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Cell source, differentiation, functional stimulation, and potential application of human thermogenic adipocytes in vitro

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An Erratum to this article was published on 05 October 2017

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Abstract

Recent investigations have showed that the functional thermogenic adipocytes are present in both infants and adult humans. Accumulating evidence suggests that the coexistence of classical and inducible brown (brite) adipocytes in humans at adulthood and these adipocytes function to generate heat from energy resulting in reducing body fat and improving glucose metabolism. Human thermogenic adipocytes can be differentiated in vitro from stem cells, cell lines, or adipose stromal vascular fraction. Pre-activated human brite adipocytes in vitro can maintain their thermogenic function in normal or obese immunodeficient mice; therefore, they improve glucose homeostasis and reduce fat mass in obese animals. These key findings have opened a new door to use in vitro thermogenic adipocytes as a cell therapy to prevent obesity and related disorders. Thus, this paper intends to highlight our knowledge in aspects of in vitro human brite/brown adipocytes for the further studies.

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Change history

  • 05 October 2017

    Volume 73 issue 3 was published with an incorrect cover date. Correct is August 2017. The Publisher apologizes for this mistake and all related inconveniences caused by this.

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Authors and Affiliations

  1. Institute for Research and Development, Duy Tan University, 03 Quang Trung, Da Nang, Vietnam

    Dinh-Toi Chu

  2. Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam

    Dinh-Toi Chu

  3. College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Vietnam

    Yang Tao

  4. VNU University of Science, Vietnam National University, Hanoi, Vietnam

    Le Hoang Son

  5. VINMEC Research Institute of Stem Cell and Gene Technology, Hanoi, Vietnam

    Duc-Hau Le

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  1. Dinh-Toi Chu
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  2. Yang Tao
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  4. Duc-Hau Le
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Correspondence to Dinh-Toi Chu.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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An erratum to this article is available at https://doi.org/10.1007/s13105-017-0593-x.

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Chu, DT., Tao, Y., Son, L.H. et al. Cell source, differentiation, functional stimulation, and potential application of human thermogenic adipocytes in vitro. J Physiol Biochem 73, 315–321 (2016). https://doi.org/10.1007/s13105-017-0567-z

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