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Analysis of Cerebral Blood Flow with Single Photon Emission Computed Tomography in Mild Subcortical Ischemic Vascular Dementia

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Abstract

Purpose

The mechanism of cognitive dysfunction of subcortical ischemic vascular dementia (SIVaD) is not yet fully understood. The objective of this study was to investigate and compare the distribution of regional cerebral perfusion (CP) change in the mild forms of SIVaD, a relatively homogeneous subtype of vascular dementia, using statistical parametric mapping (SPM) analysis of the technetium-99m hexamethylproplyeneamineoxime (Tc-99m HMPAO) single photon emission computed tomography (SPECT).

Materials and Methods

A total of 28 patients with mild SIVaD and 33 healthy controls were prospectively recruited and underwent SPECT imaging studies between January 2012 and May 2013. SPECT was performed to measure the regional CP, and SPM was applied to the analysis of the SPECT data.

Results

The regional CP was significantly decreased in the bilateral insula, anterior and posterior cingulated gyrus, precentral gyrus, and subcallosal gyrus as well as the right inferior parietal lobule in the SIVaD patients compared to the controls (corrected p = 0.01). The pattern of CP abnormality correlated well with those previously reported in later forms of SIVaD.

Conclusions

Reduction of CP in the brain areas mentioned was present earlier on in the natural course of SIVaD pathophysiology. Our study suggests that cognitive dysfunction of SIVaD may be related to these regional CP deficits.

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Disclosure

Conflict of Interest

The authors Sonya Youngju Park, Hyukjin Yoon, Narae Lee, Jin Kyoung Oh, Ie Ryung Yoo, Sung Hoon Kim and Yong An Chung declare that they have no conflict of interest.

Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for inclusion in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.

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Authors and Affiliations

  1. Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seochogu Banpodong 505, 137-701, Seoul, South Korea

    Sonya Youngju Park, Hyukjin Yoon, Narae Lee, Ie Ryung Yoo & Sung Hoon Kim

  2. Department of Radiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 665 Bupyeong-dong, Bupyeong-gu, 403-720, Incheon, South Korea

    Jin Kyoung Oh & Yong An Chung

  3. Department of Nuclear Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seochogu Banpodong 505, 137-701, Seoul, South Korea

    Sonya Youngju Park

Authors
  1. Sonya Youngju Park
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  2. Hyukjin Yoon
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  3. Narae Lee
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  4. Jin Kyoung Oh
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  6. Sung Hoon Kim
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  7. Yong An Chung
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Correspondence to Yong An Chung.

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Park, S.Y., Yoon, H., Lee, N. et al. Analysis of Cerebral Blood Flow with Single Photon Emission Computed Tomography in Mild Subcortical Ischemic Vascular Dementia. Nucl Med Mol Imaging 48, 272–277 (2014). https://doi.org/10.1007/s13139-014-0287-z

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  • DOI: https://doi.org/10.1007/s13139-014-0287-z

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