Abstract
Pongame oiltree (Millettia pinnata) is one of the medicinal plants that are grown in humid subtropical climate zones. The seeds are the major source of furanoflavonoids karanjin and pongamol that exhibit anticancerous, antimicrobial, antipesticidal, antilarval, anti-oxidant, and anti-inflammatory properties. The seed oil also possesses antimicrobial properties due to the presence of unsaturated fatty acids namely linoleic, oleic, and linolenic acids. However, there is limited understanding of the mechanisms of action of Millettia pinnata seeds bioactive compounds. Thus, the review aims to describe the comprehensive information with special emphasis on seed and seed oil, the phytochemistry of compounds, the detailed pharmacological potential of phytocompounds, and their role in agri-food industries. As well, the bioactivity of seed and seed oil is explained in detail with their bioactive mechanisms. Millettia pinnata seed and seed oil contain a diverse range of phytochemicals, which vary based on factors such as geographic location, climate, and extraction method. The bioactive mechanisms of the phytochemicals in Millettia pinnata seed and seed oil are diverse, with some compounds acting by modulating key enzymes and signaling pathways, while others act by inducing cell death or inhibiting cell proliferation. Millettia pinnata seed and seed oil have potential applications in the agri-food industry, including as food additives and ingredients, and for their potential to improve the shelf life and nutritional value of food products. Overall, the detailed description of the bioactive mechanisms of the phytochemicals in these compounds adds to the current understanding of their potential therapeutic applications. This review explores its diverse phytocompounds, including karanjin and pongamol, known for insecticidal and medicinal properties. The plant’s alkaloids contribute to anti-inflammatory and antimicrobial effects. Pongamia oil has applications in skin care and even cancer treatment, with additional antibacterial and insecticidal benefits. This cost-effective oil finds uses in cosmetics. This review discusses seed composition, therapeutic uses, Ayurvedic applications, and the plant’s role in various activities, from anti-quorum sensing to antioxidation and anti-inflammation. It underscores the plant’s promising future in pharmaceuticals and agriculture.
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Saini, R.K., Sivanesan, I., Keum, Y.S.: Phytochemicals of Moringa oleifera: a review of their nutritional, therapeutic and industrial significance. 3 Biotech (2016). https://doi.org/10.1007/s13205-016-0526-3
Badole, S.L., Zanwar, A.A., Khopade, A.N., Bodhankar, S.L.: In vitro antioxidant and antimicrobial activity cycloart-23-ene-3β,-25-diol (B2) isolated from Pongamia pinnata (L. Pierre). Asian Pac. J. Trop. Med. 4, 910–916 (2011)
Nadeem, F., Inam, S., Rashid, U., Kainat, R., Iftikhar, A.: A review of geographical distribution, phytochemistry, biological properties and potential applications of Pongamia pinatta. Int. J. Chem. Biochem. Sci. 10, 79–86 (2016)
Usharani, K.V., Naik, D., Manjunatha, R.L.: Pongamia pinnata (L.): composition and advantages in agriculture: a review. J. Pharmacogn. Phytochem. 8(3), 2181 (2019)
Rekha, M.J., Bettadaiah, B.K., Sindhu Kanya, T.C., Govindaraju, K.: A feasible method for isolation of pongamol from karanja (Pongamia pinnata) seed and its antiinflammatory activity. Ind. Crops Prod. (2020). https://doi.org/10.1016/j.indcrop.2020.112720
Sharma, A., Kaushik, N., Rathore, H.: Karanja (Millettia pinnata (L.) Panigrahi): a tropical tree with varied applications. Phytochem. Rev. 19(3), 643–658 (2020). https://doi.org/10.1007/s11101-020-09670-z
