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Granular Cell Tumor of Breast: a Case Report and Review of Literature

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

This is an article reporting a case of granular cell tumor in the left breast in a 58 year old lady. Patient presented with a 3 × 3 cm mass in the left breast. Mammography reported a BIRADS 5 lesion in the left breast. With a clinical and radiological diagnosis of malignancy, patient was sent for FNAC (Fine needle aspiration Cytology). The cytology report was granular cell tumor. Following this patient underwent wide excision of the mass. Histopathology confirmed the cytological diagnosis of granular cell tumor of the breast. Patient is on regular follow up and is presently free of disease. The case report is followed up by a brief review of literature of granular cell tumor of the breast.

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References

  1. Abrikossoff A (1926) Uber Myome, ausgehend von der quergestreiften wilkuerlichen muskulatur. Virchows Arch Pathol Anat 260:215–233

    Article  Google Scholar 

  2. Aoyama et al. (2012) Granular cell tumors: a report of six cases. World J Surg Oncol 10:204

    Article  PubMed  PubMed Central  Google Scholar 

  3. Dhillon AP, Rode J (1983) Immunohistochemical studies of S100 protein and other neural characteristics expressed by granular cell tumour. Diagn Histopathol 6(1):23–28

    CAS  PubMed  Google Scholar 

  4. Lifshitz MS, Flotte TJ, Greco MA (1984) Congenital granular cell epulis. Immunohistochemical and ultrastructural observations. Cancer 53(9):1845–1848

    Article  CAS  PubMed  Google Scholar 

  5. Schrader KA, Nelson TN, De Luca A, Huntsman DG. McGillivray BC (2009) Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. Clin Genet 75 (2): 185–189

    Article  CAS  PubMed  Google Scholar 

  6. Adeniran A, Al-Ahmadie H, Mahoney MC, Robinson-Smith TM (2004) Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J 10(6):528–531

    Article  PubMed  Google Scholar 

  7. Vance SF, Hudson RP (1969) Granular cell myoblastoma. Am J Pathol 52:208–211

    Google Scholar 

  8. Patel A, Lefemine V, Yousuf SM, Abou-Samra W (2008) Granular cell tumor of pectoral muscle mimicking breast cancer. Cases J 6:142

    Article  Google Scholar 

  9. Brown AC, Audisio RA, Regitnig P (2011) Granular cell tumour of the breast. Surg Oncol 20:97–105

    Article  PubMed  Google Scholar 

  10. Kragel PJ, Fiorella RM, Kremer H (1995) Tumoral fibrosis and lack of circumscription in granular cell tumor of the breast. South Med J 88:1146–1148

    Article  CAS  PubMed  Google Scholar 

  11. Willen R, Willen H, Balldin G, Albrechtsson U (1984) Granular cell tumor of the mammary gland simulating malignancy. Virchows Arch [A] 403:391–400

    Article  CAS  Google Scholar 

  12. Vos LD, Tjon A, Vroegindweij D, Vrints LW (1994) Granular cell tumor of the breast: mammographic and histologic correlation. Eur J Radiol 19:56–59

    Article  CAS  PubMed  Google Scholar 

  13. Gibbons D, Leitch M, Coscia J, Lindberg G, Molberg K, Ashfaq R, Saboorian MH (2000) Fine niddle aspiration cytology and histologic findings of granular cell tumor of the breast: review of 19 cases with clinical/radiological correlation. Breast J 6:27–30

    Article  PubMed  Google Scholar 

  14. Papalas JA, Wylie JD, Dash RC (2011) Recurrence risk and margin status in granular cell tumors of the breast: a clinicopathologic study of 13 patients. Arch Pathol Lab Med 135(7):890–895

    PubMed  Google Scholar 

  15. Rosso R, Scelsi M, Carnevali L (2000) Granular cell traumatic neuroma: a lesion occurring in mastectomy scars. Arch Pathol Lab Med 124:709–711

    CAS  PubMed  Google Scholar 

  16. Kommoss F, Mercer L, Schmidt RA, Talerman A (1989) Granular cell tumor of the breast mimicking carcinoma in pregnancy. Obstet Gynecol 73:898–900

    CAS  PubMed  Google Scholar 

  17. Mithal KR, True LD (1988) Origin of granules in granular cell tumor. Intracellular myelin formation with autodigestion. Arch Pathol Lab Med 112:302–303

    Google Scholar 

  18. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG (1998) Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 22:779–794

    Article  CAS  PubMed  Google Scholar 

  19. Sonobe H, Iwata J, Furihata M, Moriki T, Ohtsuki Y (1998) Malignant granular cell tumor: report of a case and review and the literature. Pathol Res Pract 194:507–513

    Article  CAS  PubMed  Google Scholar 

  20. Kataoka A, Koike M, Kuranuki K, Wakayama K, Yamada S, Akasaka Y (2005) A case of malignant granular cell tumor arisen in the chest wall (in Japanese with English abstract). J Jpn Surg Assoc 66:2403–2406

    Article  Google Scholar 

  21. Khansur T, Balducci L, Tavassoli M (1987) Granular cell tumor. Clinical spectrum of the benign and malignant entity. Cancer 60:220–222

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India

    Bhargavan Rexeena, Augustine Paul, Ranjan Acharya Nitish & Cherian Kurian

  2. Department of Pathology, Regional Cancer Centre, Trivandrum, Kerala, India

    R. K. Anila

Authors
  1. Bhargavan Rexeena
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  2. Augustine Paul
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  3. Ranjan Acharya Nitish
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  4. Cherian Kurian
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  5. R. K. Anila
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Correspondence to Ranjan Acharya Nitish.

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Rexeena, B., Paul, A., Nitish, R.A. et al. Granular Cell Tumor of Breast: a Case Report and Review of Literature. Indian J Surg Oncol 6, 446–448 (2015). https://doi.org/10.1007/s13193-015-0455-3

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  • DOI: https://doi.org/10.1007/s13193-015-0455-3

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