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Current status of the role of endoscopy in evaluation and management of gastrointestinal and pancreatic neuroendocrine tumors

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Abstract

The incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has increased over the last several decades. In general, NETs are slow-growing neoplasms and the data on the natural history is still evolving. The availability and improved utilization of advanced imaging modalities have allowed the selection of cases suitable for endotherapy. In this regard, endoscopic ultrasound (EUS) has emerged as a central imaging modality to assess the depth of infiltration in gastroduodenal as well as rectal NETs. Enhanced EUS modalities, including contrast-enhanced EUS and EUS elastography, reliably differentiate pancreatic neuroendocrine tumors (PNETs) from adenocarcinomas and may enable prediction of aggressive PNETs. With recent developments in therapeutic endoscopy, a large proportion of GEP-NETs can be safely managed endoscopically. Endoscopic resection techniques, including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), allow the safe removal of gastroduodenal and rectal NETs. Recent data indicate that modified EMR techniques may be superior to conventional EMR with regard to histologically complete resection. Device-assisted endoscopic full thickness resection is emerging as a safe and effective technique for upper gastrointestinal as well as rectal NETs. In selected cases with PNETs, who are otherwise unfit for surgery, EUS-guided ablation is increasingly being recognized as a safe treatment option. This review focusses on evidence-based approaches to endoscopic evaluation and the management of GEP-NETs with special emphasis on recent advancements.

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References

  1. Jamir TS, Badhe BA, Stephen N, Srinivas BH, Pottakkat B.  Clinicopathologic profile of gastroenteropancreatic neuroendocrine neoplasms in a referral center of South India. Int J Clin Exp Pathol. 2022;15:225–32.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Lee MR, Harris C, Baeg KJ, Aronson A, Wisnivesky JP, Kim MK. Incidence trends of gastroenteropancreatic neuroendocrine tumors in the United States. Clin Gastroenterol Hepatol. 2019;17:2212–7.e2211.

    Article  PubMed  Google Scholar 

  3. Palepu J, Shrikhande SV, Bhaduri D, et al. Trends in diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in India: A report of multicenter data from a web-based registry. Indian J Gastroenterol. 2017;36:445–51.

    Article  PubMed  Google Scholar 

  4. Yang J, Kim MK. What every gastroenterologist should know about gastrointestinal NETs. Am J Gastroenterol.  2023;118:606–9.

  5. Malla S, Kumar P, Madhusudhan KS. Radiology of the neuroendocrine neoplasms of the gastrointestinal tract: A comprehensive review. Abdom Radiol (NY). 2021;46:919–35.

    Article  PubMed  Google Scholar 

  6. Nagtegaal ID, Odze RD, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76:182–8.

    Article  PubMed  Google Scholar 

  7. Borbath I, Pape UF, Deprez PH, et al. ENETS standardized (synoptic) reporting for endoscopy in neuroendocrine tumors. J Neuroendocrinol. 2022;34:e13105.

    Article  CAS  PubMed  Google Scholar 

  8. Chen L, Guo Y, Zhang Y, et al. Development of a novel scoring system based on endoscopic appearance for management of rectal neuroendocrine tumors. Endoscopy. 2021;53:702–9.

    Article  PubMed  Google Scholar 

  9. Varas MJ, Gornals JB, Pons C, et al. Usefulness of endoscopic ultrasonography (EUS) for selecting carcinoid tumors as candidates to endoscopic resection. Rev Esp Enferm Dig. 2010;102:577–82.

    Article  CAS  PubMed  Google Scholar 

  10. Martinez-Ares D, Souto-Ruzo J, Varas Lorenzo MJ, et al. Endoscopic ultrasound-assisted endoscopic resection of carcinoid tumors of the gastrointestinal tract. Rev Esp Enferm Dig. 2004;96:847–55.

