshmi K, Paramasivam M, Sasikala M, Sumithra A (2017) Review on antibiotic residues in animal products and its impact on environments and human health. J Entomol Zool Studies 5:1446–1451
Jechalke S, Heuer H, Siemens J et al (2014) Fate and effects of veterinary antibiotics in soil. Trends Microbiol 22:536–545. https://doi.org/10.1016/J.TIM.2014.05.005
Jones D, Metzger HJ, Schatz A, Waksman SA (1944) Control of gram-negative bacteria in experimental animals by streptomycin. Science 100:103–105. https://doi.org/10.1126/SCIENCE.100.2588.103
Justice SS, Hunstad DA, Cegelski L, Hultgren SJ (2008) Morphological plasticity as a bacterial survival strategy. Nat Rev Microbiol 6:162–168. https://doi.org/10.1038/nrmicro1820
Katz L, Baltz RH (2016) Natural product discovery: past, present, and future. J Ind Microbiol Biotechnol 43:155–176. https://doi.org/10.1007/S10295-015-1723-5
Kaushik P, Anjay KS et al (2014) Isolation and prevalence of salmonella from chicken meat and cattle milk collected from local markets of Patna, India. Vet World 7:62–65. https://doi.org/10.14202/VETWORLD.2014.62-65
Kays MB, Smith DW, Wack MF, Denys GA (2002) Levofloxacin Treatment Failure in a Patient with Fluoroquinolone-Resistant Streptococcus pneumoniae Pneumonia. Pharmacother J Hum Pharmacol Drug Ther 22:395–399. https://doi.org/10.1592/PHCO.22.5.395.33185
Kazakova SV, Hageman JC, Matava M et al (2005) A Clone of Methicillin-Resistant Staphylococcus aureus among Professional Football Players. N Engl J Med 352:468–475. https://doi.org/10.1056/NEJMOA042859
Keeney KM, Yurist-Doutsch S, Arrieta MC, Finlay BB (2014) Effects of Antibiotics on Human Microbiota and Subsequent Disease. Annu Rev Microbiol 68:217–235. https://doi.org/10.1146/ANNUREV-MICRO-091313-103456
Khan GA, Berglund B, Khan KM et al (2013) Occurrence and Abundance of Antibiotics and Resistance Genes in Rivers, Canal and near Drug Formulation Facilities—A Study in Pakistan. PLoS ONE 8:e62712. https://doi.org/10.1371/JOURNAL.PONE.0062712
Kiangkitiwan B, Doppalapudi A, Fonder M et al (2008) Levofloxacin-induced delirium with psychotic features. Gen Hosp Psychiatry 30:381–383. https://doi.org/10.1016/J.GENHOSPPSYCH.2007.11.003
Kir A, Tahaoǧlu K, Okur E, Hatipoǧlu T (1997) Role of surgery in multi-drug-resistant tuberculosis: results of 27 cases. Eur J Cardiothorac Surg 12:531–534. https://doi.org/10.1016/S1010-7940(97)00230-3
Klein EY, Schueller E, Tseng KK et al (2020) The Impact of Influenza Vaccination on Antibiotic Use in the United States, 2010–2017. Open Forum Infect Dis. https://doi.org/10.1093/OFID/OFAA223
Klein EY, Van Boeckel TP, Martinez EM et al (2018a) Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A 115:E3463–E3470
Kourtesi C, Ball AR, Huang Y-Y et al (2013) Suppl 1: Microbial Efflux Systems and Inhibitors: Approaches to Drug Discovery and the Challenge of Clinical Implementation. Open Microbiol J 7:34. https://doi.org/10.2174/1874285801307010034
Kristiansson E, Fick J, Janzon A et al (2011) Pyrosequencing of Antibiotic-Contaminated River Sediments Reveals High Levels of Resistance and Gene Transfer Elements. PLoS ONE 6:e17038. https://doi.org/10.1371/JOURNAL.PONE.0017038
Kumar A, Schweizer HP (2005) Bacterial resistance to antibiotics: Active efflux and reduced uptake. Adv Drug Deliv Rev 57:1486–1513. https://doi.org/10.1016/J.ADDR.2005.04.004
Kumar M, Jaiswal S, Sodhi KK et al (2019) Antibiotics bioremediation: Perspectives on its ecotoxicity and resistance. Environ Int 124:448–461. https://doi.org/10.1016/J.ENVINT.2018.12.065
Kumar S, Mukherjee MM, Varela MF (2013) Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily. Int J Bacteriol 2013:1–15. https://doi.org/10.1155/2013/204141
