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Longitudinal Decline of Striatal Subregional [18F]FP-CIT Uptake in Parkinson’s Disease

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Abstract

Purpose

Dopamine transporter imaging is suggested to be a useful imaging biomarker for Parkinson’s disease (PD) progression and monitoring drug effects. We investigated the longitudinal decline characteristics of striatal [18F]FP-CIT uptake in PD.

Methods

We retrospectively reviewed 35 PD patients and 9 non-PD patients. All patients underwent [18F]FP-CIT PET at the initial diagnosis and follow-up. PET images were spatially normalized and analyzed with eight striatal and one occipital VOI templates. We measured the specific to non-specific binding ratio (SNBR) of the striatal subregions and calculated the absolute annual reduction (AAR) and relative annual reduction (%RAR) of the SNBRs.

Results

Total striatal SNBRs in PD patients were significantly lower than those in non-PD patients, with the most significant difference in the posterior putamen. Both AAR (0.26 ± 0.14 vs. 0.09 ± 0.19, p < 0.05) and %RAR (6.9 ± 3.5 vs. 1.2 ± 2.7, p < 0.001) of total striatal SNBRs were significantly greater in PD than non-PD patients. There were no significant differences in the AAR and %RAR of total striatal SNBRs between elderly and young onset PD. The AARs of the posterior putamen were higher in early PD than in advanced PD. Conversely, the %RARs were not significantly different between early and more advanced PD. The disease duration was significantly negatively correlated with the AAR but not with the %RAR of the posterior putamen.

Conclusions

The longitudinal decline of striatal [18F]FP-CIT uptake in PD was nonlinear and significantly faster than that in non-PD, with a different rate of decline among the striatal subregions.

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References

  1. Fahn S. Does levodopa slow or hasten the rate of progression of Parkinson’s disease? J Neurol. 2005;252(Suppl 4):iv37–42.

    PubMed  Google Scholar 

  2. Oh M, Kim JS, Kim JY, Shin KH, Park SH, Kim HO, et al. Subregional patterns of preferential striatal dopamine transporter loss differ in Parkinson disease, progressive supranuclear palsy, and multiple-system atrophy. J Nucl Med. 2012;53:399–406.

    Article  CAS  PubMed  Google Scholar 

  3. Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 2002;287:1653–61.

    Article  Google Scholar 

  4. Seibyl JP, Marek K, Sheff K, Zoghbi S, Baldwin RM, Charney DS, et al. Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson’s patients. J Nucl Med. 1998;39:1500–8.

    CAS  PubMed  Google Scholar 

  5. Winogrodzka A, Bergmans P, Booij J, van Royen EA, Janssen AG, Wolters EC. [123I]FP-CIT SPECT is a useful method to monitor the rate of dopaminergic degeneration in early-stage Parkinson’s disease. J Neural Transm (Vienna). 2001;108:1011–9.

    Article  CAS  PubMed  Google Scholar 

  6. Marek K, Innis R, van Dyck C, Fussell B, Early M, Eberly S, et al. [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression. Neurology. 2001;57:2089–94.

    Article  CAS  PubMed  Google Scholar 

  7. Fearnley JM, Lees AJ. Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain. 1991;114(Pt 5):2283–301.

    Article  PubMed  Google Scholar 

  8. Brooks DJ, Salmon EP, Mathias CJ, Quinn N, Leenders KL, Bannister R, et al. The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson’s disease, studied with PET. Brain. 1990;113(Pt 5):1539–52.

    Article  PubMed  Google Scholar 

  9. Morrish PK, Sawle GV, Brooks DJ. An [18F]dopa-PET and clinical study of the rate of progression in Parkinson’s disease. Brain. 1996;119(Pt 2):585–91.

    Article  PubMed  Google Scholar 

  10. Vingerhoets FJ, Snow BJ, Lee CS, Schulzer M, Mak E, Calne DB. Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism. Ann Neurol. 1994;36:759–64.

    Article  CAS  PubMed  Google Scholar 

  11. Morrish PK, Rakshi JS, Bailey DL, Sawle GV, Brooks DJ. Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with [18F]dopa PET. J Neurol Neurosurg Psychiatry. 1998;64:314–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lee CS, Samii A, Sossi V, Ruth TJ, Schulzer M, Holden JE, et al. In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson’s disease. Ann Neurol. 2000;47:493–503.

    Article  CAS  PubMed  Google Scholar 

  13. Lee SJ, Oh SJ, Chi DY, Kang SH, Kil HS, Kim JS, et al. One-step high-radiochemical-yield synthesis of [18F]FP-CIT using a protic solvent system. Nucl Med Biol. 2007;34:345–51.

    Article  CAS  PubMed  Google Scholar 

  14. Park E, Hwang YM, Lee CN, Kim S, Oh SY, Kim YC, et al. Differential diagnosis of patients with inconclusive Parkinsonian features using [(18)F]FP-CIT PET/CT. Nucl Med Mol Imaging. 2014;48:106–13.

    Article  CAS  PubMed  Google Scholar 

  15. Foundation NP. Available from: http://www.parkinson.org/understanding-parkinsons/what-is-parkinsons/young-onset-parkinsons

  16. Kim HW, Kim JS, Oh M, Oh JS, Lee SJ, Oh SJ, et al. Different loss of dopamine transporter according to subtype of multiple system atrophy. Eur J Nucl Med Mol Imaging. 2016;43:517–25.

