Abstract
Background
Osteosarcomas of head and neck region have unique biology and exhibit a clinical behavior and natural history that is distinct from osteosarcomas of the trunk and extremities. Our understanding of this malignant bone tumor is largely based on data from single institutions or compiled from registries, and hence the clinical practice guidelines seem confusing and conflicting.
Aims and Objectives
To analyze the demographic profile, disease characteristics and survival outcomes of osteosarcoma of head and neck region.
Materials and Methods
Retrospective analysis of the patients treated for osteosarcoma of head and neck region with curative intent in the period between the years 2001–2013 at a tertiary cancer center from South India.
Results
A total of 14 patients were treated in the said period with a mean age of 37 years. The most common site was mandible (n = 9 patients) followed by maxilla (n = 4) and paranasal sinuses (n = 1). Conventional osteoblastic variant of OS was the most common histological variant (n = 8) followed by the chondroblastic variant (n = 5). The median disease-free survival was 41.7 months, whereas the median overall survival of our patient cohort was 47.6 months. A formal analysis of various prognostic factors showed only postoperative margin positivity to be the single important factor affecting the survival outcomes.
Conclusion
Head and neck osteosarcoma that most commonly afflicts the jaw bones occurs in the fourth decade of life. Despite being a small series, our study does highlight the importance of achieving a margin-negative resection as a part of the multimodality treatment of head and neck osteosarcomas. Considering the relative paucity of data, there is a need for multi-institutional collaborative studies to refine the therapeutic strategies for the management of patients with head and neck osteosarcomas.
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References
Lim S, Lee S, Rha SY, Rho JK (2016) Cranofacial osteosarcoma: single institutional experience in Korea. Asia Pac J Clin Oncol 12:e149–e153
Sturgis EM, Potter BO (2003) Sarcomas of the head and neck region. Curr Opin Oncol 15:239–252
Clark JL, Unni KK, Dahlin DC, Devine KD (1983) Osteosarcoma of the jaw. Cancer 51:2311–2316
Guadagnolo BA, Zagars GK, Raymond AK, Benjamin RS, Sturgis EM (2009) Osteosarcoma of the jaw/craniofacial region. Cancer 115:3262–3270
Jasnau S, Meyer U, Potratz J, Jundt G, Kevric M, Joos UK et al (2008) Craniofacial osteosarcoma experience of the cooperative German–Austrian–Swiss osteosarcoma study group. Oral Oncol 44:286–294
Mark KJ, Sercarz JÁ, Tran L, Dodd LG, Selch M, Calcaterra TC (1991) Osteosarcoma of the head and neck. The UCLA experience. Arch Otolaryngol Head Neck Surg 117:761–766
Bertoni F, Dallera P, Bacchini P, Marchetti C, Campobassi A (1991) The Instituto Rizzoli–Beretta experience with osteosarcoma of the jaw. Cancer 68:1555–1563
Junior AT, Alves FAD et al (2002) Head and neck osteosarcomas—a review of the literature. Braz J Oral Sci 1:112–115
Canadian Society of Otolaryngology-Head and Neck Surgery Oncology Study Group (2004) Osteogenic sarcoma of the mandible and maxilla: a Canadian review (1980–2000). J Otolaryngol 33:139–144
Nissanka E, Amaratunge E, Tilakaratne W (2007) Clinicopathological analysis of osteosarcoma of jaw bones. Oral Dis 13:82–87
Dickens P, Wei WI, Sham JST (1990) Osteosarcoma of the maxilla in Hong Kong. Chinese postirradiation for nasopharyngeal carcinoma. Cancer 66:1924–1926
Bennett JH, Thomas G, Evans AW, Speith PM (2000) Osteosarcoma of the jaws: a 30-year retrospective review. Oral Surg Oral Med Oral Pathol 90:323–333
Mardinger O, Givol N, Talmi Y, Taicher S (2001) Osteosarcoma of the jaw: the Chaim Sheba Medical Center experience. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:445–451
