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Effects of a Titanium Dioxide Thin Film for Improving the Biocompatibility of Diamond-Like Coated Coronary Stents

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Abstract

This study was performed to evaluate the effects of a diamond-like carbon (DLC) layer on the biological properties of a pre-treated titanium dioxide (TiO2) coronary stent surface. TiO2 and DLC were coated onto a cobalt-chromium stent surface in consecutive order using the plasma-enhanced chemical vapor deposition method (TiO2/DLC). To investigate the effect of TiO2, a group treated only with DLC was also prepared as a control. The surface characteristics were investigated by SEM, ESCA, AFM, and contact angle analyses. To estimate the effect of surface modification on biological response, endothelial cell migration was carried out. As a result, cracking of the coating layer on the strut curved portion in the DLC group was restored in the TiO2/DLC group. ESCA result showed that the peaks sp2 and sp3 were slightly shifted and higher in the TiO2/DLC group. The surface roughness average was highly increased in the TiO2/DLC group (Ra; 18.033) compared to the BMS (Ra; 9.258) and DLC groups (Ra; 10.144). By the increment of Ra, the surface property became hydrophilic in the TiO2/DLC group (39.8° ± 5.88°) compared to the non-treated (72.7° ± 2.24°) and DLC (78.6° ± 2.24°) groups. Endothelial cell migration was significantly increased in the TiO2/DLC group (68.9 ± 13.52%) compared to the non-treated (5.4 ± 3.14%) and DLC groups (22.3 ± 8.22%). Therefore, the improvement of surface properties and endothelial cell migration in the TiO2/DLC group could improve the physiological response in the human body.

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References

  1. J. Aoki, Intern. Med. 54, 549 (2015)

    Article  Google Scholar 

  2. S.K. Yazdani, M. Vorpahl, M. Nakano, S.H. Su, F.D. Kolodgie, R. Virmani, EuroIntervention 7, 835 (2011)

    Article  Google Scholar 

  3. M.C. Chen, Y. Chang, C.T. Liu, W.Y. Lai, S.F. Peng, Y.W. Hung, H.W. Tsai, H.W. Sung, Biomaterials 30, 79 (2009)

    Article  CAS  Google Scholar 

  4. A.V. Finn, G. Nakazawa, M. Joner, F.D. Kolodgie, E.K. Mont, H.K. Gold, R. Virmani, Arterioscl. Thromb. Vasc. Biol. 27, 1500 (2007)

    Article  CAS  Google Scholar 

  5. P.K. Bowen, E.R. Shearier, S. Zhao, R.J. Guillory 2nd, F. Zhao, J. Goldman, J.W. Drelich, Adv. Healthc. Mater. 5, 1121 (2016)

    Article  CAS  Google Scholar 

  6. T. Hanawa, Adv. Powder. Technol. 3, 289 (2002)

    CAS  Google Scholar 

  7. M.T. Lam, J.C. Wu, Expert. Rev. Cardiovasc. Ther. 10, 1039 (2012)

    Article  CAS  Google Scholar 

  8. W.J. Ma, A.J. Ruys, R.S. Mason, P.J. Martin, A. Bendavid, Z. Liu, M. Ionescu, H. Zreiqat, Biomaterials 28, 1620 (2007)

    Article  CAS  Google Scholar 

  9. R.K. Roy, K.R. Lee, J. Biomed. Mater. Res. B. Appl. Biomater. 83, 72 (2007)

    Article  Google Scholar 

  10. Y. Fu, H. Du, C.Q. Sun, Thin Solid Films 424, 107 (2003)

    Article  CAS  Google Scholar 

  11. D.S. Sim, M.H. Jeong, D.S. Park, J.H. Kim, K.S. Lim, I.H. Bae, P. Zhehao, H.Y. Yang, J.H. Lee, D.Y. Hyun, Y.J. Hong, Y. Ahn, J.C. Kang, Int. J. Cardiol. 222, 436 (2016)

    Article  Google Scholar 

  12. D.S. Park, I.H. Bae, M.H. Jeong, K.S. Lim, D.S. Sim, Y.J. Hong, S.Y. Lee, E.J. Jang, J.W. Shim, J.K. Park, H.C. Lim, H.B. Kim, Mater. Sci. Eng. C Mater. Biol. Appl. 91, 615 (2018)

