Abstract
Structural reinvestigation of corticatic acid A from a marine sponge, Petrosia sp., resulted in the revision of its structure, which conformed to the structural features of the biosynthetically related linear acetylenes isolated from Petrosia sp. In the process of isolating an authentic corticatic acid A, we isolated three new congeners and determined their structures. We also suggested that the structures of other corticatic acids need revision.
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Acknowledgments
This work was partly supported by a Grant-in-Aid for Scientific Research on Innovative Areas “Chemical Biology of Natural Products” and JSPS KAKENHI Grant Numbers 25252037, 25712024, and 25660163 from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
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Supplementary material 1 (PDF 1081 kb). Electronic Supplementary Material Available: 1H NMR, 2D NMR, and FABMS data for corticatic acids and corticatynol. These materials are published in the online version
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Takada, K., Okada, S. & Matsunaga, S. Structural reappraisal of corticatic acids, biologically active linear polyacetylenes, from a marine sponge of the genus Petrosia . Fish Sci 80, 1057–1064 (2014). https://doi.org/10.1007/s12562-014-0776-0
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DOI: https://doi.org/10.1007/s12562-014-0776-0