    Article  CAS  PubMed  Google Scholar 

  11. Ishii N, Horiki N, Itoh T, et al. Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors. Surg Endosc. 2010;24:1413–9.

    Article  PubMed  Google Scholar 

  12. Park SB, Kim DJ, Kim HW, et al. Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors? World J Gastroenterol. 2017;23:2037–43.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Shroff SR, Kushnir VM, Wani SB, et al. Efficacy of endoscopic mucosal resection for management of small duodenal neuroendocrine tumors. Surg Laparosc Endosc Percutan Tech. 2015;25:e134–139.

    Article  PubMed  Google Scholar 

  14. DelleFave G, O’Toole D, Sundin A, et al. ENETS Consensus Guidelines update for gastroduodenal neuroendocrine neoplasms. Neuroendocrinology. 2016;103:119–24.

    Article  CAS  Google Scholar 

  15. Ramage JK, De Herder WW, Delle Fave G, et al. ENETS Consensus Guidelines update for colorectal neuroendocrine neoplasms. Neuroendocrinology. 2016;103:139–43.

    Article  CAS  PubMed  Google Scholar 

  16. Paiella S, Landoni L, Rota R, et al. Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis and grading of pancreatic neuroendocrine tumors: A retrospective analysis of 110 cases. Endoscopy. 2020;52:988–94.

    Article  PubMed  Google Scholar 

  17. Leeds JS, Nayar MK, Bekkali NLH, et al. Endoscopic ultrasound-guided fine-needle biopsy is superior to fine-needle aspiration in assessing pancreatic neuroendocrine tumors. Endosc Int Open. 2019;7:E1281–7.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Crino SF, Ammendola S, Meneghetti A, et al. Comparison between EUS-guided fine-needle aspiration cytology and EUS-guided fine-needle biopsy histology for the evaluation of pancreatic neuroendocrine tumors. Pancreatology. 2021;21:443–50.

    Article  PubMed  Google Scholar 

  19. Carrara S, Di Leo M, Grizzi F, et al. EUS elastography (strain ratio) and fractal-based quantitative analysis for the diagnosis of solid pancreatic lesions. Gastrointest Endosc. 2018;87:1464–73.

    Article  PubMed  Google Scholar 

  20. Ignee A, Jenssen C, Arcidiacono PG, et al. Endoscopic ultrasound elastography of small solid pancreatic lesions: A multicenter study. Endoscopy. 2018;50:1071–9.

    Article  PubMed  Google Scholar 

  21. Palazzo M, Napoleon B, Gincul R, et al. Contrast harmonic EUS for the prediction of pancreatic neuroendocrine tumor aggressiveness (with videos). Gastrointest Endosc. 2018;87:1481–8.

    Article  PubMed  Google Scholar 

  22. Ishikawa R, Kamata K, Hara A, et al. Utility of contrast-enhanced harmonic endoscopic ultrasonography for predicting the prognosis of pancreatic neuroendocrine neoplasms. Dig Endosc. 2021;33:829–39.

    Article  PubMed  Google Scholar 

  23. Tsolakis AV, Ragkousi A, Vujasinovic M, Kaltsas G, Daskalakis K. Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis. World J Gastroenterol. 2019;25:5376–87.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Sekar A, Vaiphei K. Clinical and pathological profile of gastric neuroendocrine tumors. Indian J Pathol Microbiol. 2022;65:551–7.

    PubMed  Google Scholar 

  25. Panzuto F, Magi L, Esposito G, Rinzivillo M, Annibale B. Comparison of endoscopic techniques in the management of type I gastric neuroendocrine neoplasia: A systematic review. Gastroenterol Res Pract. 2021;2021:6679397.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Li YL, Qiu XD, Chen J, et al. Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours. World J Gastrointest Oncol. 2020;12:1416–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Exarchou K, Kamieniarz L, Tsoli M, et al. Is local excision sufficient in selected grade 1 or 2 type III gastric neuroendocrine neoplasms? Endocrine. 2021;74:421–9.

