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Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats

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Abstract

Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC). Offering 20 g/day of Minas cheese with Lact. acidophilus La-05 (108–109 log CFU/g) for 6 weeks. The cardiomyocyte diameter was determined. Superoxide dismutase (SOD) activity in plasma, heart, kidney, and colon tissue was performed. At the end of supplementation, no significant changes in lipid profile and renal parameters were found. The NxPC group showed a decrease in cardiomyocyte diameter compared to the NxC group (16.99 ± 0.85 vs. 19.05 ± 0.56 μm, p = 0.0162); also they showed reduced plasmatic SOD activity (502.8 ± 49.12 vs. 599.4 ± 94.69 U/mL, p < 0.0001). In summary, probiotic-enriched Minas cheese (Lact. acidophilus La-05) consumption suggests a promisor cardioprotective effect and was able to downregulate SOD activity in a rat model of CKD.

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Data Availability

The data that support the findings of this study are available from the corresponding author, Silva Costa N and Araujo JR, upon reasonable request.

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Acknowledgements

We are thankful to the following laboratories for their technical assistance: Experimental Nutrition Laboratory (LabNE)- Fluminense Federal University for allowing the use of animal houses, Unidade de Pesquisa Clínica (UPC) to assist in the use of equipment, and Multi-user Physiology and Pharmacology Laboratory (LAMFFA), including the use of ChemiDoc MP. The authors would also like to express their thanks to all the collaborators involved in the routine activities of the laboratories.

Funding

The Brazilian foundations supported this project and scholarships: The State of Rio de Janeiro Carlos Chagas Filho Research Foundation (FAPERJ) (Process E-26/201.373/2021), National Counsel of Technological and Scientific Development (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Finance Code 001.

Author information

Author notes

  1. Nathalia da Silva Costa and Joana Ramos de Araujo contributed equally to this study.

Authors and Affiliations

  1. Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Nathalia da Silva Costa, Karen Salve Coutinho-Wolino, Beatriz Oliveira Da Cruz & Milena Barcza Stockler-Pinto

  2. Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Joana Ramos de Araujo, Denise Mafra & Milena Barcza Stockler-Pinto

  3. Nutrition Faculty, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Manuela Fernandes da Silva Melo, Jéssica da Costa Mota & Milena Barcza Stockler-Pinto

  4. Graduate Program in Pathology, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Patricia Pereira Almeida, Michele Lima Brito, Emanuelle Barreto-Reis, Beatriz Gouvêa de Luca, D.’Angelo Carlo Magliano & Milena Barcza Stockler-Pinto

  5. Research Center on Morphology and Metabolism, Biomedical Institute, Fluminense Federal University, Niteroi, RJ, Brazil

    Thaís de Souza Carvalho, Emanuelle Barreto-Reis, Beatriz Gouvêa de Luca & D.’Angelo Carlo Magliano

  6. Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Denise Mafra

  7. Morphology Department, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Renato de Souza Abboud

  8. Veterinary Hygiene and Technical Processing of Animal Products Post Graduate Program, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Ramon Silva Rocha & Adriano Gomes da Cruz

  9. Food Department, Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, RJ, Brazil

    Adriano Gomes da Cruz

  10. Food Technology Department, Veterinary College, Fluminense Federal University (UFF), Niterói, RJ, Brazil

    Jonas de Toledo Guimarães

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  1. Nathalia da Silva Costa
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Contributions

Nathalia da Silva Costa: Formal analysis, Investigation, Data curation, Writing – original draft, Writing – review & editing, Visualization; Joana Ramos de Araujo: Formal analysis, Investigation, Data curation, Writing – original draft, Writing – review & editing, Visualization; Manuela Fernandes da Silva Melo: Formal analysis, Investigation, Writing – review & editing; Jéssica da Costa Mota: Formal analysis, Investigation, Writing – review & editing; Patrícia Pereira de Almeida: Formal analysis, Data curation, Writing – review & editing; Karen Salve Coutinho-Wolino: Investigation, Writing – review & editing; Beatriz Oliveira Da Cruz: Investigation, Data curation, Writing – review & editing; Michele Brito Lima: Investigation, Writing – review & editing; Thaís de Souza Carvalho: Investigation, Writing – review & editing; Emanuelle Barreto-Reis: Investigation, Writing – review & editing; Beatriz Gouvêa de Luca: Investigation, Writing – review & editing; Denise Mafra: Resources, Writing – review & editing; D’Angelo Carlo Magliano Resources, Writing – review & editing; Renato de Souza Abboud: Resources, Writing – review & editing; Ramon Silva Rocha: Resources, Writing – review & editing; Adriano Gomes da Cruz: Methodology, Resources, Writing – review & editing; Jonas de Toledo Guimarães: Methodology, Data curation, Writing – review & editing; Milena Barcza Stockler-Pinto: Conceptualization, Methodology, Resources, Data curation, Writing – review & editing, Supervision, Project administration, Funding acquisition.

Corresponding authors

Correspondence to Nathalia da Silva Costa or Joana Ramos de Araujo.

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da Silva Costa, N., de Araujo, J.R., da Silva Melo, M.F. et al. Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats. Probiotics & Antimicro. Prot. (2023). https://doi.org/10.1007/s12602-023-10173-4

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