Abstract
Introduction
3-Hydroxyphencyclidine (3-HO-PCP) is a new psychoactive substance (NPS) and a hydroxy derivative of phencyclidine (PCP), and N-ethylhexedrone (Hexen) is a synthetic cathinone. We describe an analytically confirmed case of acute toxicity related to the use of both 3-hydroxyphencyclidine and N-ethylhexedrone.
Case Report
A 56-year-old male was brought to the Emergency Department by ambulance with hyperthermia (39.9 °C), sinus tachycardia (150 beats per minute), reduced consciousness, ocular clonus, and vertical nystagmus. He was treated with cooled intravenous (IV) fluids and IV benzodiazepines. Following 1 hour of treatment, his temperature fell to 37.7 °C, he developed rhabdomyolysis (creatine kinase peaked at 5999 IU (normal range < 229 IU)): he was managed with supportive measures and was discharged after 25 hours. The patient admitted regular use of Hexen and recent use of 3-HO-PCP. Analysis of urine and serum identified 3-hydroxyphencyclidine and metabolites, N-ethylhexedrone and metabolites, and clephedrone and metabolites.
Discussion
This is a case of analytically confirmed toxicity to 3-HO-PCP and N-ethylhexedrone. The acute toxicity reported in this patient is consistent with the use of 3-HO-PCP, but there were sympathomimetic and serotonergic features potentially consistent with the cathinone N-ethylhexedrone. The description of the acute toxicity of NPS, such as these, is vital to aid medical toxicologists and emergency medicine physicians treating patients who use them.
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References
Johnson N, Itzhak Y, Pasternak GW. Interaction of two phencyclidine opiate-like derivatives with 3H-opioid binding sites. Eur J Pharmacol. 1984;101(3–4):281–4.
Morris H, Wallach J. From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs. Drug Test Anal. 2014;6(7–8):614–32.
Kamenka JM, Chiche B, Goudal R, Geneste P, Vignon J, Vincent JP, et al. Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl-piperidine derivatives). J Med Chem. 1982;25(4):431–5.
Suzuki T, Yamamoto T, Hori T, Baba A, Shiraishi H, Ito T, et al. Autoradiographic study on the pharmacological characteristics of [3H]3-OH-PCP binding sites in rat brain. Eur J Pharmacol. 1996;310(2–3):243–55.
Itzhak Y. High and low affinity psychotomimetic opioid binding sites: characterization by a novel 3H-PCP-analog. NIDA Res Monogr. 1986;75:173–6.
Blankaert P. FACT SHEET, N-ethylhexedrone Belgium: Belgian Early Warning System Drugs 2016. https://erowid.org/chemicals/ethylhexedrone/ethylhexedrone_info1.pdf. Accessed 08/02/2019.
Liu C, Jia W, Li T, Hua Z, Qian Z. Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl-alpha-EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, alpha-PiHP, 4-Cl-alpha-PHP, and 4-F-alpha-PHP. Drug Test Anal. 2017;9(8):1162–71.
Eshleman AJ, Nagarajan S, Wolfrum KM, Reed JF, Swanson TL, Nilsen A, et al. Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters. Psychopharmacology. 2018.
Tripsit. 3-HO-PCP: Tripsit 2019. http://drugs.tripsit.me/3-ho-pcp#summary. Accessed 08/02/2019.
Bey T, Patel A. Phencyclidine intoxication and adverse effects: a clinical and pharmacological review of an illicit drug. Cal J Emerg Med. 2007;8(1):9–14.
Laboratory NF. ANALYTICAL REPORT, N-ethylhexedrone (C14H21NO), 2-(ethylamino)-1-phenylhexan-1-one [Analytical Report]. Slovenia: National Forensic Laboratory; 2016 [updated 02/10/2016. https://www.policija.si/apps/nfl_response_web/0_Analytical_Reports_final/N-ethylhexedrone-ID-1503-16-report_final.pdf Accessed 08/02/2019.
Erowid Experience Vaults, 3-HO-PCP Reports: Erowid 2019. https://erowid.org/experiences/subs/exp_3HOPCP.shtml. Accessed 24/07/2019.
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Dunlop, L.C., Wood, D., Archer, J. et al. Severe Toxicity to the New Psychoactive Substances 3-Hydroxyphencyclidine and N-Ethylhexedrone: an Analytically Confirmed Case Report. J. Med. Toxicol. 16, 67–70 (2020). https://doi.org/10.1007/s13181-019-00734-x
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DOI: https://doi.org/10.1007/s13181-019-00734-x