Kümmerer K (2009) Antibiotics in the aquatic environment – A review – Part I. Chemosphere 75:417–434. https://doi.org/10.1016/J.CHEMOSPHERE.2008.11.086
Kuppusamy S, Kakarla D, Venkateswarlu K et al (2018) Veterinary antibiotics (VAs) contamination as a global agro-ecological issue: A critical view. Agric Ecosyst Environ 257:47–59. https://doi.org/10.1016/J.AGEE.2018.01.026
Kuroda T, Tsuchiya T (2009) Multidrug efflux transporters in the MATE family. Biochimica Et Biophysica Acta (BBA)-Proteins Proteom 1794:763–768. https://doi.org/10.1016/J.BBAPAP.2008.11.012
Kushner JM, Peckman HJ, Snyder CR (2001) Seizures associated with fluoroquinolones. Ann Pharmacother 35:1194–1198. https://doi.org/10.1345/aph.10359
Lambert PA (2002) Cellular impermeability and uptake of biocides and antibiotics in Gram-positive bacteria and mycobacteria. J Appl Microbiol 92:46S-54S. https://doi.org/10.1046/J.1365-2672.92.5S1.7.X
Lamoth F, Erard V, Asner S et al (2009) High imipenem blood concentrations associated with toxic encephalopathy in a patient with mild renal dysfunction. Int J Antimicrob Agents 34:386–388. https://doi.org/10.1016/J.IJANTIMICAG.2009.06.001
Larramendy ML, Soloneski S, Larramendy ML, Soloneski S (2015) Emerging pollutants in the environment-current and further implications. Emerg Pollutants Environ-Curr Further Implications. https://doi.org/10.5772/59332
Larsson DGJ (2014) Pollution from drug manufacturing: Review and perspectives. Philos Transact R Soc b: Biol Sci. https://doi.org/10.1098/RSTB.2013.0571
Larsson DGJ, Flach CF (2021) Antibiotic resistance in the environment. Nat Rev Microbiol 20:257–269. https://doi.org/10.1038/s41579-021-00649-x
Lee L, Savage VM, Yeh PJ (2018) Intermediate Levels of Antibiotics May Increase Diversity of Colony Size Phenotype in Bacteria. Comput Struct Biotechnol J 16:307–315. https://doi.org/10.1016/J.CSBJ.2018.08.004
Lessa FC, Mu Y, Bamberg WM et al (2015) Burden of Clostridium difficile Infection in the United States. N Engl J Med 372:825–834. https://doi.org/10.1056/NEJMOA1408913
Levin AS, Barone AA, Penço J et al (1999) Intravenous Colistin as Therapy for Nosocomial Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Clin Infect Dis 28:1008–1011. https://doi.org/10.1086/514732
Levison ME, Levison JH (2009) Pharmacokinetics and Pharmacodynamics of Antibacterial Agents. Infect Dis Clin North Am 23:791–815. https://doi.org/10.1016/j.idc.2009.06.008
Lewis K (2013) Platforms for antibiotic discovery. Nat Rev Drug Discovery 12:371–387. https://doi.org/10.1038/nrd3975
Li B, Zhang T (2010) Biodegradation and adsorption of antibiotics in the activated sludge process. Environ Sci Technol 44:3468–3473. https://doi.org/10.1021/ES903490H/SUPPL_FILE/ES903490H_SI_001.PDF
Lillenberg M, Litvin SV, Nei L et al (2010) Enrofloxacin and ciprofloxacin uptake by plants from soil. Agron Res 8:807–814
Lin AYC, Tsai YT (2009) Occurrence of pharmaceuticals in Taiwan’s surface waters: Impact of waste streams from hospitals and pharmaceutical production facilities. Sci Total Environ 407:3793–3802. https://doi.org/10.1016/J.SCITOTENV.2009.03.009
Ling LL, Schneider T, Peoples AJ et al (2015) A new antibiotic kills pathogens without detectable resistance. Nature 517:455–459. https://doi.org/10.1038/nature14098
Li Q, Pellegrino J, Lee DJ et al (2020) Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature 586:145–150. https://doi.org/10.1038/s41586-020-2761-3
Liu CG, Green SI, Min L et al (2020) Phage-antibiotic synergy is driven by a unique combination of antibacterial mechanism of action and stoichiometry. Mbio 11:1–19. https://doi.org/10.1128/MBIO.01462-20/SUPPL_FILE/MBIO.01462-20-SF005.TIF
