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Exploring an Unfathomed Entiry: A Pooled Analysis of Solitory Skeletal Muscle Metastasis from Head and Neck Squamous Cell Carcinoma

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Background

Skeletal muscle is relatively uncommon site for metastasis in head and neck primary. This study was conducted to report our experience of three such cases and analyze the previously reported cases to assess the overall outcomes and formulate a treatment plan for these patients.

Methods

We pooled the data extracted on extensive literature review and analyzed.

Results

A total of 17 patients were analyzed for this study. All the patients had locally advanced primary and 14/17 developed metachronous metastasis. Median duration to development of metastasis was 8.5 months, and 13/17 patients had skeletal muscle as the only site of metastasis. Only 6/13 were treated with aggressive intent, 4 of which who underwent surgical resection had the best survival outcomes.

Conclusions

Isolated skeletal muscle metastasis in a head and neck primary is relatively rare, and in future, the research work needs to be taken up afresh, on prospective model, with adequate patient sample, to draw a scientifically valid conclusion.

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Authors and Affiliations

  1. Department of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India

    Dharma Ram Poonia

  2. Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

    Dharma Ram Poonia, Suhas Kodasoge Rajappa & Ajay K. Dewan

  3. Department of Medical Oncology, All India Institute of Medical Sciences, Rishikesh, India

    Amit Sehrawat

  4. Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

    Chaturbhuj Agrawal & Koyyala Venkata Pradeep Babu

Authors
  1. Dharma Ram Poonia
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  2. Suhas Kodasoge Rajappa
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  3. Ajay K. Dewan
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  6. Koyyala Venkata Pradeep Babu
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Correspondence to Dharma Ram Poonia.

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The study was a retrospective analysis and pooled analysis of published reports. No human or animal was involved or no intervention has been done.

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The study was a retrospective analysis and pooled analysis of published reports. Informed consent from discussed individuals was taken.

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Poonia, D.R., Rajappa, S.K., Dewan, A.K. et al. Exploring an Unfathomed Entiry: A Pooled Analysis of Solitory Skeletal Muscle Metastasis from Head and Neck Squamous Cell Carcinoma. J. Maxillofac. Oral Surg. 21, 176–183 (2022). https://doi.org/10.1007/s12663-020-01353-8

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  • DOI: https://doi.org/10.1007/s12663-020-01353-8

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