    Article  CAS  PubMed  Google Scholar 

  17. Kish SJ, Shannak K, Hornykiewicz O. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson’s disease. Pathophysiologic and clinical implications. N Engl J Med. 1988;318:876–80.

    Article  CAS  PubMed  Google Scholar 

  18. Brooks DJ, Ibanez V, Sawle GV, Quinn N, Lees AJ, Mathias CJ, et al. Differing patterns of striatal 18F-dopa uptake in Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. Ann Neurol. 1990;28:547–55.

    Article  CAS  PubMed  Google Scholar 

  19. Brooks DJ. Functional imaging in relation to parkinsonian syndromes. J Neurol Sci. 1993;115:1–17.

    Article  CAS  PubMed  Google Scholar 

  20. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci. 1973;20:415–55.

    Article  CAS  PubMed  Google Scholar 

  21. German DC, Manaye K, Smith WK, Woodward DJ, Saper CB. Midbrain dopaminergic cell loss in Parkinson’s disease: computer visualization. Ann Neurol. 1989;26:507–14.

    Article  CAS  PubMed  Google Scholar 

  22. Rinne JO, Rummukainen J, Paljarvi L, Rinne UK. Dementia in Parkinson’s disease is related to neuronal loss in the medial substantia nigra. Ann Neurol. 1989;26:47–50.

    Article  CAS  PubMed  Google Scholar 

  23. Nurmi E, Bergman J, Eskola O, Solin O, Vahlberg T, Sonninen P, et al. Progression of dopaminergic hypofunction in striatal subregions in Parkinson’s disease using [18F]CFT PET. Synapse. 2003;48:109–15.

    Article  CAS  PubMed  Google Scholar 

  24. Nurmi E, Ruottinen HM, Kaasinen V, Bergman J, Haaparanta M, Solin O, et al. Progression in Parkinson’s disease: a positron emission tomography study with a dopamine transporter ligand [18F]CFT. Ann Neurol. 2000;47:804–8.

    Article  CAS  PubMed  Google Scholar 

  25. Nurmi E, Bergman J, Eskola O, Solin O, Hinkka SM, Sonninen P, et al. Reproducibility and effect of levodopa on dopamine transporter function measurements: a [18F]CFT PET study. J Cereb Blood Flow Metab. 2000;20:1604–9.

    Article  CAS  PubMed  Google Scholar 

  26. Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, et al. Levodopa and the progression of Parkinson’s disease. N Engl J Med. 2004;351:2498–508.

    Article  CAS  PubMed  Google Scholar 

  27. Lee CS, Kim S-J, Oh SJ, Kim HO, Yun S-C, Doudet D, et al. Uneven age effects of [18F] FP-CIT binding in the striatum of Parkinson’s disease. Ann Nucl Med. 2014;28:874–9.

    Article  CAS  PubMed  Google Scholar 

  28. Selikhova M, Williams DR, Kempster PA, Holton JL, Revesz T, Lees AJ. A clinico-pathological study of subtypes in Parkinson’s disease. Brain. 2009;132(Pt 11):2947–57.

    Article  CAS  PubMed  Google Scholar 

  29. Gibb WR, Lees AJ. A comparison of clinical and pathological features of young- and old-onset Parkinson’s disease. Neurology. 1988;38:1402–6.

    Article  CAS  PubMed  Google Scholar 

  30. Staffen W, Mair A, Unterrainer J, Trinka E, Ladurner G. Measuring the progression of idiopathic Parkinson’s disease with [123I] beta-CIT SPECT. J Neural Transm (Vienna). 2000;107:543–52.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C2768).

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Authors and Affiliations

  1. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympicro 43-gil, Songpa-gu, Seoul, 05505, South Korea

    Changhwan Sung, Jungsu S. Oh, Minyoung Oh, Sang Ju Lee, Seung Jun Oh & Jae Seung Kim

  2. Department of Nuclear Medicine, Dankook University College of Medicine, Cheonan, South Korea

    Jai Hyuen Lee

  3. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Sun Ju Chung & Chong Sik Lee

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  1. Changhwan Sung
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Correspondence to Jae Seung Kim.

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Conflict of Interest

Changhwan Sung, Jai Hyuen Lee, Jungsu S Oh, Minyoung Oh, Sang Ju Lee, Seung Jun Oh, Sun Ju Chung, Chong Sik Lee, and Jae Seung Kim declare that they have no conflict of interest.

Ethical Approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by our Institutional Review Board (IRB no. S2016–2189-0001).

Informed Consent

The institutional review board of our institute approved this retrospective study, and the requirement to obtain informed consent was waived.

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Sung, C., Lee, J.H., Oh, J.S. et al. Longitudinal Decline of Striatal Subregional [18F]FP-CIT Uptake in Parkinson’s Disease. Nucl Med Mol Imaging 51, 304–313 (2017). https://doi.org/10.1007/s13139-017-0481-x

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  • DOI: https://doi.org/10.1007/s13139-017-0481-x

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