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Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on 18F-FDG PET/CT

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Abstract

Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes 90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Metastases to axillary lymph nodes (ALN) are very rare. As per literature, only 25 cases have been reported. We report an unusual case of 47-year-old male with Hürthle cell carcinoma of the thyroid presenting with a solitary axillary lymph node metastasis 17 years after thyroidectomy, along with review of literature.

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References

  1. Sampson E, Brierley JD, Le LW, Rotstein L, Tshang RW. Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis. Cancer. 2007;110:1451–6.

    Article  PubMed  Google Scholar 

  2. Chiofalo MG, Losito NS, Fulciniti F, Setola SV, Tommaselli A, Marone U, et al. Axillary node metastasis from differentiated thyroid carcinoma with Hürthle and signet cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings. BMC Cancer. 2012;12:55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kamaleshwaran KK, Rajan F, Mohanan V, Shinto AS. Rare case of axillary lymph node metastasis in papillary thyroid carcinoma detected using Iodine-131 whole-body scintigraphy and single-photon emission computed tomography/computed tomography. Indian J Nucl Med. 2015;30:168–70.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Hafez MT, Refky B, Elwahab KA, Arafa M, Abdou I, Elnahas W. Axillary lymph nodes metastasis in a patient with recurrent papillary thyroid cancer: a case report. J Med Case Rep. 2015;9:181.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Singhal N, Chaturvedi P, Joshi P, Malik A. Axillary lymph node metastases in differentiated thyroid Cancer “an uncommon presentation with clinical implications”. Austin J Clin Case Rep. 2015;2:1065.

    Google Scholar 

  6. Cummings AL, Goldfard M. Thyroid carcinoma metastases to axillary lymph nodes: report of two rare cases of papillary and medullary thyroid carcinoma and literature review. Endocr Pract. 2014;20:e34–7.

    Article  PubMed  Google Scholar 

  7. Koo EJ, Lee MR. Axillary lymph node metastasis of papillary thyroid carcinoma: a case report. Clin Exp Thyroidol. 2014;7:194–200.

    Google Scholar 

  8. Machado NO, Chopra PJ, Raouf ZR, Khatib NJ, Sinnakirouchenan R. Axillary lymph node metastasis from thyroid malignancy. Unusual presentation with ominous implications. Br J Med Med Res. 2013;3:1634–5.

    Article  Google Scholar 

  9. Elboga U, Kalender E, Yilmaz M, Celen YZ, Aktolun C. Axillary lymph node metastasis of papillary thyroid carcinoma detected by FDG PET/CT in a thyroglobulin-positive patient with negative whole-body 131I scan. Clin Nucl Med. 2012;37:1120–2.

    Article  PubMed  Google Scholar 

  10. Damle N, Singh H, Soundararajan R, Bal CS, Sahoo M, Mathur S. Radioiodine avid axillary lymph node metastasis in papillary thyroid Cancer: report of a case. Indian J Surg Oncol. 2011;2:193–6.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Krishnamurthy A, Vaidhyanathan A. Axillary lymph node metastasis in papillary thyroid carcinoma: report of a case and review of the literature. J Cancer Res Ther. 2011;7:220–2.

    Article  PubMed  Google Scholar 

  12. Kepenekci I, Demirkan A, Cakmak A, Tug T, Ekinci C. Axillary lymph node metastasis as a late manifestation of papillary thyroid carcinoma. Thyroid. 2009;19:417–9.

    Article  PubMed  Google Scholar 

  13. Angeles-Angeles A, Chable-Montero F, Martinez-Benitez B, Albores-Saavedra J. Unusual metastases of papillary thyroid carcinoma: report of 2 cases. Ann Diagn Pathol. 2009;13:189–96.

    Article  PubMed  Google Scholar 

  14. Nakayama H, Wada N, Masudo Y, Rino Y. Axillary lymph node metastasis from papillary thyroid carcinoma - report of a case. Surg Today. 2007;37:311–5.

    Article  PubMed  Google Scholar 

  15. Ers V, Galant C, Malaise J, Rahier J, Daumerie C. Axillary lymph node metastasis in recurrence of papillary thyroid carcinoma. A case report. Wein Klin Wochenschr. 2006;118:124–7.

    Article  Google Scholar 

  16. Koike K, Fujii T, Yanaga H, Nakagawa S, Yokoyama G, Yahara T, et al. Axillary lymph node recurrence of papillary thyroid microcarcinoma: report of a case. Surg Today. 2004;34:440–3.

    Article  PubMed  Google Scholar 

  17. Shehadeh NJ, Vernick J, Lonardo F, Madan SK, Jacobs JR, Yoo GH, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature. Am J Otolaryngol. 2004;25:48–53.

    Article  PubMed  Google Scholar 

  18. Lal G, Ituarte P, Duh QY, Clark O (2003) The axilla as a rare site of metastatic thyroid cancer with ominous implications (abstract only). 74th Annual meeting of ATA.

  19. Minagawa A, Iitaka M, Suzuki M, Yasuda S, Kameyama K, Shimada S, et al. A case of primary mucoepidermoid carcinoma of the thyroid: molecular evidence of its origin. Clin Endocrinol. 2002;57:551–6.

    Article  Google Scholar 

  20. Chen SW, Bennett G, Price J. Axillary lymph node calcification due to metastatic papillary carcinoma. Australas Radiol. 1998;42:241–3.

    Article  CAS  PubMed  Google Scholar 

  21. Ueda S, Takahashi H, Akehi S, Nakata T, Satoh N, Kimura S. A case of recurrent thyroid cancer metastasizing to axillary lymph nodes 7 years after the initial thyroidectomy. J Japanese Pract Surg Soc. 1996;57:2934–7.

    Google Scholar 

  22. Mizukami Y, Nakajima H, Annen Y, Michigishi T, Nonomura A, Nakamura S. Mucin-producing poorly differentiated adenocarcinoma of the thyroid. A case. Pathol Res Pract. 1993;189:608–12.

    Article  CAS  PubMed  Google Scholar 

  23. Rouviere P. Anatomie des lymphatiques de l'homme. J Am Med Assoc. 1932;99:1716.

    Google Scholar 

  24. Kuffner HA, McCook BM, Swaminatha R, Myers EN, Hunt JL. Controversial ectopic thyroid: a case report of thyroid tissue in the axilla and benign total thyroidectomy. Thyroid. 2005;15:1095–7.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (East), AIIMS Campus, New Delhi, 110029, India

    Meghana Prabhu, Chandrasekhar Bal & Rakesh Kumar

  2. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Deepali Jain & Siddhartha Datta Gupta

Authors
  1. Meghana Prabhu
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  2. Deepali Jain
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  3. Siddhartha Datta Gupta
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  4. Chandrasekhar Bal
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  5. Rakesh Kumar
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Correspondence to Rakesh Kumar.

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Conflict of Interest

The authors Meghana Prabhu, Deepali Jain, Siddhartha Datta Gupta, Chandra Sekhar Bal, Rakesh Kumar declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Human and Animal Rights

This chapter does not contain any studies with animals performed by any of the authors.

Informed Consent

The institutional review board of our institute approved this retrospective study, and the requirement to obtain informed consent was waived.

Informed consent was obtained from the patient for FDG PET/CT in the study.

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Prabhu, M., Jain, D., Gupta, S.D. et al. Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on 18F-FDG PET/CT. Nucl Med Mol Imaging 52, 389–393 (2018). https://doi.org/10.1007/s13139-018-0539-4

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  • DOI: https://doi.org/10.1007/s13139-018-0539-4

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