Abstract
Background
Oral cancer (OC) is the sixth most common cancer worldwide. There have been few studies on OC in high-risk populations. This study aimed to describe the clinical features, staging, grading, and risk factors in OC patients.
Methods
This cross-sectional study was conducted on 109 OC patients diagnosed and treated from April 2018 to May 2020. The patients were identified using eData.
Results
The average age of the patients was 60.32 ± 12.4 years, and the male-to-female ratio was 2.9:1. The most common site for OC was the tongue (37.6%), and oral squamous cell carcinoma was the most common histopathology (84.4%). The most common clinical forms were verruca (37.6%) and erosive ulcers (33.9%). Most patients were in stage III or IV (71.6%). Average time of detection was 7.32 ± 17.12 months.
Conclusions
OC occurs most often in elderly people, males, and is diagnosed late. The main risk factors are smoking and consuming alcohol.
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References
Panta P (2019) Oral cancer detection: Novel strategies and clinical impact. Springer, Berlin
Nunez-Gonzalez S, Delgado-Ron JA, Gault C, Simancas-Racines D (2018) Trends and spatial patterns of oral cancer mortality in Ecuador, 2001–2016. Int J Dent 2018:6086595
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
Miguelanez-Medran BC, Pozo-Kreilinger JJ, Cebrian-Carretero JL, Martinez-Garcia MA, Lopez-Sanchez AF (2019) Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study. Med Oral Patol Oral Cir Bucal 24(5):e603-e609
Priebe SL, Aleksejuniene J, Zed C, Dharamsi S, Thinh DH, Hong NT et al (2010) Oral squamous cell carcinoma and cultural oral risk habits in Vietnam. Int J Dent Hyg 8(3):159–168
Kuriakose MA. Contemporary Oral Oncology: Diagnosis and Management: Springer; 2016.
Pfister DG, Spencer S, Adelstein D, Adkins D, Anzai Y, Brizel DM, et al (2020) Head and neck cancers, version 2.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 18(7):873–898
Agarwal P, Agrawal RR, Jones EA, Devaiah AK (2020) Social determinants of health and oral cavity cancer treatment and survival: a competing risk analysis. Laryngoscope 130(9):2160–2165
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M et al (2018) Oral cancer: a multicenter study. Med Oral Patol Oral Cir Bucal 23(1):e23–e29
Patel MM, Pandya AN (2004) Relationship of oral cancer with age, sex, site distribution and habits. Indian J Pathol Microbiol 47(2):195–197
Dias GS, Almeida AP (2007) A histological and clinical study on oral cancer: descriptive analyses of 365 cases. Med Oral Patol Oral Cir Bucal 12(7):E474–E478
da Silva Lins LS, Bezerra NVF, Freire AR, de Almeida LdFD, de Lucena EHG, Cavalcanti YW (2019) Socio-demographic characteristics are related to the advanced clinical stage of oral cancer. Medicina oral, patologia oral y cirugia bucal 24(6):e759
Chang WC, Chang CF, Li YH, Yang CY, Su RY, Lin CK et al (2019) A histopathological evaluation and potential prognostic implications of oral squamous cell carcinoma with adverse features. Oral Oncol 95:65–73
Chher T, Hak S, Kallarakkal TG, Durward C, Ramanathan A, Ghani WMN et al (2018) Prevalence of oral cancer, oral potentially malignant disorders and other oral mucosal lesions in Cambodia. Ethn Health 23(1):1–15
Lee YA, Li S, Chen Y, Li Q, Chen CJ, Hsu WL et al (2019) Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population. Head Neck 41(1):92–102
Jiang X, Wu J, Wang J, Huang R (2019) Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways. Tob Induc Dis 17:29
Awan KH, Hegde R, Cheever VJ, Carroll W, Khan S, Patil S et al (2018) Oral and pharyngeal cancer risk associated with occupational carcinogenic substances: systematic review. Head Neck 40(12):2724–2732
Brasil VLM, Ramos Pinto MB, Bonan RF, Kowalski LP, da Cruz Perez DE (2018) Pesticides as risk factors for head and neck cancer: a review. J Oral Pathol Med 47(7):641–651
Krishna Rao SV, Mejia G, Roberts-Thomson K, Logan R (2013) Epidemiology of oral cancer in Asia in the past decade–an update (2000–2012). Asian Pac J Cancer Prev 14(10):5567–5577
Somanna SN, Sastry NB, Cheluvarayaswamy R, Sabitha K, Srinivasa MN, Malila N (2018) Time span from onset of oral cancer symptoms to treatment: a hospital based cross sectional study in South India. Int J Community Med Public Health 5:5082
Bugshan A, Farooq I (2020) Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. F1000Res 9:229
Jehannin-Ligier K, Dejardin O, Lapotre-Ledoux B, Bara S, Coureau G, Grosclaude P et al (2017) Oral cancer characteristics in France: Descriptive epidemiology for early detection. J Stomatol Oral Maxillofac Surg 118(2):84–89
Thomson PJ (2018) Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction. J Oral Pathol Med 47(9):803–807
Andreadis DA, Pavlou A-M, Panta P (2019) Biopsy and oral squamous cell carcinoma histopathology. In: Panta P (ed) Oral cancer detection. Springer International Publishing, Cham, pp 133–151
Kreppel M, Nazarli P, Grandoch A, Safi AF, Zirk M, Nickenig HJ et al (2016) Clinical and histopathological staging in oral squamous cell carcinoma - Comparison of the prognostic significance. Oral Oncol 60:68–73
Acknowledgements
We would like to express our appreciation to all the staff members of the Department of Surgery 1 and the Department of Radiology in Can Tho City Oncology Hospital.
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Do, T.T., Bui, L.N.V., Nguyen, L. et al. Clinical and Pathological Features of Oral Cancer in a High-Risk Community in Vietnam. J. Maxillofac. Oral Surg. (2023). https://doi.org/10.1007/s12663-023-01997-2
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DOI: https://doi.org/10.1007/s12663-023-01997-2