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Lipodystrophies: adipose tissue disorders with severe metabolic implications

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Abstract

Lipodystrophy encompass a group of heterogeneous disorders consisting in marked reduction, absence, and/or the redistribution of adipose tissue. Lipodystrophy is frequently complicated with severe insulin resistance, diabetes, hyperlipidemia, and fatty liver. Anatomically, lipodystrophies can be partial or generalized. Etiologically, they can be congenital or acquired. Lipodystrophy diagnosis can be challenging, and it has been suggested that partial forms can be easily misdiagnosed as common central obesity with associated metabolic syndrome. Conventional insulin-sensitizing approaches usually fail to fully ameliorate insulin resistance in lipodystrophic patients. Leptin replacement is an approved therapy for the metabolic complications of congenital generalized lipodystrophy. Novel nutritional interventions are promising complementary approaches for treating lipodystrophy metabolic complications.

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  1. Department of Nutrition, Diabetes and Metabolism, Pontificia Universidad Católica de Chile, C/ Av. Libertador Bernardo O’Higgins 340, Santiago, Chile

    Víctor A. Cortés & Marta Fernández-Galilea

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  1. Víctor A. Cortés
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  2. Marta Fernández-Galilea
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Correspondence to Víctor A. Cortés.

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Cortés, V.A., Fernández-Galilea, M. Lipodystrophies: adipose tissue disorders with severe metabolic implications. J Physiol Biochem 71, 471–478 (2015). https://doi.org/10.1007/s13105-015-0404-1

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