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Paget’s Disease of the Breast: a Review of Clinical Management

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Abstract

Summary

Paget’s disease of the breast (PDB) is a rare breast neoplasm that presents as eczematous changes near the nipple that is often associated with underlying malignancy.

Recent Findings

The pathogenesis of Paget’s disease of the breast is debated to either originate from malignant ductal epithelial cells, transformation in situ, or both. Tissue biopsy is the hallmark for diagnosis in order to avoid misdiagnosis and ensure prompt treatment. Imaging modalities such as mammogram, ultrasound, and magnetic resonance imaging are used to ascertain if there is a concurrent underlying carcinoma. Treatment options resemble that of an invasive breast cancer and consist of mastectomy or breast conservation therapy including central segmentectomy with radiation therapy.

Purpose of Review

This review will discuss the epidemiology, pathogenesis, clinical presentation, diagnosis, and the various available treatment modalities. The aim of this review is to provide an overview of this rare entity in order to better recognize and clinically manage it.

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Funding

The project described was supported in part by award number P30CA014089 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

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Authors and Affiliations

  1. Norris Comprehensive Cancer Center, Los Angeles, CA, USA

    Denaly Chen

  2. Department of Medicine, University of Southern California Medical Center, Los Angeles, CA, USA

    Denaly Chen

  3. Department of Surgery, University of Southern California, Los Angeles, CA, USA

    Yue Zhu & Joseph Carey

  4. Division of Breast Services, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    Moustafa Moussally & Julie E. Lang

  5. Department of Pathology, University of Southern California, Los Angeles, CA, USA

    Sergei Tatishchev

  6. Department of Surgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA

    Kirstyn E. Brownson

  7. Department of Radiology, University of Southern California, Los Angeles, CA, USA

    Catherine Evans & Pulin Sheth

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  1. Denaly Chen
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Chen, D., Zhu, Y., Moussally, M. et al. Paget’s Disease of the Breast: a Review of Clinical Management. Curr Breast Cancer Rep 15, 379–387 (2023). https://doi.org/10.1007/s12609-023-00509-y

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