Venkatraman, P.D., Sayed, U., Parte, S., Korgaonkar, S.: Novel antimicrobial finishing of organic cotton fabrics using nano-emulsions derived from Karanja and Gokhru plants. Text. Res. J. (2022). https://doi.org/10.1177/00405175221113364
Rao, R.R., Chaturvedi, V., Babu, K.S., Reddy, P.P., Rao, V.R.S., Sreekanth, P., Sreedhar, A.S., Madhusudana Rao, J.: Synthesis and anticancer effects of pongamol derivatives on mitogen signaling and cell cycle kinases. Med. Chem. Res. 21(5), 634–641 (2012). https://doi.org/10.1007/s00044-011-9563-y
Jahan, S., Mahmud, M.H., Khan, Z., Alam, A., Khalil, A.A., Rauf, A., Tareq, A.M., Nainu, F., Tareq, S.M., Emran, T.B., Khan, M., Khan, I.N., Wilairatana, P., Mubarak, M.S.: Health promoting benefits of pongamol: an overview. Biomed. Pharmacother. (2021). https://doi.org/10.1016/j.biopha.2021.112109
Degani, E., Prasad, M.V.R., Paradkar, A., Pena, R., Soltangheisi, A., Ullah, I., Warr, B., Tibbett, M.: A critical review of Pongamia pinnata multiple applications: from land remediation and carbon sequestration to socioeconomic benefits. J. Environ. Manag. (2022). https://doi.org/10.1016/j.jenvman.2022.116297
Mitra, S., Ghose, A., Gujre, N., Senthilkumar, S., Borah, P., Paul, A., Rangan, L.: A review on environmental and socioeconomic perspectives of three promising biofuel plants Jatropha curcas, Pongamia pinnata, and Mesua ferrea. Biomass Bioenergy (2021). https://doi.org/10.1016/j.biombioe.2021.106173
Suryawanshi, B., Mohanty, B.: Modeling and optimization: supercritical CO2 extraction of Pongamia pinnata (L.) seed oil. J. Environ. Chem. Eng. 6(2), 2660–2673 (2018). https://doi.org/10.1016/j.jece.2018.04.014
Shadangi, K.P., Mohanty, K.: Thermal and catalytic pyrolysis of Karanja seed to produce liquid fuel. Fuel 115, 434–442 (2014). https://doi.org/10.1016/j.fuel.2013.07.053
Singh, A., Bhatt, G., Gujre, N., Mitra, S., Swaminathan, R., Limaye, A.M., Rangan, L.: Karanjin. Phytochemistry (2021). https://doi.org/10.1016/j.phytochem.2020.112641
Plaola, Y., Leangsiri, W., Pongsiriyakul, K., Kiatkittipong, W., Srifa, A., Lim, J.W., Reubroycharoen, P., Kiatkittipong, K., Eiad-Ua, A., Assabumrungrat, S.: Catalytic hydrotreating of crude Pongamia pinnata oil to bio-hydrogenated diesel over sulfided NiMo catalyst. Energies (2022). https://doi.org/10.3390/en15041547
Bora, M.M., Deka, R., Ahmed, N., Kakati, D.K.: Karanja (Millettia pinnata (L.) Panigrahi) seed oil as a renewable raw material for the synthesis of alkyd resin. Ind. Crops Prod. 61, 106–114 (2014). https://doi.org/10.1016/j.indcrop.2014.06.048
Marone, P.A., Olson, J., Matulka, R., Bauter, M., Astwood, J.D.: Safety and toxicologic evaluation of edible Pongamia oil: a novel food ingredient. Food Chem. Toxicol. (2022). https://doi.org/10.1016/j.fct.2022.113213
Abbasi, M.S.A., Tahir, M.A.: Spectroscopic analysis of flavonoids isolated from Pongamia pinnata L. seed oil. Asian J. Chem. Sci. (2020). https://doi.org/10.9734/ajocs/2020/v7i419027
Sajid, Z.I., Anwar, F., Shabir, G., Rasul, G., Alkharfy, K.M., Gilani, A.H.: Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. Molecules 17(4), 3917–3932 (2012). https://doi.org/10.3390/molecules17043917
Verma, M., Pradhan, S., Sharma, S., Naik, S.N., Prasad, R.: Efficacy of karanjin and phorbol ester fraction against termites (Odontotermes obesus). Int. Biodeterior. Biodegrad. 65(6), 877–882 (2011). https://doi.org/10.1016/j.ibiod.2011.05.007
Purkait, A., Mukherjee, A., Hazra, D.K., Roy, K., Biswas, P.K., Kole, R.K.: Encapsulation, release and insecticidal activity of Pongamia pinnata (L.) seed oil. Heliyon (2021). https://doi.org/10.1016/j.heliyon.2021.e06557