Liu F, Ying GG, Tao R et al (2009) Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environ Pollut 157:1636–1642. https://doi.org/10.1016/J.ENVPOL.2008.12.021
Liu Y, Wang F, Chen X et al (2015) Cellular responses and biodegradation of amoxicillin in Microcystis aeruginosa at different nitrogen levels. Ecotoxicol Environ Saf 111:138–145. https://doi.org/10.1016/J.ECOENV.2014.10.011
Liu YY, Wang Y, Walsh TR et al (2016) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16:161–168. https://doi.org/10.1016/S1473-3099(15)00424-7
Li Z, Cao Y, Yi L et al (2019) Emergent Polymyxin Resistance: End of an Era? Open Forum Infect Dis. https://doi.org/10.1093/OFID/OFZ368
Lubelski J, Konings WN, Driessen AJM (2007) Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria. Microbiol Mol Biol Rev 71:463–476. https://doi.org/10.1128/MMBR.00001-07/ASSET/98294B98-F500-4BDD-8A00-B3890B9E967E/ASSETS/GRAPHIC/ZMR0030721590003.JPEG
Luepke KH, Suda KJ, Boucher H et al (2017) Past, Present, and Future of Antibacterial Economics: Increasing Bacterial Resistance, Limited Antibiotic Pipeline, and Societal Implications. Pharmacotherapy 37:71–84. https://doi.org/10.1002/PHAR.1868
Lyddiard D, Jones GL, Greatrex BW (2016) Keeping it simple: lessons from the golden era of antibiotic discovery. FEMS Microbiol Lett 363:84. https://doi.org/10.1093/FEMSLE/FNW084
Maia PP, da Silva EC, Rath S, Reyes FGR (2009) Residue content of oxytetracycline applied on tomatoes grown in open field and greenhouse. Food Control 20:11–16. https://doi.org/10.1016/J.FOODCONT.2008.01.007
Mann A, Nehra K, Rana JS, Dahiya T (2021) Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance. Curr Res Microb Sci 2:100030. https://doi.org/10.1016/J.CRMICR.2021.100030
Marathe NP, Gaikwad SS, Vaishampayan AA et al (2016) Mossambicus tilapia (Oreochromis mossambicus) collected from water bodies impacted by urban waste carries extended-spectrum beta-lactamases and integron-bearing gut bacteria. J Biosci 41:341–346. https://doi.org/10.1007/S12038-016-9620-2/FIGURES/2
Marathe NP, Regina VR, Walujkar SA et al (2013) A Treatment Plant Receiving Waste Water from Multiple Bulk Drug Manufacturers Is a Reservoir for Highly Multi-Drug Resistant Integron-Bearing Bacteria. PLoS ONE 8:e77310. https://doi.org/10.1371/JOURNAL.PONE.0077310
Marshall BM, Levy SB (2011) Food animals and antimicrobials: Impacts on human health. Clin Microbiol Rev 24:718–733. https://doi.org/10.1128/CMR.00002-11
Marsoni M, De Mattia F, Labra M et al (2014) Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants. Ecotoxicol Environ Saf 108:52–57. https://doi.org/10.1016/J.ECOENV.2014.05.029
Marx C, Mühlbauer V, Schubert S et al (2015) Representative input load of antibiotics to WWTPs: Predictive accuracy and determination of a required sampling quantity. Water Res 76:19–32. https://doi.org/10.1016/J.WATRES.2015.02.049
McDonald LC (2006) Trends in Antimicrobial Resistance in Health Care-Associated Pathogens and Effect on Treatment. Clin Infect Dis 42:S65–S71. https://doi.org/10.1086/499404
McGowan JE (2006) Resistance in nonfermenting gram-negative bacteria: Multidrug resistance to the maximum. Am J Infect Control 34:S29–S37. https://doi.org/10.1016/J.AJIC.2006.05.226
McManus PS, Stockwell VO, Sundin GW, Jones AL (2002) Antibiotic use in plant agriculture. Annu Rev Phytopathol 40:443–465. https://doi.org/10.1146/ANNUREV.PHYTO.40.120301.093927
Menard D, Dondorp A (2017) Antimalarial Drug Resistance: A Threat to Malaria Elimination. Cold Spring Harb Perspect Med 7:a025619. https://doi.org/10.1101/CSHPERSPECT.A025619
Miller LG, Perdreau-Remington F, Rieg G et al (2005) Necrotizing Fasciitis Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus in Los Angeles. N Engl J Med 352:1445–1453. https://doi.org/10.1056/NEJMOA042683