    Article  CAS  Google Scholar 

  13. J.S. Kwon, S.J. Song, E.J. Yang, Y.S. Kim, K.S. Lim, D.G. Kim, D.L. Cho, M.H. Jeong, Y. Ahn, Int. J. Cardiol. 168, 5104 (2013)

    Article  Google Scholar 

  14. S.J. Song, K.S. Kim, K.H. Kim, H.J. Li, J.H. Kim, M.H. Jeong, B.H. Kim, Y.M. Ko, D.L. Cho, J. Mater. Chem. 19, 3248 (2009)

    Article  CAS  Google Scholar 

  15. I.H. Bae, K.S. Lim, D.S. Park, S.Y. Lee, E.J. Jang, M.S. Ji, D.S. Sim, Y.J. Hong, Y. Ahn, J.C. Park, J.G. Cho, J.C. Kang, I.S. Kim, J.W. Nah, M.H. Jeong, J. Ind. Eng. Chem. 21, 1295 (2015)

    Article  CAS  Google Scholar 

  16. J.H. Kim, J.H. Shin, D.H. Shin, M.W. Moon, K. Park, T.H. Kim, K.M. Shin, Y.H. Won, D.K. Han, K.R. Lee, Br. J. Radiol. 84, 210 (2011)

    Article  CAS  Google Scholar 

  17. C.C. Liang, A.Y. Park, J.L. Guan, Nat. Protoc. 2, 329 (2007)

    Article  CAS  Google Scholar 

  18. D.S. Gray, J. Tien, C.S. Chen, J. Biomed. Mater. Res. A 66, 605 (2003)

    Article  Google Scholar 

  19. D.L. Mooradian, P. Trescony, K. Keeney, L.T. Furcht, J. Surg. Res. 53, 74 (1992)

    Article  CAS  Google Scholar 

  20. M. Chen, P.O. Zamora, P. Som, L.A. Pena, S. Osaki, J. Biomater. Sci. Polym. Ed. 14, 917 (2003)

    Article  CAS  Google Scholar 

  21. K. Kono, H. Hiruma, S. Kobayashi, Y. Sato, M. Tanaka, R. Sawada, S. Niimi, PLoS ONE 11, e0158289 (2016)

    Article  Google Scholar 

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Acknowledgements

This study was supported by a Grant from the Korean Health Technology R&D Project (HI13C1527) and the Korea Health Industry Development Institute (KHIDI) (HI17C0471), funded by the Ministry of Health and Welfare, Republic of Korea.

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Authors and Affiliations

  1. The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated By Korea Ministry of Health and Welfare, Gwangju, 61469, Republic of Korea

    Jae Won Shim, In-Ho Bae, Myung Ho Jeong, Dae Sung Park, Jae Un Kim, Mun-Ki Kim, Jung Ha Kim & Doo Sun Sim

  2. Korea Cardiovascular Stent Research Institute, Jangsung, 57248, Republic of Korea

    Jae Won Shim, In-Ho Bae, Myung Ho Jeong, Dae Sung Park, Jae Un Kim, Ju Han Kim & Doo Sun Sim

  3. Department of Cardiology, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea

    Myung Ho Jeong, Ju Han Kim & Doo Sun Sim

  4. National Primate Research Center and Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea

    Kyung-Seob Lim

  5. Molecular Medicine, BK21 Plus, Chonnam National University Graduate School, Gwangju, 61469, Republic of Korea

    Jae Won Shim & Myung Ho Jeong

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  1. Jae Won Shim
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  2. In-Ho Bae
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  3. Myung Ho Jeong
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Correspondence to Myung Ho Jeong.

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Shim, J.W., Bae, IH., Jeong, M.H. et al. Effects of a Titanium Dioxide Thin Film for Improving the Biocompatibility of Diamond-Like Coated Coronary Stents. Met. Mater. Int. 26, 1455–1462 (2020). https://doi.org/10.1007/s12540-019-00424-x

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