Raghav, D., Mahanty, S., Rathinasamy, K.: Biochemical and toxicological investigation of karanjin, a bio-pesticide isolated from Pongamia seed oil. Pestic. Biochem. Physiol. 157, 108–121 (2019). https://doi.org/10.1016/j.pestbp.2019.03.011
Rajput, M., Bithel, N., Vijayakumar, S.: Antimicrobial, antibiofilm, antioxidant, anticancer, and phytochemical composition of the seed extract of Pongamia pinnata. Arch. Microbiol. 203(7), 4005–4024 (2021). https://doi.org/10.1007/s00203-021-02365-9
Al Muqarrabun, L.M.R., Ahmat, N., Ruzaina, S.A.S., Ismail, N.H., Sahidin, I.: Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata (L.) Pierre: a review. J. Ethnopharmacol. 150(2), 395–420 (2013). https://doi.org/10.1016/j.jep.2013.08.041
Sree, R., Rao, R., Gulshan Md, S.A., Prasanna, L.: Pongamia: assemble of natural wealth. Indo Am. J. Pharm. Res. 4(9), 3642–3653 (2014)
Alibi, S., ben Selma, W.B., Ramos-Vivas, J., Smach, M.A., Touati, R., Boukadida, J., Navas, J., ben Mansour, J.H.: Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates. Curr. Res. Transl. Med. 68(2), 59–66 (2020). https://doi.org/10.1016/j.retram.2020.01.001
Chaudhari, V., Gosai, H., Raval, S., Kothari, V.: Effect of certain natural products and organic solvents on quorum sensing in Chromobacterium violaceum. Asian Pac. J. Trop. Med. 7(S1), S204–S211 (2014). https://doi.org/10.1016/S1995-7645(14)60233-9
Jansen, K.U., Gruber, W.C., Simon, R., Wassil, J., Anderson, A.S.: The impact of human vaccines on bacterial antimicrobial resistance. A review. Environ. Chem. Lett. 19(6), 4031–4062 (2021). https://doi.org/10.1007/s10311-021-01274-z
Kesari, V., Das, A., Rangan, L.: Physico-chemical characterization and antimicrobial activity from seed oil of Pongamia pinnata, a potential biofuel crop. Biomass Bioenergy 34(1), 108–115 (2010). https://doi.org/10.1016/j.biombioe.2009.10.006
Malaikozhundan, B., Vaseeharan, B., Vijayakumar, S., Pandiselvi, K., Kalanjiam, M.A.R., Murugan, K., Benelli, G.: Biological therapeutics of Pongamia pinnata coated zinc oxide nanoparticles against clinically important pathogenic bacteria, fungi and MCF-7 breast cancer cells. Microb. Pathog. 104, 268–277 (2017). https://doi.org/10.1016/j.micpath.2017.01.029
Peixoto, L.R., Rosalen, P.L., Ferreira, G.L.S., Freires, I.A., de Carvalho, F.G., Castellano, L.R., de Castro, R.D.: Antifungal activity, mode of action and anti-biofilm effects of Laurus nobilis Linnaeus essential oil against Candida spp. Arch. Oral Biol. 73, 179–185 (2017). https://doi.org/10.1016/j.archoralbio.2016.10.013
Benamar-Aissa, B., Gourine, N., Ouinten, M., Harrat, M., Benarfa, A., Yousfi, M.: Synergistic effects of essential oils and phenolic extracts on antioxidant activities responses using two Artemisia species (A. campestris and A. herba alba) combined with Citrus aurantium. Biocatal. Agric. Biotechnol. 47, 102570 (2023). https://doi.org/10.1016/j.bcab.2022.102570
Roy, R., Pal, D., Sur, S., Mandal, S., Saha, P., Panda, C.K.: Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa-light-chain-enhancer of activated B cell signaling. Phytother. Res. 33(4), 1084–1094 (2019). https://doi.org/10.1002/ptr.6302
Vadivel, V., Biesalski, H.K.: Contribution of phenolic compounds to the antioxidant potential and type II diabetes related enzyme inhibition properties of Pongamia pinnata L. Pierre seeds. Process Biochem. 46(10), 1973–1980 (2011). https://doi.org/10.1016/j.procbio.2011.07.007
Ghosh, A., Tiwari, G.J.: Role of nitric oxide-scavenging activity of Karanjin and Pongapin in the treatment of Psoriasis. 3 Biotech (2018). https://doi.org/10.1007/s13205-018-1337-5
