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A challenging peripheral T-cell lymphoma of the spleen with fatal outcome: A Tunisian case

Un lymphome T périphérique de la rate fatal de diagnostic difficile : à propos d’un cas tunisien

  • Case Report / Cas Clinique
  • Published:
Journal Africain du Cancer / African Journal of Cancer

Abstract

We report an uncommon case of a 54-year-old woman with unique splenic localization of peripheral T-cell lymphoma-Not otherwise specified (PTCL-NOS). The diagnosis was made after histological, immunohistochemical and cytogenetic study of splenectomy specimens. PTCL-NOS represent a heterogeneous group of nodal and extranodal mature T-cell lymphoma characterized by an aggressive behavior and widespread involvement.

Résumé

Nous rapportons un cas rare de localisation splénique d’un lymphome T périphérique sans autres spécification (PTCL-NOS) survenant chez une femme âgée de 54 ans. Le diagnostic positif a été fait après étude histologique, immunohistochimique et cytogénétique de la pièce de splénectomie. Les PTCL-NOS représentent un groupe hétérogène de lymphomes T matures ganglionnaires et extra-ganglionnaires caractérisé par un comportement agressif et une large dissémination.

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References

  1. Savage KJ, Ferreri AJM, Zinzani PL, Pileri SA (2011) Peripheral T-cell lymphoma — Not otherwise specified. Crit Rev Oncol/Hematol 79: 321–9

    Article  Google Scholar 

  2. Rizvi MA, Evens AM, Tallman MS, et al (2006) T-cell non- Hodgkin lymphoma. Blood 107(4): 1255–64

    Article  CAS  PubMed  Google Scholar 

  3. Lennert K (1978). Malignant lymphomas: other than Hodgkin’s disease: histology, cytology, ultrastructure, immunology. Berlin: Springer-Verlag

    Google Scholar 

  4. Swerdlow SH, Campo E, Harris NL, et al (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press

    Google Scholar 

  5. Campo E, Gaulard P, Zucca E, et al (1998) Report of the European task force on lymphomas: workshop on peripheral T-cell lymphomas. Ann Oncol 9: 835–43

    Article  CAS  PubMed  Google Scholar 

  6. Falini B, Pileri S, De Solas I, et al (1990) Peripheral T-cell lymphoma associated with hemophagocytic syndrome. Blood 75: 434–44

    CAS  PubMed  Google Scholar 

  7. Chan JK. (2003) Splenic involvement by peripheral T-cell and NK-cell neoplasms. Semin Diagn Pathol 20: 105–20

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of pathology, Rabta hospital, Tunis, Tunisia

    S. Attafi, A. Zhani, I. Chelly, H. Azouz, W. Rekik, S. Haouet & N. Kchir

Authors
  1. S. Attafi
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  2. A. Zhani
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  3. I. Chelly
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  4. H. Azouz
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  5. W. Rekik
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  6. S. Haouet
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  7. N. Kchir
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Corresponding author

Correspondence to S. Attafi.

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Attafi, S., Zhani, A., Chelly, I. et al. A challenging peripheral T-cell lymphoma of the spleen with fatal outcome: A Tunisian case. J Afr Cancer 7, 149–152 (2015). https://doi.org/10.1007/s12558-015-0373-x

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  • DOI: https://doi.org/10.1007/s12558-015-0373-x

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