    Article  CAS  PubMed  Google Scholar 

  28. Hirasawa T, Yamamoto N, Sano T. Is endoscopic resection appropriate for type 3 gastric neuroendocrine tumors? Retrospective multicenter study. Dig Endosc. 2021;33:408–17.

    Article  PubMed  Google Scholar 

  29. Kwon YH, Jeon SW, Kim GH, et al. Long-term follow up of endoscopic resection for type 3 gastric NET. World J Gastroenterol. 2013;19:8703–8.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Hanna A, Kim-Kiselak C, Tang R, et al. Gastric neuroendocrine tumors: reappraisal of type in predicting outcome. Ann Surg Oncol. 2021;28:8838–46.

    Article  PubMed  Google Scholar 

  31. Ruff SM, Standring O, Wu G, et al. Ampullary neuroendocrine tumors: Insight into a rare histology. Ann Surg Oncol. 2021;28:8318–28.

    Article  PubMed  Google Scholar 

  32. Margonis GA, Samaha M, Kim Y, et al. A multi-institutional analysis of duodenal neuroendocrine tumors: Tumor biology rather than extent of resection dictates prognosis. J Gastrointest Surg. 2016;20:1098–105.

    Article  PubMed  Google Scholar 

  33. Lee SW, Sung JK, Cho YS, et al. Comparisons of therapeutic outcomes in patients with nonampullary duodenal neuroendocrine tumors (NADNETs): A multicenter retrospective study. Medicine (Baltimore). 2019;98:e16154.

    Article  PubMed  Google Scholar 

  34. Kim GH, Kim JI, Jeon SW, et al. Endoscopic resection for duodenal carcinoid tumors: A multicenter, retrospective study. J Gastroenterol Hepatol. 2014;29:318–24.

    Article  PubMed  Google Scholar 

  35. Fujimoto A, Sasaki M, Goto O, et al. Treatment results of endoscopic mucosal resection with a ligation device for duodenal neuroendocrine tumors. Intern Med. 2019;58:773–7.

    Article  PubMed  Google Scholar 

  36. Mahmud N, Tomizawa Y, Stashek K, Katona BW, Ginsberg GG, Metz DC. Endoscopic resection of duodenal carcinoid tumors: A single-center comparison between simple polypectomy and endoscopic mucosal resection. Pancreas. 2019;48:60–5.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Gincul R, Ponchon T, Napoleon B, et al. Endoscopic treatment of sporadic small duodenal and ampullary neuroendocrine tumors. Endoscopy. 2016;48:979–86.

    Article  PubMed  Google Scholar 

  38. Kim TW, Kim GH, Park DY, et al. Endoscopic resection for duodenal subepithelial tumors: A single-center experience. Surg Endosc. 2017;31:1936–46.

    Article  PubMed  Google Scholar 

  39. Park SB,Park SB, Kang DH, Choi CW, Kim HW, Kim SJ. Clinical outcomes of ligation-assisted endoscopic resection for duodenal neuroendocrine tumors. Medicine (Baltimore). 2018;97:e0533.

    Article  PubMed  Google Scholar 

  40. Matsumoto S, Miyatani H, Yoshida Y, Nokubi M. Duodenal carcinoid tumors: 5 cases treated by endoscopic submucosal dissection. Gastrointest Endosc. 2011;74:1152–6.

    Article  PubMed  Google Scholar 

  41. Scherer JR, Holinga J, Sanders M, et al. Small duodenal carcinoids: A case series comparing endoscopic resection and autoamputation with band ligation. J Clin Gastroenterol. 2015;49:289–92.

    Article  PubMed  Google Scholar 

  42. Hatta W, Koike T, Iijima K, et al. The risk factors for metastasis in non-ampullary duodenal neuroendocrine tumors measuring 20 mm or less in diameter. Digestion. 2017;95:201–9.

