Abstract
Elevated serum uric acid (SUA) has been reported to be associated with an increased risk of cardiovascular diseases, but the role of SUA in intracranial atherosclerosis remains unclear. To investigate the association between SUA and intracranial atherosclerotic stenosis (ICAS), we evaluated 1522 subjects (305 with ICAS, 1217 without ICAS) with magnetic resonance angiography (MRA). Subjects were classified into ten groups according to the deciles of the SUA level. The rate of ICAS reached a minimum in the seventh decile (6.0–6.3 mg/dL; reference group). After adjusting for confounding factors, multivariate logistic regression analysis demonstrated that both low SUA level (≤ 3.8 mg/dL; OR, 2.34; 95% CI, 1.29–4.39; p = 0.006) and high SUA level (≥ 7.8 mg/dL; OR, 2.10; 95% CI, 1.15–3.92; p = 0.017) conferred greater risk for ICAS. In multivariable analysis with a quadratic model which used SUA as a continuous variable, a U-shaped association between SUA and the rate of ICAS was confirmed (α > 0; p < 0.001). The estimated SUA level associated with the lowest rate of ICAS was 6.2 mg/dL. In conclusion, our findings suggest a U-shaped association between ICAS and SUA.
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Abbreviations
- SUA:
-
serum uric acid
- ICAS:
-
intracranial atherosclerotic stenosis
- MRA:
-
magnetic resonance angiography
- MSU:
-
monosodium urate
- NHANES:
-
National Health and Nutrition Examination Survey
- ICA:
-
internal carotid artery
- MCA:
-
middle cerebral artery
- ACA:
-
anterior cerebral artery
- PCA:
-
posterior cerebral artery
- VA:
-
vertebral artery
- BA:
-
basilar artery
- CHD:
-
coronary heart disease
- HDL:
-
High-density lipoprotein
- LDL:
-
low-density lipoprotein
- BUN:
-
blood urea nitrogen
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We thank all the study participants for their assistants and supports.
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This work was supported by grants from the Taishan Scholars Program of Shandong Province (ts201511109 and tsqn20161079) and Qingdao Key Health Discipline Development Fund, Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01) and ZHANGJIANG LAB, Tianqiao and Chrissy Chen Institute, and the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Fudan University.
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JTY, LT, and QD conceptualized the study, analyzed and interpreted the data, and drafted and revised the manuscript. LL, YAS, and XHH analyzed and interpreted the data, drafted and revised the manuscript, did the statistical analysis, and prepared all the figures. YHM, WX, CCT, FRS, and HQL contributed to interpretation of the data and revision of the manuscript. All authors contributed to the writing and revisions of the paper and approved the final version.
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Written informed consent form was obtained from all participants or their guardians. This study was approved by the Institutional Ethics Committees of Qingdao Municipal Hospital.
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Li, L., Zhu, JX., Hou, XH. et al. Serum Uric Acid Levels and Risk of Intracranial Atherosclerotic Stenosis: A Cross-Sectional Study. Neurotox Res 37, 936–943 (2020). https://doi.org/10.1007/s12640-020-00171-7
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DOI: https://doi.org/10.1007/s12640-020-00171-7