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Chicago Classification of esophageal motility disorders: Past, present, and future

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Abstract

The Chicago Classification (CC) is a dynamic, evolving classification scheme created by a diverse group of international esophageal experts. Its application has transformed the way esophageal motor data are used to define motility disorders, each iteration seeking to advance, simplify, and standardize the way clinicians worldwide diagnose esophageal dysmotility. The most recent update, CC version 4.0 (CCv4.0), emphasizes the importance of clinical context and distinguishes clinically relevant, conclusive manometric diagnoses from irrelevant manometric observations. Future iterations of CC may refine the classification of spastic esophageal disorders and incorporate machine learning and physics-based modeling to improve metrics.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, 12631 E. 17th Ave. MS B-158, Aurora, CO, 80045, USA

    Kelli DeLay

  2. Center for Esophageal Diseases, Division of Gastroenterology, University of California, San Diego School of Medicine, La Jolla, CA, USA

    Rena Yadlapati

  3. Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    John E. Pandolfino

Authors
  1. Kelli DeLay
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  2. Rena Yadlapati
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  3. John E. Pandolfino
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Corresponding author

Correspondence to Kelli DeLay.

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Conflict of Interest

Rena Yadlapati: Institutional Consulting Agreement: Medtronic, Ironwood Pharmaceuticals, Diversatek; Consultant: Phathom Pharmaceuticals; Research support: Ironwood Pharmaceuticals; Advisory Board with Stock Options: RJS Mediagnostix

John E. Pandolfino: Consultant: Medtronic, Ironwood Pharmaceuticals, Diversatek; Research support: Ironwood Pharmaceuticals, Takeda; Advisory Board: Medtronic, Diversatek; Stock Options: Crospon Inc

Kelli DeLay: None

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The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology or the printer/publishers are responsible for the results/findings and content of this article.

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DeLay, K., Yadlapati, R. & Pandolfino, J.E. Chicago Classification of esophageal motility disorders: Past, present, and future. Indian J Gastroenterol 40, 120–130 (2021). https://doi.org/10.1007/s12664-021-01162-y

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  • DOI: https://doi.org/10.1007/s12664-021-01162-y

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