Abstract
Precision medicine envisions a future of effective diagnosis, treatment, and prevention grounded in precise understandings of the genetic and environmental determinants of disease. Given that the original genome-wide association studies represented a predominately European White population, and that diversity in genomic studies must account for genetic variation both within and across racial categories, new research studies are at a heightened risk for inadequate representation. Currently biological samples are being made available for sequencing in biobanks across the USA, but the diversity of those samples is unknown. The aims of this study were to describe the types of recruitment and enrollment materials used by US biobanks and the diversity of the samples contained within their collection. Biobank websites and brochures were evaluated for reading level, health literacy, and factors known to encourage the recruitment of minorities, such as showing pictures of diverse populations. Biobank managers were surveyed by mail on the methods and materials used for enrollment, recruitment, consent, and the self-reported race/ethnicity of biobank participants. From 51 US biobanks (68% response rate), recruitment and enrollment materials were in English only, and most of the websites and brochures exceeded a fifth-grade reading level. When compared to the 2015 US Census, self-reported race/ethnicity of participants was not significantly different for Whites (61%) and blacks (13%). The percentages were significantly lower for Hispanics and Latinos (18 vs. 7%, p = 0.00) and Hawaiian/Pacific Islanders (0.2 vs. 0.01%; p = 0.01) and higher for Asians (13 vs. 5%, p = 0.01). Materials for recruitment predominantly in English may limit participation by underrepresented populations.
Similar content being viewed by others
References
Ashida S, Goodman M, Pandya C, Koehly LM, Lachance C, Stafford J, Kaphingst KA (2011) Age differences in genetic knowledge, health literacy and causal beliefs for health conditions. Public Health Genomics 14:307–316. doi:10.1159/000316234
Ashing-Giwa K, Rosales M (2012) Recruitment and retention strategies of African American and Latina American breast cancer survivors in a longitudinal psycho-oncology study. Oncol Nurs Forum 39:E434–E442. doi:10.1188/12.ONF.E434-E442
Bonham VL, Citrin T, Modell SM, Franklin TH, Bleicher EW, Fleck LM (2009) Community-based dialogue: engaging communities of color in the United States’ genetics policy conversation. J Health Polit Policy Law 34:325–359. doi:10.1215/03616878-2009-009
Bonham VL, Callier SL, Royal CD (2016) Will precision medicine move us beyond race? N Engl J Med 374:2003–2005. doi:10.1056/NEJMp1511294
Boyer GJ, Whipple W, Cadigan RJ, Henderson GE (2012) Biobanks in the United States: how to identify an undefined and rapidly evolving population. Biopreservation Biobanking 10:511–517. doi:10.1089/bio.2012.0034
Burkardt DD, Graham JM Jr, Short SS, Frykman PK (2014) Advances in Hirschsprung disease genetics and treatment strategies: an update for the primary care pediatrician. Clin Pediatr 53:71–81. doi:10.1177/0009922813500846
Bustamante CD, Burchard EG, De la Vega FM (2011) Genomics for the world. Nature 475:163–165. doi:10.1038/475163a
Cadigan RJ, Juengst E, Davis A, Henderson G (2014) Underutilization of specimens in biobanks: an ethical as well as a practical concern? Genet Med : Off J Am Coll Med Genet 16:738–740. doi:10.1038/gim.2014.38
Cohn EG, Husamudeen M, Larson EL, Williams JK (2014) Increasing participation in genomic research and biobanking through community-based capacity building. J Genet Couns. doi:10.1007/s10897-014-9768-6
Coleman B et al (2014) Multi-ethnic minority nurses’ knowledge and practice of genetics and genomics. J Nurs Scholarsh : Off Publ Sigma Theta Tau Int Honor Soc Nurs / Sigma Theta Tau 46:235–244. doi:10.1111/jnu.12083
Corbie-Smith G (1999) The continuing legacy of the Tuskegee Syphilis Study: considerations for clinical investigation. Am J Med Sci 317:5–8
Crawford DC et al (2014) eMERGEing progress in genomics-the first seven years. Front Genet 5:184. doi:10.3389/fgene.2014.00184
Crosslin DR et al (2014) Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records. Front Genet 5:352. doi:10.3389/fgene.2014.00352
Department of Health and Human Services (2009) CRF 46.116. Department of Health and Human Services. http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.html#46.116. Accessed October 5, 2014
Dillman DA, Smyth JD, Christian LM, Dillman DA (2009) Internet, mail, and mixed-mode surveys: the tailored design method, 3rd edn. Wiley & Sons, Hoboken
