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Comparison of Wrinkle Patterns Generated by Intradermal and Intramuscular Botulinum Toxin Injections by Clinical Evaluation

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Purpose

Botulinum toxin has played a remarkable role in management of forehead wrinkles. Most used is intramuscular technique due to its deposition into the muscles, however, with adverse effects like brow ptosis. This study has been designed for the evaluation of efficacy for intradermal v/s intramuscular route of botulinum toxin injections for forehead wrinkles using clinical correlation.

Methods

This study included a clinical trial of 32 facial halves divided equally into intradermal and intramuscular injection technique groups, receiving total dose of 8 U. Results were assessed by clinical examination upto 2 weeks and 4 weeks with parameters; objective wrinkle rate, eyebrow height, eyebrow movement, pain, and satisfaction after treatment.

Result

Results showed least mean for objective wrinkle rate in intramuscular group, showing statistically significant improvement. Overall improvement in eyebrow height and eyebrow movement were slightly more for intramuscular group. Pain was lesser for intradermal group, whereas satisfaction of patient of patient post treatment is similar for both the groups.

Conclusion

Among intradermal and intramuscular botulinum toxin injection technique, the effect and potency were better for intramuscular technique, whereas the patient comfort and compliance were better for intradermal technique.

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Acknowledgements

The authors would like to thank the SRM Institute of Science and Technology, Tamil Nadu, India for support to carry out this research.

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Author notes

  1. Elavenil Panneerselvam

    Present address: SRM Dental College, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, 600089, India

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, SRM Dental College & Hospital, Ramapuram Campus, Ramapuram, Chennai, 600089, India

    Rituparna Mitra, V. B. Krishna Kumar Raja & Elavenil Panneerselvam

Authors
  1. Rituparna Mitra
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  2. V. B. Krishna Kumar Raja
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  3. Elavenil Panneerselvam
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Correspondence to Elavenil Panneerselvam.

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Ethical statement

Ethical approval of this study has been obtained from the Institutional Review Board- SRMDC/IRB/2020/MDS/No.403.

Informed consent

No. of human participants involved in the study: 16 nos. Informed consent obtained from all the participants.

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Mitra, R., Raja, V.B.K.K. & Panneerselvam, E. Comparison of Wrinkle Patterns Generated by Intradermal and Intramuscular Botulinum Toxin Injections by Clinical Evaluation. J. Maxillofac. Oral Surg. (2024). https://doi.org/10.1007/s12663-024-02141-4

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  • DOI: https://doi.org/10.1007/s12663-024-02141-4

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