Rekha, M.J., Bettadaiah, B.K., Muthukumar, S.P., Govindaraju, K.: Synthesis, characterization and anti-inflammatory properties of karanjin (Pongamia pinnata seed) and its derivatives. Bioorg. Chem. (2021). https://doi.org/10.1016/j.bioorg.2020.104471
Dinda, B., Dinda, S., DasSharma, S., Banik, R., Chakraborty, A., Dinda, M.: Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. Eur. J. Med. Chem. 131, 68–80 (2017). https://doi.org/10.1016/j.ejmech.2017.03.004
Wojcieszyńska, D., Guzik, H., Guzik, U.: Non-steroidal anti-inflammatory drugs in the era of the Covid-19 pandemic in the context of the human and the environment. Sci. Total. Environ. (2022). https://doi.org/10.1016/j.scitotenv.2022.155317
Gong, Y., Huang, X., Chen, M., & Xiong, L.: Teprenone improves gastric mucosal injury and dyspeptic symptoms in long term nonsteroidal anti-inflammatory drug users. J. Gastroenterol. Hepatol. 34, 1344–1350 (2019). https://doi.org/10.1111/jgh.14614
Vismaya, Belagihally, S.M., Rajashekhar, S., Jayaram, V.B., Dharmesh, S.M., Thirumakudalu, S.K.C.: Gastroprotective properties of karanjin from Karanja (Pongamia pinnata) seeds; Role as antioxidant and H+, K+-ATPase inhibitor. Evid. Based Complement. Altern. Med. (2011). https://doi.org/10.1093/ecam/neq027
Patel, P.P., Trivedi, N.D.: Effect of karanjin on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in Balb/c mice. Indian J. Pharmacol. 49(2), 161–167 (2017). https://doi.org/10.4103/ijp.IJP_234_15
Saini, P., Lakshmayya, L., Bisht, V.: Anti-Alzheimer activity of isolated karanjin from Pongamia pinnata (L.) Pierre and embelin from Embelia ribes Burm. F. AYU. Int. Q. J. Res. Ayurveda 38(1), 76 (2017). https://doi.org/10.4103/ayu.ayu_174_16
Bhatt, G., Gupta, A., Rangan, L., Mukund Limaye, A.: Global transcriptome analysis reveals partial estrogen-like effects of karanjin in MCF-7 breast cancer cells. Gene (2022). https://doi.org/10.1016/j.gene.2022.146507
Bose, M., Chakraborty, M., Bhattacharya, S., Bhattacharjee, P., Mandal, S., Kar, M., Mishra, R.: Suppression of NF-κB p65 nuclear translocation and tumor necrosis factor-α by Pongamia pinnata seed extract in adjuvant-induced arthritis. J. Immunotoxicol. 11(3), 222–230 (2014). https://doi.org/10.3109/1547691X.2013.824931
Bose, M., Chakraborty, M., Bhattacharya, S., Mukherjee, D., Mandal, S., Mishra, R.: Prevention of arthritis markers in experimental animal and inflammation signalling in macrophage by karanjin isolated from Pongamia pinnata seed extract. Phytother. Res. 28(8), 1188–1195 (2014). https://doi.org/10.1002/ptr.5113
Elakkiya, V., Krishnan, K., Bhattacharyya, A., Selvakumar, R.: Advances in Ayurvedic medicinal plants and nanocarriers for arthritis treatment and management: a review. J. Herb. Med. (2020). https://doi.org/10.1016/j.hermed.2020.100412
Dwivedi, G., Sharma, M.P.: Prospects of biodiesel from Pongamia in India. Renew. Sustain. Energy Rev. 32, 114–122 (2014). https://doi.org/10.1016/j.rser.2014.01.009
Baiju, B., Naik, M.K., Das, L.M.: A comparative evaluation of compression ignition engine characteristics using methyl and ethyl esters of Karanja oil. Renew. Energy 34(6), 1616–1621 (2009). https://doi.org/10.1016/j.renene.2008.11.020
Jaya, N., Selvan, B.K., Vennison, S.J.: Synthesis of biodiesel from pongamia oil using heterogeneous ion-exchange resin catalyst. Ecotoxicol. Environ. Saf. 121, 3–9 (2015). https://doi.org/10.1016/j.ecoenv.2015.07.035
Kumar, R., Ravi Kumar, G., Chandrashekar, N.: Microwave assisted alkalicatalyzed transesterification of Pongamia pinnata seed oil for biodiesel production. Bioresour. Technol. 102(11), 6617–6620 (2011). https://doi.org/10.1016/j.biortech.2011.03.024
