Abstract
Almost seventy years after its discovery, the sodium–potassium adenosine triphosphatase (the sodium pump) located in the cell plasma membrane remains a source of novel mechanistic and physiologic findings. A noteworthy feature of this enzyme/transporter is its robust stoichiometric ratio under physiological conditions: it sequentially counter-transports three sodium ions and two potassium ions against their electrochemical potential gradients per each hydrolyzed ATP molecule. Here we summarize some present knowledge about the sodium pump and its physiological roles, and speculate whether energetic constraints may have played a role in the evolutionary selection of its characteristic stoichiometric ratio.
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References
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Acknowledgements
Fruitful discussions with Dr. Silvia Chifflet are gratefully acknowledged. The authors are established investigators from the Program for the Development of the Basic Sciences (PEDECIBA, Ministerio de Educación y Cultura, Uruguay) and the Uruguayan National Agency for Research and Innovation (ANII).
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Peluffo, R.D., Hernández, J.A. The Na+,K+-ATPase and its stoichiometric ratio: some thermodynamic speculations. Biophys Rev 15, 539–552 (2023). https://doi.org/10.1007/s12551-023-01082-5
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DOI: https://doi.org/10.1007/s12551-023-01082-5