Miller WR, Munita JM, Arias CA (2014) Mechanisms of antibiotic resistance in enterococci. Expert Rev Anti-Infective Ther 12:1221–1236. https://doi.org/10.1586/14787210.2014.956092
Mirza SH, Beeching NJ, Hart CA (1996) Multi-drug resistant typhoid: A global problem. J Med Microbiol 44:317–319. https://doi.org/10.1099/00222615-44-5-317/CITE/REFWORKS
Mohr KI (2016) History of Antibiotics Research. Curr Top Microbiol Immunol 398:237–272. https://doi.org/10.1007/82_2016_499
Moloney MG (2016) Natural Products as a Source for Novel Antibiotics. Trends Pharmacol Sci 37:689–701. https://doi.org/10.1016/J.TIPS.2016.05.001
Moran GJ, Amii RN, Abrahamian FM, Talan DA (2005) Methicillin-resistant Staphylococcus aureus in Community-acquired Skin Infections. Emerg Infect Dis 11:928. https://doi.org/10.3201/EID1106.040641
Moran GJ, Krishnadasan A, Gorwitz RJ et al (2006) Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department. N Engl J Med 355:666–674. https://doi.org/10.1056/NEJMOA055356
Nachega JB, Chaisson RE (2003) Tuberculosis Drug Resistance: A Global Threat. Clin Infect Dis 36:S24–S30. https://doi.org/10.1086/344657
Naik VK, Shakya S, Patyal A et al (2015) Isolation and molecular characterization of Salmonella spp. from chevon and chicken meat collected from different districts of Chhattisgarh, India. Vet World 8:702. https://doi.org/10.1420/VETWORLD.2015.702-706
Nettleman MD (2005) Multidrug-Resistant Tuberculosis: News From the Front. JAMA 293:2788–2790. https://doi.org/10.1001/JAMA.293.22.2788
Nichols D, Cahoon N, Trakhtenberg EM et al (2010) Use of ichip for high-throughput in situ cultivation of “uncultivable microbial species.” Appl Environ Microbiol 76:2445–2450. https://doi.org/10.1128/AEM.01754-09/ASSET/E834948C-1F80-490D-B7D3-ABA0397D5ABE/ASSETS/GRAPHIC/ZAM9991008580004.JPEG
Nordmann P, Poirel L, Walsh TR, Livermore DM (2011) The emerging NDM carbapenemases. Trends Microbiol 19:588–595. https://doi.org/10.1016/J.TIM.2011.09.005
Nori P, Cowman K, Chen V et al (2021) Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge. Infect Control Hosp Epidemiol 42:84–88. https://doi.org/10.1017/ICE.2020.368
O’Neill J (2016) Tackling drug-resistant infections globally: final report and recommendations
Opris O, Copaciu F, Loredana Soran M et al (2013) Influence of nine antibiotics on key secondary metabolites and physiological characteristics in Triticum aestivum: Leaf volatiles as a promising new tool to assess toxicity. Ecotoxicol Environ Saf 87:70–79. https://doi.org/10.1016/J.ECOENV.2012.09.019
Paterson DL (2006) The Epidemiological Profile of Infections with Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter Species. Clin Infect Dis 43:S43–S48. https://doi.org/10.1086/504476
Paterson GK, Harrison EM, Holmes MA (2014) The emergence of mecC methicillin-resistant Staphylococcus aureus. Trends Microbiol 22:42–47. https://doi.org/10.1016/J.TIM.2013.11.003
Phillips PJ, Smith SG, Kolpin DW et al (2010) Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents. Environ Sci Technol 44:4910–4916. https://doi.org/10.1021/ES100356F/SUPPL_FILE/ES100356F_SI_001.PDF
Pino MR, Muñiz S, Val J, Navarro E (2016) Phytotoxicity of 15 common pharmaceuticals on the germination of Lactuca sativa and photosynthesis of Chlamydomonas reinhardtii. Environ Sci Pollut Res 23:22530–22541. https://doi.org/10.1007/S11356-016-7446-Y/TABLES/2
Polianciuc SI, Gurzău AE, Kiss B et al (2020) Antibiotics in the environment: causes and consequences. Med Pharm Rep 93:231. https://doi.org/10.15386/MPR-1742
Ramirez J, Guarner F, Bustos Fernandez L et al (2020) Antibiotics as major disruptors of gut microbiota. Front Cell Infect Microbiol. https://doi.org/10.3389/FCIMB.2020.572912
