Skip to main content

Advertisement

Log in

A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity

  • Case Report
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

The tumors of dendritic/reticulum cells constitutes the rarest tumors affecting the lymphoid tissues. Among them tumors derived from fibroblastic reticular cells (FBRCs) are very rare, and those of cytokeratin (CK)-positive interstitial reticulum cells (CIRCs) origin are even more rare. These tumors can be easily misdiagnosed as tumors of other dendritic cells, myofibroblastic tumors or even metastatic poorly differentiated carcinomas. Less than twenty such cases have been reported in the literature till date. We present such a rare case of CIRC sarcoma in cervical lymph node of a 64-year-old man.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Andriko JW, Kaldjian EP, Tsokos M, Abbondanzo SL, Jaffe ES (1998) Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. Am J Surg Pathol 22:1048–1058

    Article  CAS  PubMed  Google Scholar 

  2. Sundersingh S, Majhi U, Krishnamurthy A, Velusami SD (2013) Cytokeratin-positive interstitial reticulum cell sarcoma: extranodal presentations mimicking carcinoma. Indian J Pathol Microbiol 56:172–175

    Article  PubMed  Google Scholar 

  3. Dong YC, Wu B, Sheng Z, Wang JD, Zhou HB, Zhou XJ (2008) Cytokeratin-positive interstitial reticulum cell tumors of lymph nodes: a case report and review of literature. Chin Med J (Engl) 121:658–663

    Google Scholar 

  4. Chan AC, Serrano-Olmo J, Erlandson RA, Rosai J (2000) Cytokeratin-positive malignant tumors with reticulum cell morphology: a subtype of fibroblastic reticulum cell neoplasm? Am J Surg Pathol 24:107–116

    Article  CAS  PubMed  Google Scholar 

  5. Gould VE, Warren WH, Faber LP, Kuhn C, Franke WW (1990) Malignant cells of epithelial phenotype limited to thoracic lymph nodes. Eur J Cancer 26:1121–1126

    Article  CAS  PubMed  Google Scholar 

  6. Lucioni M, Boveri E, Rosso R, Benazzo M, Necchi V, Danova M, Incardona P, Franco C, Viglio A, Riboni R, Lazzarino M, Magrini U, Canevari A, Paulli M (2003) Lymph node reticulum cell neoplasm with progression into cytokeratin-positive interstitial reticulum cell (CIRC) sarcoma: a case study. Histopathology 43:583–591

    Article  CAS  PubMed  Google Scholar 

  7. Schuerfeld K, Lazzi S, De Santi MM, Gozzetti A, Leoncini L, Pileri SA (2003) Cytokeratin-positive interstitial cell neoplasm: a case report and classification issues. Histopathology 43:491–494

    Article  CAS  PubMed  Google Scholar 

  8. Kwon JE, Yang WI, Kim HK, Kwon KW, Kwon TJ, Choi EC, Lee KG (2009) Cytokeratin-positive interstitial reticulum cell sarcoma: a case report with cytological, immunohistochemical, and ultrastructural findings. Cytopathology 20:202–205

    Article  CAS  PubMed  Google Scholar 

  9. Martel M, Sarli D, Colecchia M, Coppa J, Romito R, Schiavo M, Mazzaferro V, Rosai J (2003) Fibroblastic reticular cell tumor of the spleen: report of a case and review of the entity. Hum Pathol 34:954–957

    Article  PubMed  Google Scholar 

  10. Jones D, Amin M, Ordonez NG, Glassman AB, Hayes KJ, Medeiros LJ (2001) Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. Mod Pathol 14:1059–1067

    Article  CAS  PubMed  Google Scholar 

  11. Kakiuchi C, Ishida T, Sato H, Katano H, Ishiko T, Mukai H, Kogi M, Kasuga N, Takeuchi K, Yamane K, Fukayama M, Mori S (2002) Secretion of interleukin-6 and vascular endothelial growth factor by spindle cell sarcoma complicating Castleman’s disease (so-called ‘vascular neoplasia’). J Pathol 197:264–271

    Article  PubMed  Google Scholar 

  12. Suárez D, Izquierdo FM, Méndez JR, Escobar J, Cabeza A, Junco P (2011) Tumor of fibroblastic reticular cells of lymph node coincidental with an undifferentiated endometrial stromal sarcoma. report of a case with distinctive immunophenotype and Kikuchi-like necro-inflammatory response. APMIS 119:216–220

    Article  PubMed  Google Scholar 

Download references

Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kaushik Saha.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roy, S., Das, I., Saha, K. et al. A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity. Indian J Surg Oncol 6, 271–275 (2015). https://doi.org/10.1007/s13193-015-0392-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-015-0392-1

Keywords

Navigation