Clark J, Unni K, Dahlin D, Devin K (1983) Osteosarcoma of the jaw. Cancer 51(2311–231):6
Saito K, Unni K (1999) Osteosarcoma of the jaw bones. Int J Oral Maxillofac Surg 28(Suppl. 1):34
Nachman J, Simon MA, Dean L, Shermeta D, Dawson P, Vogelzang NJ (1987) Disparate histological responses in simultaneously resected primary and metastatic osteosarcoma following intravenous neoadjuvant chemotherapy. J Clin Oncol 5:1185–1190
Wozniak W, Rychlowska M, Liebhart M, Klepacka T, Poznanska A (1993) Preliminary estimation of prognostic factors in osteosarcoma in children on the basis of treatment results. Med Paediatr Oncol 21:596
Smeele LE, van der Wal JE, van Diest PJ, van der Waal I, Snow JB (1994) Radical surgical treatment in craniofacial osteosarcoma gives excellent survival. A retrospective cohort study of 14 patients. Eur J Cancer B Oral Oncol 30:374–376
Van Es RJ, Keus RB, van der Wall I, Koole R, Vermey A (1997) Osteosarcoma of the jaw bones. Long-term follow up of 48 cases. Int J Oral Maxillofac Surg 26:191–197
DeAngelis AF, Spinou C, Tsui A, Iseli T et al (2012) Outcomes of patients with maxillofacial osteosarcoma: a review of 15 cases. J Oral Maxillofac Surg 70:734–739
Baghaie F, Motahhary P (2003) Osteosarcoma of the jaws: a retrospective study. Acta Med Iran 41:113–121
Patel SG, Meyers P, Huvos AG et al (2002) Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer 95:1495–1503
Smith RB, Apostolakis LW, Karnell LH, Koch BB, Robinson RA (2003) National cancer data base report on osteosarcoma of the head and neck. Cancer 98:1670–1680
Ha PK, Eisele DW, Frassica FJ, Zahurak ML, McCarthy EF (1999) Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope 109:964–969
Durnali A, Alkis N, Yukruk FA, Dikmen AU, Akman T et al (2014) Osteosarcoma of the jaws in adult patients: a clinico pathological study of 14 patients. Sarcoma Res Int 1:4
Oda D, Bavisotto LM, Schmidt RA, McNutt M, Bruckner JD, Conrad EU III et al (1997) Head and neck osteosarcoma at the university of Washington. Head Neck 19:513–523
Laskar S, Basu A et al (2009) Osteosarcoma of the head and neck region: lessons learned from a single-institution experience of 50 patients. Head Neck 30:1020–1026
Kassir RR, Rassekh CH, Kinsella JB, Segas J, Carrau RL, Hokanson JA (1997) Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope 107:56–61
Gadwal SR, Gannon FH, Fanburg-Smith JC, Becoskie EM, Thompson LD (2001) Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature. Cancer 91:598–605
Chen Y, Shen Q, Gokavarapu S, Lin C, Yahiya Cao W, Chauhan S, Liu Z, Ji T, Tian Z (2016) Osteosarcoma of head and neck: a retrospective study on prognostic factors from a single institute database. Oral Oncol 58:1–7
Granados-Garcia M, Luna-Ortiz K, Castillo-Oliva HA et al (2006) Free osseous and soft tissue surgical margins as prognostic factors in mandibular osteosarcoma. Oral Oncol 42:172–176
Mendenhall WM, Fernandes R, Werning JW, Vaysberg M, Malyapa RS, Mendenhall NP (2011) Head and neck osteosarcoma. Am J Otolaryngol 32:597–600
Boon E, van der Graaf WT, Gelderblom H, Tesselaar ME, van Es RJ, Oosting SF et al (2017) Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults. Head Neck 39:140–146
Mücke T, Mitchell DA, Tannapfel A, Wolff KD, Loeffelbein DJ, Kanatas A (2014) Effect of neoadjuvant treatment in the management of osteosarcomas of the head and neck. J Cancer Res Clin Oncol 140:127–131
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All procedures performed in this report were in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
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Krishnamurthy, A., Palaniappan, R. Osteosarcomas of the Head and Neck Region: A Case Series with a Review of Literature. J. Maxillofac. Oral Surg. 17, 38–43 (2018). https://doi.org/10.1007/s12663-017-1017-8
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DOI: https://doi.org/10.1007/s12663-017-1017-8