    Article  PubMed  Google Scholar 

  43. Nishio M, Hirasawa K, Ozeki Y, et al. Short- and long-term outcomes of endoscopic submucosal dissection for non-ampullary duodenal neuroendocrine tumors. Ann Gastroenterol. 2020;33:265–71.

    PubMed  PubMed Central  Google Scholar 

  44. Hamada K, Irisawa A, Horikawa Y, et al. Neuroendocrine tumor of the ampulla of Vater treated with endoscopic papillectomy: A case report. DEN Open. 2023;3:e191.

    Article  PubMed  Google Scholar 

  45. Shimai S, Yamamoto K, Sofuni A, et al. Three cases of ampullary neuroendocrine tumor treated by endoscopic papillectomy: A case report and literature review. Intern Med. 2020;59:2369–74.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Tran CG, Sherman SK, Suraju MO, et al. Management of duodenal neuroendocrine tumors: surgical versus endoscopic mucosal resection. Ann Surg Oncol. 2022;29:75–84.

    Article  PubMed  Google Scholar 

  47. Brito HP, Torres IT, Turke KC, Parada AA, Waisberg J, Botelho RV. Comparison of endoscopic resection techniques for duodenal neuroendocrine tumors: systematic review. Endosc Int Open. 2021;9:E1214–21.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Khara HS, Shovlin GJ, Johal AS, Diehl DL. Endoscopic banding without resection (BWR) technique for treatment of diminutive neuroendocrine tumors in the duodenum. Endosc Int Open. 2019;7:E302–7.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Nabi Z, Ramchandani M, Asif S, et al. Outcomes of endoscopic submucosal dissection in duodenal neuroendocrine tumors. J Gastrointest Surg. 2022;26:275–7.

    Article  PubMed  Google Scholar 

  50. Kappelle WFW, Backes Y, Valk GD, Moons LMG, Vleggaar FP. Endoscopic full-thickness resection of gastric and duodenal subepithelial lesions using a new, flat-based over-the-scope clip. Surg Endosc. 2018;32:2839–46.

    Article  PubMed  Google Scholar 

  51. Andrisani G, Di Matteo FM. Endoscopic full-thickness resection of duodenal lesions (with video). Surg Endosc. 2020;34:1876–81.

    Article  PubMed  Google Scholar 

  52. Yamaguchi T, Takahashi K, Yamada K, et al. A nationwide, multi-institutional collaborative retrospective study of colorectal neuroendocrine tumors in Japan. Ann Gastroenterol Surg. 2021;5:215–20.

    Article  PubMed  Google Scholar 

  53. Fine C, Roquin G, Terrebonne E, et al. Endoscopic management of 345 small rectal neuroendocrine tumours: A national study from the French group of endocrine tumours (GTE). United European Gastroenterol J. 2019;7:1102–12.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Pattarajierapan S, Khomvilai S. Recurrence after endoscopic resection of small rectal neuroendocrine tumors: A retrospective cohort study. Ann Coloproctol. 2022;38:216–22.

    Article  PubMed  Google Scholar 

  55. Chung HG, Goh MJ, Kim ER, et al. Recurrence pattern and surveillance strategy for rectal neuroendocrine tumors after endoscopic resection. J Gastroenterol Hepatol. 2021;36:968–73.

    Article  PubMed  Google Scholar 

  56. Kim J, Kim JH, Lee JY, Chun J, Im JP, Kim JS. Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor. BMC Gastroenterol. 2018;18:77.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Kuiper T, van Oijen MGH, van Velthuysen MF, et al. Endoscopically removed rectal NETs: A nationwide cohort study. Int J Colorectal Dis. 2021;36:535–41.

    Article  PubMed  Google Scholar 

  58. Son J, Park IJ, Yang DH, et al. Oncological outcomes according to the treatment modality based on the size of rectal neuroendocrine tumors: a single-center retrospective study. Surg Endosc. 2022;36:2445–55.