Dillman DA, Smyth JD, Christian LM (2014) Internet, phone, mail, and mixed-mode surveys : the tailored design method, 4th edn. Wiley, Hoboken
Doak C, Doak L, Root J (1996) Teaching patients with low literacy skills, 2nd edn. Lippincott, Philadelpia
Edwards T, Cadigan RJ, Evans JP, Henderson GE (2014) Biobanks containing clinical specimens: defining characteristics, policies, and practices. Clin Biochem 47:245–251. doi:10.1016/j.clinbiochem.2013.11.023
Eisenhower A, Suyemoto K, Lucchese F, Canenguez K (2014) “Which box should I check?”: examining standard check box approaches to measuring race and ethnicity. Health Serv Res 49:1034–1055. doi:10.1111/1475-6773.12132
Evans M (2004) Healthcare’s minority report. Sullivan Commission, IOM try to make patient, hospital staff makeup more reflective of the nation’s ever-changing population. Mod Healthc 34(6–7):14–11
Foulkes MA (2011) After inclusion, information and inference: reporting on clinical trials results after 15 years of monitoring inclusion of women. J Women’s Health 20:829–836. doi:10.1089/jwh.2010.2527
Frieden TR, Centers for Disease C, Prevention (2011a) Forward: CDC health disparities and inequalities report—United States, 2011. Morb Mortal Wkly Rep Surveill Summ 60(Suppl):1–2
Frieden TR, Centers for Disease C, Prevention (2011b) Public health then and now: celebrating 50 years of MMWR at CDC. Foreword Morb Mortal Wkly Rep Surveill Summ 60(Suppl 4):1
Gill PS, Plumridge G, Khunti K, Greenfield S (2013) Under-representation of minority ethnic groups in cardiovascular research: a semi-structured interview study. Fam Pract 30:233–241. doi:10.1093/fampra/cms054
Green MA, Kim MM, Barber S, Odulana AA, Godley PA, Howard DL, Corbie-Smith GM (2013) Connecting communities to health research: development of the Project CONNECT minority research registry. Contemp Clin Trials 35:1–7. doi:10.1016/j.cct.2013.01.001
Henderson GE et al (2013) Characterizing biobank organizations in the U.S.: results from a national survey. Genome Med 5:3. doi:10.1186/gm407
Hoge SK, Appelbaum PS (2012) Ethics and neuropsychiatric genetics: a review of major issues. Int J Neuropsychopharmacol / Off Sci J Collegium Internationale Neuropsychopharmacologicum 15:1547–1557. doi:10.1017/S1461145711001982
Hurle B, Citrin T, Jenkins JF, Kaphingst KA, Lamb N, Roseman JE, Bonham VL (2013) What does it mean to be genomically literate?: National Human Genome Research Institute Meeting Report. Genet Med : Off J Am Coll Med Genet 15:658–663. doi:10.1038/gim.2013.14
Knerr S, Wayman D, Bonham VL (2011) Inclusion of racial and ethnic minorities in genetic research: advance the spirit by changing the rules? J Law Med Ethics : J Am Soc Law Med Ethics 39:502–512. doi:10.1111/j.1748-720X.2011.00617.x
Koretzky M, Bonham VL, Berkman BE, Kruszka P, Adeyemo A, Muenke M, Hull SC (2016) Towards a more representative morphology: clinical and ethical considerations for including diverse populations in diagnostic genetic atlases. Genet Med : Off J Am Coll Med Genet. doi:10.1038/gim.2016.7
Lachance CR, Erby LA, Ford BM, Allen VC Jr, Kaphingst KA (2010) Informational content, literacy demands, and usability of websites offering health-related genetic tests directly to consumers. Genet Med : Off J Am Coll Med Genet 12:304–312. doi:10.1097/GIM.0b013e3181dbd8b2
Larkey LK, Gonzalez JA, Mar LE, Glantz N (2009) Latina recruitment for cancer prevention education via community based participatory research strategies. Contemp Clin Trials 30:47–54. doi:10.1016/j.cct.2008.08.003
Lea DH, Kaphingst KA, Bowen D, Lipkus I, Hadley DW (2011) Communicating genetic and genomic information: health literacy and numeracy considerations. Public Health Genomics 14:279–289. doi:10.1159/000294191
Lindenstruth KA, Curtis CB, Allen JK (2006) Recruitment of African American and white postmenopausal women into clinical trials: the beneficial effects of soy trial experience. Ethn Dis 16:938–942
Liu AY et al (2016) Preexposure prophylaxis for HIV infection integrated with municipal- and community-based sexual health Services. JAMA Intern Med 176:75–84. doi:10.1001/jamainternmed.2015.4683
Louis AJ, Arora VM, Press VG (2014) Evaluating the brief health literacy screen. J Gen Intern Med 29:21. doi:10.1007/s11606-013-2655-2
Lu YF, Goldstein DB, Angrist M, Cavalleri G (2014) Personalized medicine and human genetic diversity. Cold Spring Harbor Perspect Med 4:a008581. doi:10.1101/cshperspect.a008581
Lynch HT, Drescher K, Knezetic J, Lanspa S (2014) Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review. Curr Treat Options in Oncol 15:429–442. doi:10.1007/s11864-014-0293-5