Redgrave LS, Sutton SB, Webber MA, Piddock LJV (2014) Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success. Trends Microbiol 22:438–445. https://doi.org/10.1016/J.TIM.2014.04.007
Reverter M, Sarter S, Caruso D et al (2020) Aquaculture at the crossroads of global warming and antimicrobial resistance. Nat Commun 11:1–8. https://doi.org/10.1038/s41467-020-15735-6
Rhomberg PR, Fritsche TR, Sader HS, Jones RN (2006) Clonal occurrences of multidrug-resistant Gram-negative bacilli: report from the Meropenem Yearly Susceptibility Test Information Collection Surveillance Program in the United States (2004). Diagn Microbiol Infect Dis 54:249–257. https://doi.org/10.1016/J.DIAGMICROBIO.2005.10.010
Roe MT, Pillai SD (2003) Monitoring and identifying antibiotic resistance mechanisms in bacteria. Poult Sci 82:622–626. https://doi.org/10.1093/PS/82.4.622
Rouquette-Loughlin C, Dunham SA, Kuhn M et al (2003) The NorM efflux pump of Neisseria gonorrhoeae and Neisseria meningitidis recognizes antimicrobial cationic compounds. J Bacteriol 185:1101–1106. https://doi.org/10.1128/JB.185.3.1101-1106.2003/ASSET/96CCE6FF-C099-46B9-BEEB-65FEB2884809/ASSETS/GRAPHIC/JB0330838003.JPEG
Samuelsen OB, Lunestad BT, Ervik A, Fjelde S (1994) Stability of antibacterial agents in an artificial marine aquaculture sediment studied under laboratory conditions. Aquaculture 126:283–290. https://doi.org/10.1016/0044-8486(94)90044-2
Sattler CA, Mason EO, Kaplan SL (2002) Prospective comparison of risk factors and demographic and clinical characteristics of community-acquired, methicillin-resistant versus methicillin-susceptible Staphylococcus aureus infection in children. Pediatr Infect Dis J 21:910–916. https://doi.org/10.1097/00006454-200210000-00005
Saxer G, Doebeli M, Travisano M (2010) The Repeatability of Adaptive Radiation During Long-Term Experimental Evolution of Escherichia coli in a Multiple Nutrient Environment. PLoS ONE 5:e14184. https://doi.org/10.1371/JOURNAL.PONE.0014184
Schar D, Sommanustweechai A, Laxminarayan R, Tangcharoensathien V (2018) Surveillance of antimicrobial consumption in animal production sectors of low- and middle-income countries: Optimizing use and addressing antimicrobial resistance. PLoS Med 15:e1002521. https://doi.org/10.1371/JOURNAL.PMED.1002521
Schlüsener MP, Bester K (2006) Persistence of antibiotics such as macrolides, tiamulin and salinomycin in soil. Environ Pollut 143:565–571. https://doi.org/10.1016/J.ENVPOL.2005.10.049
Sharma L, Siedlewicz G, Pazdro K (2021) The Toxic Effects of Antibiotics on Freshwater and Marine Photosynthetic Microorganisms: State of the Art. Plants 10:1–15. https://doi.org/10.3390/PLANTS10030591
Singer AC, Shaw H, Rhodes V, Hart A (2016) Review of antimicrobial resistance in the environment and its relevance to environmental regulators. Front Microbiol 7:1728. https://doi.org/10.3389/FMICB.2016.01728/BIBTEX
Sim WJ, Lee JW, Lee ES et al (2011) Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures. Chemosphere 82:179–186. https://doi.org/10.1016/J.CHEMOSPHERE.2010.10.026
Skariyachan S, Mahajanakatti AB, Grandhi NJ et al (2015) Environmental monitoring of bacterial contamination and antibiotic resistance patterns of the fecal coliforms isolated from Cauvery River, a major drinking water source in Karnataka, India. Environ Monit Assess 187:1–13. https://doi.org/10.1007/S10661-015-4488-4/FIGURES/6
Sodhi KK, Kumar M, Balan B et al (2021) Perspectives on the antibiotic contamination, resistance, metabolomics, and systemic remediation. SN Appl Sci 3:1–25. https://doi.org/10.1007/S42452-020-04003-3/FIGURES/2
