Abstract
Background
Serratiopeptidase for pain, facial swelling and trismus associated with surgical removal of impacted molar is under investigation. However conclusive evidence on the use of serratiopeptidase is lacking. Hence a systematic review and meta-analysis of randomized controlled studies was carried out.
Methods
Electronic databases were searched for eligible studies and necessary data extracted. The data were analysed using non-Cochrane mode in RevMan 5.0. 95% confidence interval (95% CI) was used to represent the deviation from the point estimate. The heterogeneity between the studies was assessed using Forest plot visually, I2 statistics and Chi square test with a statistical P value of <0.10 to indicate statistical significance. Random-effect models were used in case of moderate to severe heterogeneity.
Results
Five studies were included for final review. Serratiopeptidase improved trismus better than corticosteroids with the MD, 95% as 4.42 [3.84, 5]. As regards to swelling, no significant difference was observed for serratiopeptidase when compared to corticosteroids. Paucity of studies precludes any conclusion for other outcome measures as well as for other comparator drugs.
Conclusion
Serratiopeptidase could be used safely and effectively to improve trismus and facial swelling after surgical removal of impacted molar.
Similar content being viewed by others
References
Joshi KK, Nerurkar RP (2012) Anti-inflammatory effect of the serratiopeptidase–rationale or fashionable: a study in rat paw oedema model induced by the carrageenan. Indian J Physiol Pharmacol 56:367–374
Selan L, Papa R, Tilotta M et al (2015) Serratiopeptidase: a well-known metalloprotease with a new non-proteolytic activity against S. aureus biofilm. BMC Microbiol 15:207. doi:10.1186/s12866-015-0548-8
Seymour RA, Blair GS, Wyatt FA (1983) Post-operative dental pain and analgesic efficacy. Part I. Br J Oral Surg 21:290–297
Sannino G, Gigola P, Puttini M et al (2013) Combination therapy including serratiopeptidase improves outcomes of mechanical-antibiotic treatment of periimplantitis. Int J Immunopathol Pharmacol 26:825–831
Passariello C, Lucchese A, Pera F (2012) Clinical, microbiological and inflammatory evidence of the efficacy of combination therapy including serratiopeptidase in the treatment of periimplantitis. Eur J Inflamm 10:463–472
Kastury N, Singh S, Ansari KU (1999) An audit of prescription for rational use of fixed dose drug combinations. Indian J Pharmacol 31:367
Mead SV (1930) Incidence of impacted teeth. Int J Orthodo Oral Surg Radiog 16:885–890
Grover PS, Lorton L (1985) The incidence of unerupted permanent teeth and related clinical cases. Oral Surg Oral Med Oral Pathol 59:420–425
Sisk AL, Hammer WB, Shelton DW (1986) Complications following removal of impacted third molars: the role of the experience of the surgeon. J Oral Maxillofac Surg 44(11):855–859
Fisher SE, Frame JW, Rout PJ et al (1988) Factors affecting the onset and severity of pain following the surgical removal of unilateral impacted mandibular third molar teeth. Br Dent J 164:351–354
Merten HA, Muller K, Drubel F et al (1991) Volumetric verification of edema protection with serrapeptase after third molar osteotomy. Dtsch Z Mund Kiefer Gesichtschir 15:302–305
Bhagat S, Agarwal M, Roy V (2013) Serratiopeptidase: a systematic review of the existing evidence. Int J Surg 11:209–217
Higgins JPT, Green S (editors) Cochrane handbook for systematic reviews of interventions, 5.1.0 edn. www.cochrane-handbook.org. Accessed on 15 Oct 2015
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. J Clin Epidemiol 62:1006–1012
GRADE Working Group (2004) Grading quality of evidence and strength of recommendations. BMJ 328:1490
Chopra D, Rehan HS, Mehra P et al (2009) A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. Int J Oral Maxillofac Surg 38:350–355
Al-Khateeb TH, Nusair Y (2008) Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg 37:264–268
Murugesan K, Sreekumar K, Sabapathy B (2012) Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery. Indian J Dent Res 23:709–713
Chappi DM, Suresh KV, Patil MR et al (2015) Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery. J Clin Exp Dent 7:e197–e202
Kannan R, Kavitha R (2015) A comparative study of anti-inflammatory properties of bromelain/serratiopeptidase as an add on therapy to conventional treatment following impacted third molar surgery. World J Pharm Res 4:2595–2607
Woodley JF (1994) Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Syst 11:61–95
Klein G, Kullich W (2000) Short-term treatment of painful osteoarthritis of the knee with oral enzymes. A randomized, double-blind study versus diclofenac. Clin Drug Invest 19:15–23
Sasaki S, Kawanami R, Motizuki Y et al (2000) Serrapeptase-induced lung injury manifesting as acute eosiniphilic pneumonia. Nihon Kokyuki Gakkai Zasshi 38:540–544 (Japanese)
Mazzone A, Catalani M, Costanzo M et al (1990) Evaluation of Serratia-peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 18:379–388
Acknowledgements
We acknowledge Cochrane reviews for utilizing RevMan software for generating the pooled results and Forest plots.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None of the authors have any conflict of interest.
Rights and permissions
About this article
Cite this article
Sivaramakrishnan, G., Sridharan, K. Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis. J. Maxillofac. Oral Surg. 17, 122–128 (2018). https://doi.org/10.1007/s12663-017-0996-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12663-017-0996-9