Madhivanan P, Valderrama D, Krupp K, Ibanez G (2016) Family and cultural influences on cervical cancer screening among immigrant Latinas in Miami-Dade County, USA. Cult Health Sex 18:710–722. doi:10.1080/13691058.2015.1116125
Marcantoni JR, Finney K, Lane MA (2014) Using health literacy guidelines to improve discharge education and the post-hospital transition: a quality improvement project. Am J Med Qual : Off J Am Coll Med Qual 29:86. doi:10.1177/1062860613508905
Martin A, Negron R, Balbierz A, Bickell N, Howell EA (2013) Recruitment of black and Latina women to a randomized controlled trial. J Health Care Poor Underserved 24:1102–1114. doi:10.1353/hpu.2013.0125
McCarty CA et al (2011) The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genet 4:13. doi:10.1186/1755-8794-4-13
McDonald JA et al (2014) Intentions to donate to a biobank in a national sample of African Americans. Public Health Genomics 17:173–182. doi:10.1159/000360472
Messiah A et al (2015) Combining community-based participatory research (CBPR) with a random-sample survey to assess smoking prevalence in an under-served community. J Natl Med Assoc 107:97–101. doi:10.1016/S0027-9684(15)30030-4
Modell SM, Citrin T, King SB, Kardia SL (2014) The role of religious values in decisions about genetics and the public’s health. J Relig Health 53:702–714. doi:10.1007/s10943-013-9814-y
Modell SM, Greendale K, Citrin T, Kardia SL (2016) Expert and advocacy group consensus findings on the horizon of public health genetic testing. Healthcare:4. doi:10.3390/healthcare4010014
Munday J (2016) Introducing translation studies: theories and applications Routledge, New York
Nakagawa K, Koenig MA, Asai SM, Chang CW, Seto TB (2013) Disparities among Asians and native Hawaiians and Pacific Islanders with ischemic stroke. Neurology 80:839–843. doi:10.1212/WNL.0b013e3182840797
Ritchie CS, Zulman DM (2013) Research priorities in geriatric palliative care: multimorbidity. J Palliat Med 16:843–847. doi:10.1089/jpm.2013.9491
Roberts D (2015) Can research on the genetics of intelligence be “socially neutral”? Hast Cent Rep 45:S50–S53. doi:10.1002/hast.499
Rosenberg NA, Huang L, Jewett EM, Szpiech ZA, Jankovic I, Boehnke M (2010) Genome-wide association studies in diverse populations. Nat Rev Genet 11:356–366. doi:10.1038/nrg2760
Siani M (2013) Mount Sinai Researchers will use $2.9 million nih grant to study disease in ethnically-diverse populations. Researchers will tap the Mount Sinai BioBank Program, BioMe™, which includes Electronic Medical Records on 29,000 patients. http://www.mountsinai.org/about-us/newsroom/press-releases/mount-sinai-researchers-will-use-29-million-nih-grant-to-study-disease-in-ethnically-diverse-populations. Accessed August 10, 2014
Sullivan PS, McNaghten AD, Begley E, Hutchinson A, Cargill VA (2007) Enrollment of racial/ethnic minorities and women with HIV in clinical research studies of HIV medicines. J Natl Med Assoc 99:242–250
Suther S, Kiros GE (2009) Barriers to the use of genetic testing: a study of racial and ethnic disparities. Genet Med 11:655–662. doi:10.1097/GIM.0b013e3181ab22aa
Tenorio SL, O’Donnell CI, Hernandez J, Rozjabek HM, Lynch D, Marcus PM (2014) Culturally sensitive approaches to recruitment and retention of Hispanics in the national lung screening trial. J Immigr Minor Health / Center Minor Public Health 16:761–764. doi:10.1007/s10903-013-9862-0
Toobert DJ, Strycker LA, King DK, Barrera M Jr, Osuna D, Glasgow RE (2011) Long-term outcomes from a multiple-risk-factor diabetes trial for Latinas: inverted exclamation markViva Bien! Transl Behav Med 1:416–426. doi:10.1007/s13142-010-0011-1
Yoon J, Zulman D, Scott JY, Maciejewski ML (2014) Costs associated with multimorbidity among VA patients. Med Care 52(Suppl 3):S31–S36. doi:10.1097/MLR.0000000000000061
Acknowledgements
Funding was provided by the Robert Wood Johnson Foundation Nurse Faculty Scholars Program Grant #72375 and National Human Genome Research Institute grant NHGRI P50 HG007257 and the National Institutes of Clinical and Translational Science UL1RR024156. The authors would like to thank the faculty of the Feinstein Institute for Medical Research at Northwell Health System, Dr. Peter Gregersen, and Marlena Kern for guidance in the development of the study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
All procedures were followed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all participants for being included in this study.
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Cohn, E.G., Hamilton, N., Larson, E.L. et al. Self-reported race and ethnicity of US biobank participants compared to the US Census. J Community Genet 8, 229–238 (2017). https://doi.org/10.1007/s12687-017-0308-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12687-017-0308-6