Abstract
Viola odorata essential oil has been used as an anticancer compound for its salubrious ingredients. Their bioactive components can be protected and made more accessible through triggering nanotechnology methods. The current study aimed to produce V. odorata essential oil nanoemulsions as a drug delivery system for the first time, as well as assessing its apoptotic effect on A2780 cells and anti-angiogenic potentials. In this regard, the nanoemulsions were synthesized through employing the ultrasound-based nanoemulsification approach and characterized by using TEM, DLS, and zeta potential. Then, supplementary tests were implemented to verify their cytotoxic, apoptotic, and anti-angiogenic properties. In general, the results represented that 50.98-nm VEO-NE significantly decreased the viability of the A2780 ovarian cancer cells compared to the HFF normal cells and induced apoptotic response. Additionally, the results were further confirmed by the upregulation of caspase-3, and downregulation of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) genes. Thus, the prepared nanoemulsions can be utilized as a safe cell-selective anticancer drug delivery system and may be a promising compound for enriched foods in the food industry.
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Sahib Abed, H., Zarearki, P., Khojasteh, V. et al. Inhibition the Growth of Human Ovarian Cancer Cells (A2780) via Cell Proliferation and Angiogenesis by Viola odorata Essential Oil Nanoemulsion. Waste Biomass Valor 15, 2417–2426 (2024). https://doi.org/10.1007/s12649-023-02314-1
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DOI: https://doi.org/10.1007/s12649-023-02314-1