Spellberg B, Guidos R, Gilbert D et al (2008) The epidemic of antibiotic-resistant infections: A call to action for the medical community from the infectious diseases society of America. Clin Infect Dis 46:155–164. https://doi.org/10.1086/524891/2/46-2-155-FIG002.GIF
Springmann M, Godfray HCJ, Rayner M, Scarborough P (2016) Analysis and valuation of the health and climate change cobenefits of dietary change. Proc Natl Acad Sci U S A 113:4146–4151. https://doi.org/10.1073/PNAS.1523119113/SUPPL_FILE/PNAS.1523119113.SAPP.PDF
Stockwell VO, Duffy B (2012) Use of antibiotics in plant agriculture. Rev Sci Tech 31:199–210. https://doi.org/10.20506/RST.31.1.2104
Sudha S, Mridula C, Silvester R, Hatha AAM (2014) Prevalence and antibiotic resistance of pathogenic Vibrios in shellfishes from Cochin market. Indian J Geo-Marine Sci 43:815–824
Su H, Liu S, Hu X et al (2017) Occurrence and temporal variation of antibiotic resistance genes (ARGs) in shrimp aquaculture: ARGs dissemination from farming source to reared organisms. Sci Total Environ 607–608:357–366. https://doi.org/10.1016/J.SCITOTENV.2017.07.040
Sui Q, Huang J, Deng S et al (2010) Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. Water Res 44:417–426. https://doi.org/10.1016/J.WATRES.2009.07.010
Sun C, Dudley S, Trumble J, Gan J (2018) Pharmaceutical and personal care products-induced stress symptoms and detoxification mechanisms in cucumber plants. Environ Pollut 234:39–47. https://doi.org/10.1016/J.ENVPOL.2017.11.041
Sung SW, Kang CH, Kim YT et al (1999) Surgery increased the chance of cure in multi-drug resistant pulmonary tuberculosis. Eur J Cardiothorac Surg 16:187–193. https://doi.org/10.1016/S1010-7940(99)00158-X
Szychowski J, Kondo J, Zahr O et al (2011) Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2″-Ether Analogues. ChemMedChem 6:1961. https://doi.org/10.1002/CMDC.201100346
Thai PK, Ky LX, Binh VN et al (2018) Occurrence of antibiotic residues and antibiotic-resistant bacteria in effluents of pharmaceutical manufacturers and other sources around Hanoi, Vietnam. Sci Total Environ 645:393–400. https://doi.org/10.1016/J.SCITOTENV.2018.07.126
Thilsted SH, Thorne-Lyman A, Webb P et al (2016) Sustaining healthy diets: The role of capture fisheries and aquaculture for improving nutrition in the post-2015 era. Food Policy 61:126–131. https://doi.org/10.1016/J.FOODPOL.2016.02.005
Thiolas A, Bornet C, Davin-Régli A et al (2004) Resistance to imipenem, cefepime, and cefpirome associated with mutation in Omp36 osmoporin of Enterobacter aerogenes. Biochem Biophys Res Commun 317:851–856. https://doi.org/10.1016/J.BBRC.2004.03.130
Thomas RJ (1994) Neurotoxicity of antibacterial therapy. South Med J 87:869–874. https://doi.org/10.1097/00007611-199409000-00001
Timmerer U, Lehmann L, Schnug E, Bloem E (2020) Toxic Effects of Single Antibiotics and Antibiotics in Combination on Germination and Growth of Sinapis alba L. Plants 9:107. https://doi.org/10.3390/PLANTS9010107
Van Acker H, Van Dijck P, Coenye T (2014) Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms. Trends Microbiol 22:326–333. https://doi.org/10.1016/J.TIM.2014.02.001
Van Boeckel TP, Brower C, Gilbert M et al (2015a) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci USA 112:5649–5654. https://doi.org/10.1073/PNAS.1503141112
Vedantam G, Guay GG, Austria NE et al (1998) Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli. Antimicrob Agents Chemother 42:88–93. https://doi.org/10.1128/AAC.42.1.88/ASSET/01CBDE71-6151-4A2C-B7FB-E2ACC87E4D99/ASSETS/GRAPHIC/AC0180370002.JPEG
Vezzulli L, Grande C, Reid PC et al (2016) Climate influence on Vibrio and associated human diseases during the past half-century in the coastal North Atlantic. Proc Natl Acad Sci USA 113:E5062–E5071. https://doi.org/10.1073/PNAS.1609157113/SUPPL_FILE/PNAS.201609157SI.PDF
