Skip to main content
SpringerLink
Log in

Evaluation of Multiparametric Magnetic Resonance Imaging and Correlation with Radical Prostatectomy Histopathology Specimen in Prostate Cancer

  • Original Article
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract  

Magnetic resonance imaging (MRI) has shown a great potential in the evaluation and management of prostate cancer. In this study, we would like to evaluate the benefit of multiparametric MRI in the detection and localization of prostate cancer by comparing it with the gold standard of histopathology from radical prostatectomy. In this single-centre prospective study, 90 consecutive patients underwent radical prostatectomy from November 2016 to May 2018. All patients first underwent multiparametric (mp)-MRI, and all suspicious regions of interest were delineated and recorded on a 5-point scale as defined in prostate imaging reporting and data system version 2 (PI-RADS V2) score. All radical prostatectomy specimens, acquired after robotic radical prostatectomy with extended pelvic lymphadenectomy, were sent for histopathological examination (HPE). The mean age of the 90 patients was 65.3 years, and the mean serum prostate-specific antigen (PSA) was 16.9 ng/ml. The sensitivity and specificity of mp-MRI in the detection of the corresponding region of interest (ROI) on HPE were 67.4% and 89.3% respectively. Positive predictive value (PPV), negative predictive value (NPV), and accuracy of mp-MRI in the detection of corresponding ROI on HPE were 86.3%, 73.3%, and 78.3% respectively. The mp-MRI detected 96.8% solitary lesions and 61.7% multifocal lesions on the corresponding ROI on HPE. Multiparametric MRI has an excellent specificity and reasonable sensitivity for the diagnosis of prostate cancer. It is a good modality for the detection of solitary tumours, higher-grade tumours, detection of seminal vesicle invasion and extracapsular extension and helps in the decision-making process before radical prostatectomy, focal therapy or selecting an appropriate candidate for active surveillance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References 

  1. Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64:9

    Article  PubMed  Google Scholar 

  2. Guneyli S, Erdem CZ, Erdem LO (2016) Magnetic resonance imaging of prostate cancer. Clin Imaging 40:601–609

    Article  PubMed  Google Scholar 

  3. Barentsz JO, Richenberg J, Clements R, Choyke P, Verma S, Villeirs G et al (2012) ESUR Prostate MR Guidelines 2012. Eur Radiol 22(4):746–757

    Article  PubMed  PubMed Central  Google Scholar 

  4. Le JD, Tan N, Shkolyar E, Lu DY, Kwan L, Marks LS et al (2015) Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology. Eur Urol 67:569–576

    Article  PubMed  Google Scholar 

  5. Sarkar D (2016) The role of multi-parametric MRI and fusion biopsy for the diagnosis of prostate cancer – a systematic review. J Pros Canc 1:2

    Google Scholar 

  6. Jesse DL, Nelly T, Eugene S, David YL, Lorna K, Leonard SM et al (2015) Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology. Eur Urol 67:569–576

    Article  Google Scholar 

  7. Moosavi B, Flood TA, Al-Dandan O, Breau RH, Cagiannos I, Morash C et al (2016) Multiparametric MRI of the anterior prostate gland: clinical-radiological-histopathological Correlation. Clin Radiol 71:405–417

    Article  CAS  PubMed  Google Scholar 

  8. Ghai S, Haider MA (2015) Multiparametric-MRI in diagnosis of prostate cancer. Indian J Urol 31(3):194–201

    Article  PubMed  PubMed Central  Google Scholar 

  9. Turkbey B, Mani H, Shah V, Rastinehad AR, Bernardo M, Pohida T et al (2011) Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds. J Urol 186:1818–1824

    Article  PubMed  PubMed Central  Google Scholar 

  10. Turkbey B, Albert PS, Kurdziel K, Choyke PL (2009) Imaging localized prostate cancer: current approaches and new developments. AJR Am J Roentgenol 192:1471

    Article  PubMed  PubMed Central  Google Scholar 

  11. Roethke MC, Kuru TH, Schultze S, Tichy D, Fenchel M, Schlemmer HP et al (2014) Evaluation of the ESUR PI-RADS scoring system for multiparametric MRI of the prostate with targeted MR/TRUS fusion-guided biopsy at 3.0 Tesla. Eur Radiol 24:344–352

    Article  CAS  PubMed  Google Scholar 

  12. Thompson JE, Van LPJ, Moses D, Shnier R, Brenner P, Delprado W et al (2016) The diagnostic performance of multiparametric magnetic resonance imaging to detect significant prostate cancer. J Urol 195:1428–1435

    Article  CAS  PubMed  Google Scholar 

  13. Prostate Imaging Reporting and Data System (PI-RADS) [Internet] Reston (VA): American college of radiology; [cited 2015 Mar 5]. Available from: http://www.acr.org/Quality-Safety/Resources/PIRADS/

  14. Huang S, Mann S, O’Sullivan R, Ryan A, Landau A, Snow R et al (2016) Correlation between multiparametric MRI findings and radical prostatectomy specimens in 162 patients. J Urol 185(4s):e393

    Google Scholar 

  15. Loggitsi D, Gyftopoulos A, Economopoulos N, Apostolaki A, Kalogeropoulos T, Thanos A et al (2017) Multiparametric magnetic resonance imaging of the prostate for tumour detection and local staging: imaging in 1.5T and histopathologic correlation. Can Assoc Radiol J 68:379–386

    Article  PubMed  Google Scholar 

  16. Peuch P, Potiron E, Lemaitre L, Leroy X, Haber GP, Crouzet S et al (2009) Dynamic contrast-enhanced-magnetic resonance imaging evaluation of intraprostatic prostate cancer: correlation with radical prostatectomy specimens. J Urol 74(5):1094–1099

    Article  Google Scholar 

  17. Grivas N, Hinnenb K, Jongc JD, Heemsbergend W, Moonend L, Witteveen T et al (2018) Seminal vesicle invasion on multi-parametric magnetic resonance imaging: correlation with histopathology. Eur J Radiol 98:107–112

    Article  PubMed  Google Scholar 

  18. De Rooij M, Hamoen EH, Witjes JA, Barentsz JO, Rovers MM (2016) Accuracy of magnetic resonance imaging for local staging of prostate cancer: a diagnostic meta-analysis. Eur Urol 70:233

    Article  PubMed  Google Scholar 

  19. Hövels AM, Heesakkers RA, Adang EM, Jager GJ, Strum S, Hoogeveen YL et al (2008) The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol 63:387

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. SMVS Swaminarayan Hospital, Gandhinagar, Gujarat, India

    Rakesh Kumar Vadher

  2. Department of Urology and Renal Transplant, SMS Medical College, Jaipur, India

    Somendra Bansal

  3. Artemis Hospitals, Gurugram, India

    Rajiv Yadav

  4. Kidney and Urology Institute, Medanta-The Medicity, Gurugram, India

    Narmada P. Gupta

  5. Radiology and Imaging, Medanta-The Medicity, Gurugram, India

    Kulbir Ahlawat

Authors
  1. Rakesh Kumar Vadher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Somendra Bansal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rajiv Yadav
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Narmada P. Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kulbir Ahlawat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Somendra Bansal.

Ethics declarations

Conflict of Interest                                                                                                                        

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vadher, R.K., Bansal, S., Yadav, R. et al. Evaluation of Multiparametric Magnetic Resonance Imaging and Correlation with Radical Prostatectomy Histopathology Specimen in Prostate Cancer. Indian J Surg Oncol 14, 603–608 (2023). https://doi.org/10.1007/s13193-023-01733-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-023-01733-9

Keywords

Search

Navigation