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From clinical practice guideline development to trial registration: A systematic investigation of research pipeline for inflammatory bowel disease

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Indian Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

Clinical practice guidelines help practitioners manage patients in an effective and systematic way, and they assist in making evidence-based decisions related to diagnosis and treatment. Each recommendation is ranked based on evidence. The goal of this study is to determine gaps in research for inflammatory bowel diseases (IBD) by using the low-level evidence recommendations.

Methods

We extracted low-level evidence recommendations set forth by the American College of Gastroenterology in IBD, ulcerative colitis (UC), and Crohn’s disease. ClinicalTrials.gov, the World Health Organization’s International Clinical Trials Registry Platform and PubMed were then used to locate studies relevant to the recommendations.

Results

There were 30 low-level evidence recommendations, and 23 had recent or ongoing studies addressing them. We screened 2938 trials and 4321 published articles, 221 of which addressed low-quality recommendations. There were five recommendations that received the majority of research attention (143/221, 65%).

Conclusion

This study used clinical practice guidelines to help determine areas of needed research in IBD, UC, and Crohn’s disease. By searching trial registries and articles indexed on PubMed, we identified the extent to which studies were being conducted to address research gaps. Of the gaps identified, five recommendations received most of the attention. While most of the significant gaps had some recent or ongoing research, our study found several areas where investigation is still needed. Clinical practice guidelines are an effective method to prioritize future research.

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Funding

This work was supported by a grant from Crohn’s and Colitis Foundation of America. The funding agreement ensured the authors’ independence in designing the study, interpreting the data, writing, and publishing the report. No authors were employed by the funding source. No financial disclosures were reported by the authors of this paper.

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Authors and Affiliations

  1. Center for Health Sciences, Oklahoma State University, 1111 W 17th Street, Tulsa, OK, 74107, USA

    Chase Meyer, Aaron Bowers, Jake X. Checketts & Matt Vassar

  2. Department of Internal Medicine, Baylor Scott and White Medical Center-Temple, 2401 South 31st Street, Temple, TX, 76508, USA

    Trace E. Heavener

Authors
  1. Chase Meyer
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  2. Aaron Bowers
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  3. Trace E. Heavener
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  4. Jake X. Checketts
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  5. Matt Vassar
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Contributions

Matt Vassar developed the protocol for the study and aided in writing the manuscript. Chase Meyer aided in data collection and also writing the manuscript. Aaron Bowers, Trace E. Heavener, and Jake X. Checketts all aided in data extraction. Chase Meyer confirms full access to all aspects of the research and writing process and takes final responsibility for the paper.

Corresponding author

Correspondence to Trace E. Heavener.

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Conflict of interest

CM, AB, TEH, JXC, and MV declare that they have no conflict of interest.

Ethics statement

The authors declare that the study was performed in a manner conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer. com.

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The authors are solely responsible for the data and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, or the printer/publishers are responsible for the results/ findings and content of this article.

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Financial support for this study was provided entirely by a grant from Crohn’s and Colitis Foundation of America. The funding agreement ensured the authors’ independence in designing the study, interpreting the data, writing, and publishing the report. No authors were employed by the funding source. No financial disclosures were reported by the authors of this paper.

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Meyer, C., Bowers, A., Heavener, T.E. et al. From clinical practice guideline development to trial registration: A systematic investigation of research pipeline for inflammatory bowel disease. Indian J Gastroenterol 38, 247–262 (2019). https://doi.org/10.1007/s12664-019-00965-4

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  • DOI: https://doi.org/10.1007/s12664-019-00965-4

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