    Article  PubMed  Google Scholar 

  59. Sun P, Zheng T, Hu C, Gao T, Ding X. Comparison of endoscopic therapies for rectal neuroendocrine tumors: endoscopic submucosal dissection with myectomy versus endoscopic submucosal dissection. Surg Endosc. 2021;35:6374–8.

    Article  PubMed  Google Scholar 

  60. Park SS, Han KS, Kim B, et al. Comparison of underwater endoscopic mucosal resection and endoscopic submucosal dissection of rectal neuroendocrine tumors (with videos). Gastrointest Endosc. 2020;91:1164-71.e1162.

    Article  PubMed  Google Scholar 

  61. Meier B, Albrecht H, Wiedbrauck T, Schmidt A, Caca K. Full-thickness resection of neuroendocrine tumors in the rectum. Endoscopy. 2020;52:68–72.

    Article  PubMed  Google Scholar 

  62. Kim J, Kim J, Oh EH, et al. Anchoring the snare tip is a feasible endoscopic mucosal resection method for small rectal neuroendocrine tumors. Sci Rep. 2021;11:12918.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Zhou X, Xie H, Xie L, Li J, Cao W, Fu W. Endoscopic resection therapies for rectal neuroendocrine tumors: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29:259–68.

    Article  PubMed  Google Scholar 

  64. Lee HS, Moon HS, Kwon IS, et al. Comparison of conventional and modified endoscopic mucosal resection methods for the treatment of rectal neuroendocrine tumors. Surg Endosc. 2021;35:6055–65.

    Article  PubMed  Google Scholar 

  65. Zheng JC, Zheng K, Zhao S, et al. Efficacy and safety of modified endoscopic mucosal resection for rectal neuroendocrine tumors: A meta-analysis. Z Gastroenterol. 2020;58:137–45.

    Article  PubMed  Google Scholar 

  66. Choi CW, Kang DH, Kim HW, et al. Comparison of endoscopic resection therapies for rectal carcinoid tumor: Endoscopic submucosal dissection versus endoscopic mucosal resection using band ligation. J Clin Gastroenterol. 2013;47:432–6.

    Article  PubMed  Google Scholar 

  67. Yang DH, Park Y, Park SH, et al. Cap-assisted EMR for rectal neuroendocrine tumors: comparisons with conventional EMR and endoscopic submucosal dissection (with videos). Gastrointest Endosc. 2016;83:1015–22 (quiz 1023-.e6).

  68. Pan J, Zhang X, Shi Y, Pei Q. Endoscopic mucosal resection with suction vs. endoscopic submucosal dissection for small rectal neuroendocrine tumors: A meta-analysis. Scand J Gastroenterol. 2018;53:1139–45.

    Article  PubMed  Google Scholar 

  69. Yong JN, Lim XC, Nistala KRY, et al. Endoscopic submucosal dissection versus endoscopic mucosal resection for rectal carcinoid tumor. A meta-analysis and meta-regression with single-arm analysis. J Dig Dis. 2021;22:562–71.

    Article  PubMed  Google Scholar 

  70. Lakhtakia S, Ramchandani M, Galasso D, et al. EUS-guided radiofrequency ablation for management of pancreatic insulinoma by using a novel needle electrode (with videos). Gastrointest Endosc. 2016;83:234–9.

    Article  PubMed  Google Scholar 

  71. Paik WH, Seo DW, Dhir V, Wang HP. Safety and efficacy of EUS-guided ethanol ablation for treating small solid pancreatic neoplasm. Medicine (Baltimore). 2016;95:e2538.

    Article  CAS  PubMed  Google Scholar 

  72. Choi JH, Park DH, Kim MH, et al. Outcomes after endoscopic ultrasound-guided ethanol-lipiodol ablation of small pancreatic neuroendocrine tumors. Dig Endosc. 2018;30:652–8.