Voigt M, Jaeger M (2017) On the photodegradation of azithromycin, erythromycin and tylosin and their transformation products—a kinetic study. Sustain Chem Pharm 5:131–140. https://doi.org/10.1016/J.SCP.2016.12.001
Wang X, Ryu D, Houtkooper RH, Auwerx J (2015) Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment. BioEssays 37:1045–1053. https://doi.org/10.1002/BIES.201500071
Wang M, Shen W, Yan L et al (2017) Stepwise impact of urban wastewater treatment on the bacterial community structure, antibiotic contents, and prevalence of antimicrobial resistance. Environ Pollut 231:1578–1585. https://doi.org/10.1016/J.ENVPOL.2017.09.055
Watanabe I, Hodges GR, Dworzack DL et al (1978) Neurotoxicity of intrathecal gentamicin: A case report and experimental study. Ann Neurol 4:564–572. https://doi.org/10.1002/ANA.410040618
Wegener HC (2012) A15 Antibiotic resistance—linking human and animal health. In: Institute of Medicine (US). Improving Food Safety through a One Health Approach: Workshop Summary. National Academies Press, Washington, DC, USA, pp 331–349)
Wohde M, Berkner S, Junker T et al (2016) Occurrence and transformation of veterinary pharmaceuticals and biocides in manure: a literature review. Environ Sci Eur 28:1–25. https://doi.org/10.1186/S12302-016-0091-8/FIGURES/1
Wright GD (2014) Something old, something new: Revisiting natural products in Antibiotic drug discovery. Can J Microbiol 60:147–154. https://doi.org/10.1139/CJM-2014-0063/ASSET/IMAGES/LARGE/CJM-2014-0063F1.JPEG
Yang L, Feng YX, Zhang H, Yu XZ (2021) Estimating the synergistic and antagonistic effects of dual antibiotics on plants through root elongation test. Ecotoxicology 30:1598–1609. https://doi.org/10.1007/S10646-020-02308-Y/FIGURES/4
Yang SJ, Kreiswirth BN, Sakoulas G et al (2009) Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureus. J Infect Dis 200:1916–1920. https://doi.org/10.1086/648473
Yerushalmi H, Lebendiker M, Schuldiner S (1995) EmrE, an Escherichia coli 12-kDa Multidrug Transporter, Exchanges Toxic Cations and H+ and Is Soluble in Organic Solvents. J Biol Chem 270:6856–6863. https://doi.org/10.1074/JBC.270.12.6856
Zazueta-Beltran J, Muro-Amador S, Flores-Gaxiola A et al (2007) High rates of multidrug-resistant Mycobacterium tuberculosis in Sinaloa State, Mexico. J Infect 54:411–412. https://doi.org/10.1016/j.jinf.2006.03.035
Zhang T, Li B (2011) Occurrence, Transformation, and Fate of Antibiotics in Municipal Wastewater Treatment Plants. Crit Rev Environ Sci Technol 41:951–998. https://doi.org/10.1080/10643380903392692
Zhu XQ, Wang XM, Li H et al (2017) Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. J Antimicrob Chemother 72:993–997. https://doi.org/10.1093/JAC/DKW549
Zignol M, Hosseini MS, Wright A et al (2006) Global Incidence of Multidrug-Resistant Tuberculosis. J Infect Dis 194:479–485. https://doi.org/10.1086/505877
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The authors acknowledge the Indian Institute of Technology Guwahati, Assam, India, for providing research fellowship and infrastructural resources for carrying out the present work.
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The authors acknowledge the Indo-EU Horizon 2020 project (BT/IN/EU-WR/60/SP/2018) funded by the Department of Biotechnology, New Delhi, for providing financial support.
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Gangar, T., Patra, S. Antibiotic persistence and its impact on the environment. 3 Biotech 13, 401 (2023). https://doi.org/10.1007/s13205-023-03806-6
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DOI: https://doi.org/10.1007/s13205-023-03806-6