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Natural protein-based electrospun nanofibers for advanced healthcare applications: progress and challenges

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Abstract

Electrospinning is an electrostatic fiber fabrication technique that operates by the application of a strong electric field on polymer solution or melts. It is used to fabricate fibers whose size lies in the range of few microns to the nanometer range. Historic development of electrospinning has evinced attention due to its outstanding attributes such as small diameter, excellent pore inter-connectivity, high porosity, and high surface-to-volume ratio. This review aims to highlight the theory behind electrospinning and the machine setup with a detailed discussion about the processing parameters. It discusses the latest innovations in natural protein-based electrospun nanofibers for health care applications. Various plant- and animal-based proteins have been discussed with detailed sample preparation and corresponding processing parameters. The usage of these electrospun nanofibers in regenerative medicine and drug delivery has also been discussed. Some technical innovations in electrospinning techniques such as emulsion electrospinning and coaxial electrospinning have been highlighted. Coaxial electrospun core–shell nanofibers have the potential to be utilized as an advanced nano-architecture for sustained release targeted delivery as well as for regenerative medicine. Healthcare applications of nanofibers formed via emulsion and coaxial electrospinning have been discussed briefly. Electrospun nanofibers have still much scope for commercialization on large scale. Some of the available wound-dressing materials have been discussed in brief.

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Acknowledgements

The authors acknowledge the support provided under the DST-FIST Grant No.SR/FST/PS-I/2018/48 of Government of India.

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  1. Department of Chemistry, Biochemistry and Forensic Science, Amity School of Applied Sciences, Amity University Haryana, Gurugram, 122413, India

    Anushka Agarwal, Gyaneshwar K. Rao, Sudip Majumder, Manish Shandilya, Varun Rawat & Chandra Mohan Srivastava

  2. Department of Applied Chemistry, Delhi Technological University, New Delhi, Delhi, 110042, India

    Roli Purwar

  3. Department of Environmental Engineering, University of Seoul, Seoul, 130743, South Korea

    Monu Verma

  4. Centre for Polymer Technology, Amity School of Applied Sciences, Amity University Haryana, Gurugram, 122413, India

    Chandra Mohan Srivastava

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  1. Anushka Agarwal
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Agarwal, A., Rao, G.K., Majumder, S. et al. Natural protein-based electrospun nanofibers for advanced healthcare applications: progress and challenges. 3 Biotech 12, 92 (2022). https://doi.org/10.1007/s13205-022-03152-z

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