    Article  PubMed  Google Scholar 

  73. Choi JH, Seo DW, Song TJ, et al. Endoscopic ultrasound-guided radiofrequency ablation for management of benign solid pancreatic tumors. Endoscopy. 2018;50:1099–104.

    Article  PubMed  Google Scholar 

  74. Barthet M, Giovannini M, Lesavre N, et al. Endoscopic ultrasound-guided radiofrequency ablation for pancreatic neuroendocrine tumors and pancreatic cystic neoplasms: A prospective multicenter study. Endoscopy. 2019;51:836–42.

    Article  PubMed  Google Scholar 

  75. Oleinikov K, Dancour A, Epshtein J, et al. Endoscopic ultrasound-guided radiofrequency ablation: A new therapeutic approach for pancreatic neuroendocrine tumors. J Clin Endocrinol Metab. 2019;104:2637–47.

    Article  PubMed  Google Scholar 

  76. Barthet M, Giovannini M, Gasmi M, et al. Long-term outcome after EUS-guided radiofrequency ablation: Prospective results in pancreatic neuroendocrine tumors and pancreatic cystic neoplasms. Endosc Int Open. 2021;9:E1178–85.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Choi JH, Seo DW, Song TJ, et al. Utility of contrast-enhanced harmonic endoscopic ultrasound for the guidance and monitoring of endoscopic radiofrequency ablation. Gut Liver. 2020;14:826–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. de Nucci G, Imperatore N, Mandelli ED, di Nuovo F, d'Urbano C, Manes G. Endoscopic ultrasound-guided radiofrequency ablation of pancreatic neuroendocrine tumors: a case series. Endosc Int Open. 2020;8:E1754–8.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Park DH, Choi JH, Oh D, et al. Endoscopic ultrasonography-guided ethanol ablation for small pancreatic neuroendocrine tumors: Results of a pilot study. Clin Endosc. 2015;48:158–64.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Matsumoto K, Kato H, Kawano S, et al. Efficacy and safety of scheduled early endoscopic ultrasonography-guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study. Dig Endosc. 2020;32:425–30.

    Article  PubMed  Google Scholar 

  81. Imperatore N, de Nucci G, Mandelli ED, et al. Endoscopic ultrasound-guided radiofrequency ablation of pancreatic neuroendocrine tumors: A systematic review of the literature. Endosc Int Open. 2020;8:E1759–64.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Zhang L, Tan S, Huang S, et al. The safety and efficacy of endoscopic ultrasound-guided ablation therapy for solid pancreatic tumors: A systematic review. Scand J Gastroenterol. 2020;55:1121–31.

    Article  CAS  PubMed  Google Scholar 

  83. Kunz PL, Reidy-Lagunes D, Anthony LB, et al. Consensus guidelines for the management and treatment of neuroendocrine tumors. Pancreas. 2013;42:557–77.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Falconi M, Eriksson B, Kaltsas G, et al. ENETS Consensus Guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors. Neuroendocrinology. 2016;103:153–71.

    Article  CAS  PubMed  Google Scholar 

  85. Pavel M, Oberg K, Falconi M, et al. Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31:844–60.

    Article  CAS  PubMed  Google Scholar 

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  1. Asian Institute of Gastroenterology, Hyderabad, 500 082, India

    Zaheer Nabi, Sundeep Lakhtakia & D. Nageshwar Reddy

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Societal guidelines for the management of gastroenteropancreatic NETs

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Novel technique of endoscopic submucosal dissection in a case with duodenal NET (MP4 202437 KB)

Case study examples for standard reporting of endoscopy in NETs (DOCX 33 KB)

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Nabi, Z., Lakhtakia, S. & Reddy, D.N. Current status of the role of endoscopy in evaluation and management of gastrointestinal and pancreatic neuroendocrine tumors. Indian J Gastroenterol 42, 158–172 (2023). https://doi.org/10.1007/s12664-023-01362-8

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