Khayoon, M.S., Olutoye, M.A., Hameed, B.H.: Utilization of crude karanj (Pongamia pinnata) oil as a potential feedstock for the synthesis of fatty acid methyl esters. Bioresour. Technol. 111, 175–179 (2012). https://doi.org/10.1016/j.biortech.2012.01.177
Muktham, R., Ball, A.S., Bhargava, S.K., Bankupalli, S.: Bioethanol production from non-edible de-oiled Pongamia pinnata seed residue-optimization of acid hydrolysis followed by fermentation. Ind. Crops Prod. 94, 490–497 (2016). https://doi.org/10.1016/j.indcrop.2016.09.019
Obadiah, A., Kannan, R., Ramasubbu, A., Kumar, S.V.: Studies on the effect of antioxidants on the long-term storage and oxidation stability of Pongamia pinnata (L.) Pierre biodiesel. Fuel Process. Technol. 99, 56–63 (2012). https://doi.org/10.1016/j.fuproc.2012.01.032
Rawat, D.S., Joshi, G., Lamba, B.Y., Tiwari, A.K., Mallick, S.: Impact of additives on storage stability of Karanja (Pongamia pinnata) biodiesel blends with conventional diesel sold at retail outlets. Fuel 120, 30–37 (2014). https://doi.org/10.1016/j.fuel.2013.12.010
Bajpai, S., Sahoo, P.K., Das, L.M.: Feasibility of blending karanja vegetable oil in petro-diesel and utilization in a direct injection diesel engine. Fuel 88(4), 705–711 (2009). https://doi.org/10.1016/j.fuel.2008.09.011
Agarwal, A.K., Dhar, A.: Experimental investigations of performance, emission and combustion characteristics of Karanja oil blends fuelled DICI engine. Renew. Energy 52, 283–291 (2013). https://doi.org/10.1016/j.renene.2012.10.015
Agarwal, A.K., Dhar, A.: Experimental investigations of performance, emission and combustion characteristics of Karanja oil blends fuelled DICI engine. Renew. Energy 52, 283–291 (2013)
Kumar, R., Pal, P.: Lipase immobilized graphene oxide biocatalyst assisted enzymatic transesterification of Pongamia pinnata (Karanja) oil and downstream enrichment of biodiesel by solar-driven direct contact membrane distillation followed by ultrafiltration. Fuel Process. Technol. 211, 106577 (2021). https://doi.org/10.1016/j.fuproc.2020.106577
Perumalsamy, H., Jang, M.J., Kim, J.R., Kadarkarai, M., Ahn, Y.J.: Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. Parasit. Vectors (2015). https://doi.org/10.1186/s13071-015-0848-8
Sahayaraj, K., Madasamy, M., Anbu Radhika, S.: Insecticidal activity of biosilver and gold nanoparticles against Pericallia ricini Fab. (Lepidaptera: Archidae). J. Biopestic. 9(1), 63–72 (2016)
Gabriel Paulraj, M., Ignacimuthu, S., Gandhi, M.R., Shajahan, A., Ganesan, P., Packiam, S.M., Al-Dhabi, N.A.: Comparative studies of tripolyphosphate and glutaraldehyde cross-linked chitosan-botanical pesticide nanoparticles and their agricultural applications. Int. J. Biol. Macromol. 104, 1813–1819 (2017). https://doi.org/10.1016/j.ijbiomac.2017.06.043
Singha, K., Sreeharsha, R., Mariboina, S., Reddy, A.: Dynamics of metabolites and key regulatory proteins in the developing seeds of Pongamia pinnata, a potential biofuel tree species. Ind. Crops Prod. 140, 111621 (2019). https://doi.org/10.1016/j.indcrop.2019.111621
Siroha, A., Punia, S., Kaur, M., Sandhu, K.: A novel starch from Pongamia pinnata seeds: comparison of its thermal, morphological and rheological behaviour with starches from other botanical sources. Int. J. Biol. Macromol. (2019). https://doi.org/10.1016/j.ijbiomac.2019.10.033
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Devidas, T.B., Vyas, A., Sridhar, K. et al. Valorization of Pongame Oiltree (Millettia pinnata) Seed and Seed Oil: A Promising Source of Phytochemicals and Its Applications. Waste Biomass Valor (2023). https://doi.org/10.1007/s12649-023-02352-9
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DOI: https://doi.org/10.1007/s12649-023-02352-9